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GFAP 抗体

GFAP 适用: 人 WB, IF 宿主: 小鼠 Monoclonal MO389 unconjugated
产品编号 ABIN1449150
发货至: 中国
  • 抗原 See all GFAP 抗体
    GFAP (Glial Fibrillary Acidic Protein (GFAP))
    适用
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    宿主
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    小鼠
    克隆类型
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    单克隆
    标记
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    This GFAP antibody is un-conjugated
    应用范围
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    Western Blotting (WB), Immunofluorescence (IF)
    序列
    CQIRETpSLD TKS
    特异性
    This antibody reacts with non phosphorylated GFAP and phosphorylated GFAP.
    交叉反应 (详细)
    Species reactivity (tested):Human
    纯化方法
    Protein A agarose
    免疫原
    KLH conjugated synthetic peptide
    克隆位点
    MO389
    亚型
    IgG1
    Top Product
    Discover our top product GFAP Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 浓度
    1.0 mg/mL
    缓冲液
    PBS containing 50 % glycerol, pH 7.2. No preservative is contained.
    储存液
    Without preservative
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原
    GFAP (Glial Fibrillary Acidic Protein (GFAP))
    别名
    GFAP (GFAP 产品)
    别名
    GFAP antibody, AI836096 antibody, cb345 antibody, etID36982.3 antibody, gfapl antibody, wu:fb34h11 antibody, wu:fk42c12 antibody, xx:af506734 antibody, zgc:110485 antibody, glial fibrillary acidic protein antibody, GFAP antibody, LOC100136168 antibody, gfap antibody, Gfap antibody
    背景
    Intermediate filaments (IFs) constitute major components of the cytoskeleton and the nuclear envelope in most cell types. Unlike other cytoskeletons such as microtubules and actin filaments, the protein components of IFs vary in a cell-, tissue-, and differentiation-dependent manner. Although IFs were thought to be relatively stable compared with actin filaments and microtubules, intensive in vitro investigations revealed that site-specific phosphorylation by several kinases, such as protein kinase A (PKA), protein kinase C (PKC), Ca2+/Calmodulin kinase II (CaMKII), cdc2 kinase, and Rho-kinase alters dynamically their structure and induces filament disruption. Glial fibrillary acidic protein (GFAP) belongs to IF proteins. GFAP is a useful marker of mature astrocytes and mutation in the GFAP gene has recently been associated with Alexander disease. Inagaki et al. reported that GFAP was phosphorylated specifically at Thr-7, Ser-13, and Ser-34 by Rho-kinase and Aurora-B and all of these sites were phosphorylated at the cleavage furrow during cytokinesis.Synonyms: Glial Fibrillary Acidic Protein
    分子量
    approx. 50 kDa
    基因ID
    2670
    NCBI登录号
    NP_001229305
    UniProt
    P14136
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