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Sirtuin 6 (SIRT6) (Middle Region) 抗体

ABIN2779624 产品详细信息, 供应商: Log in to see
抗原
  • SIR2L6
  • 2810449N18Rik
  • AI043036
  • Sir2l6
  • sirtuin 6
  • sirt6
  • SIRT6
  • Sirt6
抗原表位
Middle Region
75
19
19
18
18
16
12
6
6
6
5
5
5
5
5
3
3
2
2
1
1
1
1
1
1
1
1
适用
牛, 犬, 人, 大鼠
190
71
37
7
4
3
2
2
2
1
1
1
1
宿主

187
22
6
克隆类型
多克隆
标记
非结合性
16
12
10
7
6
6
4
4
4
4
4
3
3
3
1
1
1
1
1
1
1
1
1
1
1
应用范围
Chromatin Immunoprecipitation (ChIP), Immunoprecipitation (IP), Western Blotting (WB)
179
82
57
32
32
32
14
12
9
4
3
3
2
1
Supplier
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免疫原 The immunogen is a synthetic peptide directed towards the middle region of human SIRT6
Blocking Peptide Blocking peptide for this product available: ABIN983773
序列 TRINGSIPAG PKQEPCAQHN GSEPASPKRE RPTSPAPHRP PKRVKAKAVP
预测反应 Cow: 100%, Dog: 100%, Human: 100%, Rat: 83%
产品特性 This is a rabbit polyclonal antibody against SIRT6. It was validated on Western Blot using a cell lysate as a positive control.
纯化方法 Affinity Purified
别名 SIRT6 (SIRT6 Antibody 摘要)
背景 SIRT6 is a NAD-dependent protein deacetylase. SIRT6 has deacetylase activity towards 'Lys-9' and 'Lys-56' of histone H3. SIRT6 modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates 'Lys-9' of histone H3 at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Deacetylation of nucleosomes interferes with RELA binding to target DNA. SIRT6 may be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. SIRT6 is required for genomic stability, normal IGF1 serum levels and normal glucose homeostasis. SIRT6 modulates cellular senescence and apoptosis. SIRT6 regulates the production of TNF protein.This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined, however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.
Alias Symbols: SIR2L6
Protein Interaction Partner: UBC, MDM2, AKT1, STUB1, SKP2, ABCF2, FAF1, VIM, UBE2D1, CHD3, NR0B2, tat, CCNDBP1, RELA, XRCC5, PRKDC, XRCC6, ELF5,
Protein Size: 355
分子量 39 kDa
基因ID 51548
NCBI登录号 NM_016539, NP_057623
UniProt Q8N6T7
研究领域 Cancer
应用备注 Optimal working dilutions should be determined experimentally by the investigator.
说明

Antigen size: 355 AA

限制 仅限研究用
状态 Liquid
浓度 Lot specific
缓冲液 Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
储存液 Sodium azide
注意事项 This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项 Avoid repeated freeze-thaw cycles.
储存条件 -20 °C
储存方法 For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
厂商提供的图像
 image for anti-Sirtuin 6 (SIRT6) (Middle Region) 抗体 (ABIN2779624) anti-Sirtuin 6 (SIRT6) (Middle Region) antibody
有引用在: Wajapeyee, Malonia, Palakurthy, Green: "Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors." in: Genes & development, Vol. 27, Issue 20, pp. 2221-6, 2013 (PubMed).

Gazin, Wajapeyee, Gobeil, Virbasius, Green: "An elaborate pathway required for Ras-mediated epigenetic silencing." in: Nature, Vol. 449, Issue 7165, pp. 1073-7, 2007 (PubMed).