Interleukin 33 抗体 (IL33) (Ser109) (Biotin)

Details for Product anti-IL33 Antibody No. ABIN2661329, 供应商: Log in to see
抗原
  • IL33
  • C9orf26
  • DVS27
  • IL1F11
  • NF-HEV
  • NFEHEV
  • RP11-575C20.2
  • 9230117N10Rik
  • Il-33
  • Il1f11
  • RGD1311155
  • interleukin 33
  • interleukin 33-like
  • interleukin-33-like
  • IL33
  • Il33
  • LOC100356081
  • LOC100518643
Alternatives
anti-小鼠 Interleukin 33 抗体 for Immunofluorescence (fixed cells)
抗原表位
Ser109
68
26
20
15
12
7
6
5
5
4
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
适用
小鼠, 大鼠
290
105
44
8
4
3
2
2
宿主
山羊
188
133
23
23
4
3
2
1
1
克隆类型 (克隆位点)
多克隆 ()
标记
This Interleukin 33 antibody is conjugated to Biotin
35
19
14
14
8
7
5
5
5
4
4
4
3
3
3
3
3
3
3
3
3
3
1
1
1
1
1
1
1
应用范围
Flow Cytometry (FACS)
279
215
89
60
45
24
21
21
16
14
13
11
7
5
5
4
3
3
2
2
2
1
1
Supplier
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免疫原 Ser109-Isoleucin266 (Accession# NM_133775) was expressed in E. coli.
克隆位点 Poly5165
亚型 Ig Fraction, IgG
交叉反应 大鼠
纯化方法 The antibody was purified by antigen affinity chromatography, and conjugated with biotin under optimal conditions. The solution is free of unconjugated biotin.
别名 IL-33 (IL33 Antibody 摘要)
背景 IL-33 belongs to the IL-1 family and is closely related in structure to IL-18 and IL-1b. IL-33, IL-1b, and IL-18 are synthesized as biologically inactive precursor and are cleaved by the enzyme caspase-1 to be secreted as active mature forms. IL-33 stimulates target cells by binding to the IL-1R/TLR superfamily member ST2 and subsequently activates NF-κB and MAPK pathways via identical signalling events to those observed for IL-1b. In addition, IL-33 is a nuclear factor (NF-HEV) abundantly expressed in high endothelial venules from lymphoid organs that associates with chromatin and exhibits transcriptional regulatory properties.
途径 Production of Molecular Mediator of Immune Response
应用备注 Optimal working dilution should be determined by the investigator.
限制 仅限研究用
浓度 0.2 mg/mL
缓冲液 Phosphate-buffered solution, pH 7.2, containing 1 % BSA and 0.09 % sodium azide.
储存液 Sodium azide
注意事项 This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项 Do not freeze.
储存条件 4 °C
储存方法 The antibody solution should be stored undiluted between 2°C and 8°C.
厂商提供的图像
ELISA image for anti-Interleukin 33 抗体 (IL33) (Ser109) (Biotin) (ABIN2661329) anti-Interleukin 33 (IL33) (Ser109) antibody (Biotin)
背景 Gao, Wang, Yang, Zhao, Wen, Li, Lu, Qin, Qi, Xie, Jiang, Wu, Zhang, Chen, Turnquist, Zhu, Lu: "Tumoral expression of IL-33 inhibits tumor growth and modifies the tumor microenvironment through CD8+ T and NK cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 194, Issue 1, pp. 438-45, 2014 (PubMed).

Arend, Palmer, Gabay: "IL-1, IL-18, and IL-33 families of cytokines." in: Immunological reviews, Vol. 223, pp. 20-38, 2008 (PubMed).

Moussion, Ortega, Girard: "The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo: a novel 'alarmin'?" in: PLoS ONE, Vol. 3, Issue 10, pp. e3331, 2008 (PubMed).

Suzukawa, Iikura, Koketsu, Nagase, Tamura, Komiya, Nakae, Matsushima, Ohta, Yamamoto, Yamaguchi: "An IL-1 cytokine member, IL-33, induces human basophil activation via its ST2 receptor." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 181, Issue 9, pp. 5981-9, 2008 (PubMed).

Schmitz, Owyang, Oldham, Song, Murphy, McClanahan, Zurawski, Moshrefi, Qin, Li, Gorman, Bazan, Kastelein: "IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines." in: Immunity, Vol. 23, Issue 5, pp. 479-90, 2005 (PubMed).