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Myc 标记 (AA 423-435) 抗体

ABIN351513 产品详细信息, 供应商: Log in to see
抗原
抗原表位
AA 423-435
56
9
6
4
3
2
2
2
2
2
1
1
适用
标记
212
36
14
10
6
5
3
1
1
宿主
小鼠
160
60
17
16
3
2
1
克隆类型 (克隆位点)
单克隆 ()
标记
非结合性
27
23
14
9
5
4
4
4
4
4
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
应用范围
Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
215
116
77
53
48
34
21
19
18
7
6
5
5
5
5
4
3
3
3
2
1
1
1
1
1
1
1
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品牌 IHC-plus™
免疫原 Synthetic peptide sequence (AEEQKLISEEDLL) corresponding to the C-terminal region of human c-myc. Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla (100%), Orangutan, Monkey, Marmoset, Tamarin (92%), Rat, Sheep, Hamster, Panda, Dog, Horse (85%).

Type of Immunogen: Synthetic peptide
克隆位点 9E10
亚型 IgG1
特异性 The antibody 9E10 may be used to detect the c-Myc tag. The c-myc gene (8q24 on human chromosome) is the cellular homologue of the v-myc gene originally isolated from an avian myelocytomatosis virus. The c-Myc protein is a transcription factor (nuclear localization). c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin-dependent kinase, ERK2 and C-Jun N-terminal Kinase (JNK) in cell proliferation and cell cycle regulation. In normal cells the expression of c-Myc is tightly regulated but in human cancers c-Myc is frequently deregulated. c-Myc is also essential for tumor cell development in vasculogenesis and angiogenesis that distribute blood throughout the cells
预测反应 Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla (100%) Orangutan, Monkey, Marmoset, Tamarin (92%) Rat, Sheep, Hamster, Panda, Dog, Horse (85%).
纯化方法 Protein G purified
物质类 Tag
UniProt P01106
应用备注 Approved: Flo (1 - 5 μg/mL), IHC-P (10 μg/mL), IP (1 - 5 μg/mL), WB (0.5 - 2 μg/mL)

Usage: Immunohistochemistry: This antibody was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody,
限制 仅限研究用
状态 Liquid
浓度 Lot specific
缓冲液 PBS, 15 mM sodium azide, approx, pH 7.4.
储存液 Sodium azide
注意事项 This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项 Avoid repeated freezing and thawing.
储存条件 4 °C,-20 °C
储存方法 +4°C or -20°C, Avoid repeated freezing and thawing.
厂商提供的图像
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Myc 标记 (AA 423-435) 抗体 (ABIN351513) Human Liver (formalin-fixed, paraffin-embedded) stained with c-Myc antibody ABIN35151...