CHRNB2 抗体 (Middle Region)
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- 抗原 See all CHRNB2 抗体
- CHRNB2 (Cholinergic Receptor, Nicotinic, beta 2 (Neuronal) (CHRNB2))
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抗原表位
- Middle Region
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适用
- 人, 小鼠, 大鼠, 犬, Cow, Pig, 豚鼠, Saccharomyces cerevisiae
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CHRNB2 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 序列
- KIEVKHFPFD QQNCTMKFRS WTYDRTEIDL VLKSEVASLD DFTPSGEWDI
- 预测反应
- Cow: 93%, Dog: 93%, Guinea Pig: 93%, Human: 100%, Mouse: 93%, Pig: 100%, Rat: 93%, Yeast: 77%
- 产品特性
- This is a rabbit polyclonal antibody against CHRNB2. It was validated on Western Blot using a cell lysate as a positive control.
- 纯化方法
- Protein A purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the middle region of human CHRNB2
- Top Product
- Discover our top product CHRNB2 Primary Antibody
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- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
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Antigen size: 502 AA
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- 抗原
- CHRNB2 (Cholinergic Receptor, Nicotinic, beta 2 (Neuronal) (CHRNB2))
- 别名
- CHRNB2 (CHRNB2 产品)
- 别名
- EFNL3 antibody, nAChRB2 antibody, NACHRB2 antibody, Acrb-2 antibody, Acrb2 antibody, C030030P04Rik antibody, [b]2-nAchR antibody, cholinergic receptor nicotinic beta 2 subunit antibody, cholinergic receptor nicotinic beta 2 subunit S homeolog antibody, cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) antibody, CHRNB2 antibody, chrnb2.S antibody, Chrnb2 antibody
- 背景
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Mutations in nAChRs are found in a rare form of nocturnal frontal lobe epilepsy . Previously, some nAChR mutations have been described that are associated with additional neurological features such as psychiatric disorders or cognitive defects. A new CHRNB2 mutation located in transmembrane region 3 (M3), outside the known ADNFLE mutation cluster. The CHRNB2 mutation I312M, which occurred de novo in twins, markedly increases the receptor's sensitivity to acetylcholine. Phenotypically, the mutation is associated not only with typical ADNFLE, but also with distinct deficits in memory. The cognitive problems are most obvious in tasks requiring the organization and storage of verbal information.
Alias Symbols: EFNL3, nAChRB2
Protein Interaction Partner: CRELD2, CHRNA4, CHRNA2,
Protein Size: 502 - 分子量
- 57 kDa
- 基因ID
- 1141
- NCBI登录号
- NM_000748, NP_000739
- UniProt
- P17787
- 途径
- Sensory Perception of Sound, Feeding Behaviour
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