BUB1 抗体 (AA 951-1085)
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- 抗原 See all BUB1 抗体
- BUB1 (Budding Uninhibited By Benzimidazoles 1 Homolog (Yeast) (BUB1))
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抗原表位
- AA 951-1085
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This BUB1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 交叉反应
- 人, 小鼠
- 预测反应
- Rat,Dog,Cow,Horse,Rabbit
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human Bub1
- 亚型
- IgG
- Top Product
- Discover our top product BUB1 Primary Antibody
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anti-Budding Uninhibited By Benzimidazoles 1 Homolog (Yeast) (BUB1) (AA 1-1085) antibody
BUB1 适用: 人 WB, IF, PLA 宿主: 兔 Polyclonal unconjugated
anti-Budding Uninhibited By Benzimidazoles 1 Homolog (Yeast) (BUB1) (AA 1-130) antibodyBUB1 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 2F9 unconjugated
anti-Budding Uninhibited By Benzimidazoles 1 Homolog (Yeast) (BUB1) (AA 1-1085) antibodyBUB1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 4C3-4C9 unconjugated
anti-Budding Uninhibited By Benzimidazoles 1 Homolog (Yeast) (BUB1) (AA 1-130) antibodyBUB1 适用: 人 WB, ELISA, IHC, ICC, FACS 宿主: 小鼠 Monoclonal 1A11C7 unconjugated
anti-Budding Uninhibited By Benzimidazoles 1 Homolog (Yeast) (BUB1) antibodyBUB1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Budding Uninhibited By Benzimidazoles 1 Homolog (Yeast) (BUB1) (AA 281-419) antibodyBUB1 适用: 人, 小鼠 WB, IF, ICC, IHC (p), FACS 宿主: 小鼠 Monoclonal 14H5 unconjugated
anti-Budding Uninhibited By Benzimidazoles 1 Homolog (Yeast) (BUB1) (AA 1-1085) antibodyBUB1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Budding Uninhibited By Benzimidazoles 1 Homolog (Yeast) (BUB1) (AA 731-1085) antibodyBUB1 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Budding Uninhibited By Benzimidazoles 1 Homolog (Yeast) (BUB1) antibodyBUB1 适用: 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Budding Uninhibited By Benzimidazoles 1 Homolog (Yeast) (BUB1) (AA 256-577) antibodyBUB1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
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- 抗原
- BUB1 (Budding Uninhibited By Benzimidazoles 1 Homolog (Yeast) (BUB1))
- 别名
- Bub1 (BUB1 产品)
- 别名
- bub1a antibody, bub1l antibody, hbub1 antibody, xbub1 antibody, BUB1A antibody, BUB1L antibody, hBUB1 antibody, AL022991 antibody, Bub1a antibody, C80208 antibody, D2Xrf87 antibody, BUB1 mitotic checkpoint serine/threonine kinase antibody, BUB1, mitotic checkpoint serine/threonine kinase antibody, BUB1 antibody, bub1 antibody, Bub1 antibody
- 背景
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Synonyms: BUB1A, BUB1L, hBUB1, Mitotic checkpoint serine/threonine-protein kinase BUB1, BUB1
Background: Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Plays an important role in defining SGOL1 localization and thereby affects sister chromatid cohesion. Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis.
- 基因ID
- 699
- UniProt
- O43683
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