SUMO2/3 抗体 (C-Term)
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- 抗原 See all SUMO2/3 products
- SUMO2/3 (Small Ubiquitin Related Modifier 2/3 (SUMO2/3))
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抗原表位
- AA 49-81, C-Term
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SUMO2/3 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 预测反应
- X, Zf, B, C, Ha, Pr, Pig
- 纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- 免疫原
- This SUMO2/3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 49-81 amino acids from the C-terminal region of human SUMO2/3.
- 克隆位点
- RB00635
- 亚型
- IgG
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- 应用备注
- IF: 1:100. IF: 1:100. WB: 1:2000. IHC-P: 1:50~100
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
- 有效期
- 6 months
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Adenovirus E4-ORF3 Targets PIAS3 and Together with E1B-55K Remodels SUMO Interactions in the Nucleus and at Virus Genome Replication Domains." in: Journal of virology, Vol. 89, Issue 20, pp. 10260-72, (2015) (PubMed).
: "Signaling via the IL-20 receptor inhibits cutaneous production of IL-1β and IL-17A to promote infection with methicillin-resistant Staphylococcus aureus." in: Nature immunology, Vol. 14, Issue 8, pp. 804-11, (2013) (PubMed).
: "PKC? mediates disturbed flow-induced endothelial apoptosis via p53 SUMOylation." in: The Journal of cell biology, Vol. 193, Issue 5, pp. 867-84, (2011) (PubMed).
: "Lysine deacetylation in ischaemic preconditioning: the role of SIRT1." in: Cardiovascular research, Vol. 89, Issue 3, pp. 643-9, (2011) (PubMed).
: "Keratin hypersumoylation alters filament dynamics and is a marker for human liver disease and keratin mutation." in: The Journal of biological chemistry, Vol. 286, Issue 3, pp. 2273-84, (2011) (PubMed).
: "Neuroprotection resulting from insufficiency of RANBP2 is associated with the modulation of protein and lipid homeostasis of functionally diverse but linked pathways in response to oxidative stress." in: Disease models & mechanisms, Vol. 3, Issue 9-10, pp. 595-604, (2010) (PubMed).
: "Spatial interplay between PIASy and FIP200 in the regulation of signal transduction and transcriptional activity." in: Molecular and cellular biology, Vol. 28, Issue 8, pp. 2771-81, (2008) (PubMed).
: "SUMO modification of the Ets-related transcription factor ERM inhibits its transcriptional activity." in: The Journal of biological chemistry, Vol. 280, Issue 26, pp. 24330-8, (2005) (PubMed).
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Adenovirus E4-ORF3 Targets PIAS3 and Together with E1B-55K Remodels SUMO Interactions in the Nucleus and at Virus Genome Replication Domains." in: Journal of virology, Vol. 89, Issue 20, pp. 10260-72, (2015) (PubMed).
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- 抗原
- SUMO2/3 (Small Ubiquitin Related Modifier 2/3 (SUMO2/3))
- 别名
- SUMO2/3 (SUMO2/3 产品)
- 别名
- SUMO2 antibody, small ubiquitin-like modifier 2 antibody, SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)-like antibody, small ubiquitin-related modifier 2 antibody, SUMO2 antibody, LOC711990 antibody, LOC714892 antibody
- 背景
- SUMO2 and SUMO3 are members of the SUMO (small ubiquitin-like modifier) protein family. This protein family functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. In vertebrates, three members of the SUMO family have been described, SUMO 1 and the functionally distinct homologues SUMO 2 and SUMO 3. SUMO modification sites present in the N terminal regions of SUMO 2 and SUMO 3 are utilized by SAE1/SAE2 (SUMO E1) and Ubc9 (SUMO E2) to form polymeric chains of SUMO 2 and SUMO 3 on protein substrates, a property not shared by SUMO 1.
- 分子量
- 11637
- 基因ID
- 6612
- NCBI登录号
- NP_008867
- UniProt
- P55854
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