SIRT6 抗体 (Middle Region)
(2 references)-
- 抗原 See all SIRT6 抗体
- SIRT6 (Sirtuin 6 (SIRT6))
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抗原表位
- Middle Region
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适用
- 人, 大鼠, 犬, Cow
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SIRT6 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunoprecipitation (IP), Chromatin Immunoprecipitation (ChIP)
- 序列
- TRINGSIPAG PKQEPCAQHN GSEPASPKRE RPTSPAPHRP PKRVKAKAVP
- 预测反应
- Cow: 100%, Dog: 100%, Human: 100%, Rat: 83%
- 产品特性
- This is a rabbit polyclonal antibody against SIRT6. It was validated on Western Blot using a cell lysate as a positive control.
- 纯化方法
- Affinity Purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the middle region of human SIRT6
- Top Product
- Discover our top product SIRT6 Primary Antibody
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anti-Sirtuin 6 (SIRT6) (AA 1-334) antibody
SIRT6 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Sirtuin 6 (SIRT6) (AA 141-250) antibodySIRT6 适用: 人 WB, ELISA, IHC, ICC, FACS 宿主: 小鼠 Monoclonal 2G1H1 unconjugated
anti-Sirtuin 6 (SIRT6) antibodySIRT6 适用: 人, 小鼠, 大鼠, 猴 WB, IP, IF 宿主: 小鼠 Monoclonal 6C9-D10-D3 unconjugated
anti-Sirtuin 6 (SIRT6) (N-Term) antibodySIRT6 适用: 人, 小鼠, 大鼠, 犬, Cow, Pig, 豚鼠, 马 WB 宿主: 兔 Polyclonal unconjugated
anti-Sirtuin 6 (SIRT6) (AA 35-274) antibodySIRT6 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Sirtuin 6 (SIRT6) (AA 56-105) antibodySIRT6 适用: 人, 小鼠, 犬, 猴, Pig, Bat, Hamster WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Sirtuin 6 (SIRT6) (AA 141-250) antibodySIRT6 适用: 人 ELISA 宿主: 小鼠 Monoclonal 1D8 unconjugated
anti-Sirtuin 6 (SIRT6) (C-Term) antibodySIRT6 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Sirtuin 6 (SIRT6) (C-Term) antibodySIRT6 适用: 人, 大鼠, 犬, Cow WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Sirtuin 6 (SIRT6) (AA 300-355) antibodySIRT6 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
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Antigen size: 355 AA
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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: "Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors." in: Genes & development, Vol. 27, Issue 20, pp. 2221-6, (2013) (PubMed).
: "An elaborate pathway required for Ras-mediated epigenetic silencing." in: Nature, Vol. 449, Issue 7165, pp. 1073-7, (2007) (PubMed).
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: "Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors." in: Genes & development, Vol. 27, Issue 20, pp. 2221-6, (2013) (PubMed).
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- 抗原
- SIRT6 (Sirtuin 6 (SIRT6))
- 别名
- SIRT6 (SIRT6 产品)
- 别名
- 2810449N18Rik antibody, AI043036 antibody, Sir2l6 antibody, SIR2L6 antibody, zgc:86729 antibody, sirtuin 6 antibody, sirtuin 6 S homeolog antibody, Sirt6 antibody, SIRT6 antibody, sirt6.S antibody, sirt6 antibody
- 背景
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SIRT6 is a NAD-dependent protein deacetylase. SIRT6 has deacetylase activity towards 'Lys-9' and 'Lys-56' of histone H3. SIRT6 modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates 'Lys-9' of histone H3 at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Deacetylation of nucleosomes interferes with RELA binding to target DNA. SIRT6 may be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. SIRT6 is required for genomic stability, normal IGF1 serum levels and normal glucose homeostasis. SIRT6 modulates cellular senescence and apoptosis. SIRT6 regulates the production of TNF protein.This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined, however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.
Alias Symbols: SIR2L6
Protein Interaction Partner: UBC, MDM2, AKT1, STUB1, SKP2, ABCF2, FAF1, VIM, UBE2D1, CHD3, NR0B2, tat, CCNDBP1, RELA, XRCC5, PRKDC, XRCC6, ELF5,
Protein Size: 355 - 分子量
- 39 kDa
- 基因ID
- 51548
- NCBI登录号
- NM_016539, NP_057623
- UniProt
- Q8N6T7
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