ABCC8 抗体 (N-Term)
(1 reference)-
- 抗原 See all ABCC8 抗体
- ABCC8 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8))
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抗原表位
- N-Term
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适用
- 人, 大鼠, 小鼠, 犬, Cow, Pig, 兔, 斑马鱼
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This ABCC8 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC)
- 序列
- PLAFCGSENH SAAYRVDQGV LNNGCFVDAL NVVPHVFLLF ITFPILFIGW
- 预测反应
- Cow: 100%, Dog: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 85%
- 产品特性
- This is a rabbit polyclonal antibody against ABCC8. It was validated on Western Blot using a cell lysate as a positive control.
- 纯化方法
- Affinity Purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of human ABCC8
- Top Product
- Discover our top product ABCC8 Primary Antibody
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anti-ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) (AA 679-929) antibody
ABCC8 适用: 人 WB, ELISA, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) (AA 1548-1582) antibodyABCC8 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S289-16 unconjugated
anti-ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) (AA 1548-1582) antibody (HRP)ABCC8 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S289-16 HRP
anti-ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) (AA 1548-1582) antibody (FITC)ABCC8 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S289-16 FITC
anti-ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) (AA 1548-1582) antibody (Alkaline Phosphatase (AP))ABCC8 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S289-16 Alkaline Phosphatase (AP)
anti-ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) (AA 1548-1582) antibody (Biotin)ABCC8 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S289-16 Biotin
anti-ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) (AA 1548-1582) antibody (PE)ABCC8 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S289-16 PE
anti-ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) (AA 1548-1582) antibody (APC)ABCC8 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S289-16 APC
anti-ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) (AA 1548-1582) antibody (PerCP)ABCC8 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S289-16 PerCP
anti-ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) (AA 1548-1582) antibody (Atto 488)ABCC8 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S289-16 Atto 488
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- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
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Antigen size: 1581 AA
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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: "Characterization of acquired paclitaxel resistance of breast cancer cells and involvement of ABC transporters." in: Toxicology and applied pharmacology, Vol. 310, pp. 215-228, (2016) (PubMed).
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: "Characterization of acquired paclitaxel resistance of breast cancer cells and involvement of ABC transporters." in: Toxicology and applied pharmacology, Vol. 310, pp. 215-228, (2016) (PubMed).
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- 抗原
- ABCC8 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8))
- 别名
- ABCC8 (ABCC8 产品)
- 别名
- ABC36 antibody, HHF1 antibody, HI antibody, HRINS antibody, MRP8 antibody, PHHI antibody, SUR antibody, SUR1 antibody, SUR1delta2 antibody, TNDM2 antibody, D930031B21Rik antibody, Sur antibody, Sur1 antibody, ATP binding cassette subfamily C member 8 antibody, ATP-binding cassette, sub-family C (CFTR/MRP), member 8 antibody, ABCC8 antibody, Abcc8 antibody
- 背景
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ABCC8 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). ABCC8 is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion.The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternative splicing of this gene has been observed, however, the transcript variants have not been fully described. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: ABC36, HHF1, HI, HRINS, MRP8, PHHI, SUR, SUR1, TNDM2, SUR1delta2
Protein Interaction Partner: ENSA, KCNJ11, CRYBB1, KCNJ8, RAPGEF4,
Protein Size: 1581 - 分子量
- 177 kDa
- 基因ID
- 6833
- NCBI登录号
- NM_000352, NP_000343
- UniProt
- Q09428
- 途径
- Negative Regulation of Hormone Secretion
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