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兔 anti-小鼠 IgG (Fc Region) Antibody

ELISA, WB Polyclonal IgG unconjugated
产品编号 ABIN2837728
发货至: 中国
  • 抗原 See all IgG products
    IgG
    抗原表位
    • 2356
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    • 2
    • 1
    • 1
    • 1
    • 1
    Fc Region
    适用
    • 697
    • 680
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    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    小鼠
    宿主
    • 1727
    • 1486
    • 537
    • 216
    • 118
    • 103
    • 33
    • 31
    • 21
    • 17
    • 15
    • 11
    • 11
    • 1
    克隆类型
    • 3354
    • 193
    • 1
    多克隆
    应用范围
    • 1867
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    • 2
    • 2
    • 2
    • 1
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    • 1
    • 1
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    ELISA, Western Blotting (WB)
    纯化方法
    Caprylic Acid Ammonium Sulfate Precipitation
    免疫原
    Mouse IgG Fc fragment
    亚型
    IgG
  • 应用备注
    Optimal working dilutions should be determined experimentally by the investigator.
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    0.03 % Proclin 300, 50 % Glycerol, 0.01 M PBS, pH 7.4
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    注意事项
    Avoid freeze and thaw cycles.
    储存条件
    -20 °C
    储存方法
    Shipped at 4 °C. Upon delivery aliquot and store at -24 °C or -84 °C.
  • 抗原
    IgG
    Abstract
    IgG 产品
    物质类
    Antibody
    背景
    The fragment crystallizable region (Fc region) is the tail region of an antibody that interacts with cell surface receptors called Fc receptors and some proteins of the complement system. This property allows antibodies to activate the immune system. In IgG, IgA and IgD antibody isotypes, the Fc region is composed of two identical protein fragments, derived from the second and third constant domains of the antibody's two heavy chains, IgM and IgE Fc regions contain three heavy chain constant domains (CH domains 2-4) in each polypeptide chain. The Fc regions of IgGs bear a highly conserved N-glycosylation site. Glycosylation of the Fc fragment is essential for Fc receptor-mediated activity. The N-glycans attached to this site are predominantly core-fucosylated diantennary structures of the complex type. In addition, small amounts of these N-glycans also bear bisecting GlcNAc and α-2,6 linked sialic acid residues. The other part of an antibody, called the Fab region, contains variable sections that define the specific target that the antibody can bind. By contrast, the Fc region of all antibodies in a class are the same for each species, they are constant rather than variable. The Fc region is, therefore, sometimes incorrectly termed the fragment constant region".
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