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beta Amyloid 抗体 (N-Term)

Abeta 适用: 人 EIA, IHC (p), IP 宿主: 小鼠 Monoclonal DE2B4 unconjugated
产品编号 ABIN119716
发货至: 中国
  • 抗原 See all beta Amyloid (Abeta) 抗体
    beta Amyloid (Abeta) (Amyloid beta (Abeta))
    抗原表位
    • 18
    • 17
    • 11
    • 6
    • 6
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-17, N-Term
    适用
    • 69
    • 22
    • 15
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    宿主
    • 41
    • 26
    • 3
    • 2
    小鼠
    克隆类型
    • 37
    • 29
    • 1
    单克隆
    标记
    • 62
    • 5
    • 2
    • 1
    • 1
    • 1
    This beta Amyloid antibody is un-conjugated
    应用范围
    • 53
    • 50
    • 29
    • 17
    • 14
    • 12
    • 8
    • 5
    • 5
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
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    Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)
    纯化方法
    Affinity Chromatography on Protein G.
    免疫原
    Synthetic peptide consisting of residues 1-17 of the Amyloid beta protein.
    克隆位点
    DE2B4
    亚型
    IgG1
    Top Product
    Discover our top product Abeta Primary Antibody
  • 应用备注
    ELISA. Immunoprecipitation. Western Blot. Immunohistochemistry on Paraffin Sections: This product requires protein digestion pre- treatment of paraffin sections using formic acid for 2-3 minutes, the antibody detects extracellular amyloid beta with senile plaques and vessel amyloid in Alzheimers disease brain. Recommended Positive Control: Alzheimers disease brain.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 浓度
    1.0 mg/mL
    缓冲液
    PBS, 0.09 % Sodium Azide
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原
    beta Amyloid (Abeta) (Amyloid beta (Abeta))
    别名
    Amyloid beta (Abeta 产品)
    别名
    AAA antibody, ABETA antibody, ABPP antibody, AD1 antibody, APPI antibody, CTFgamma antibody, CVAP antibody, PN-II antibody, PN2 antibody, aaa antibody, abeta antibody, abpp antibody, ad1 antibody, appi antibody, ctfgamma antibody, cvap antibody, pn2 antibody, Abeta antibody, Abpp antibody, Adap antibody, Ag antibody, Cvap antibody, E030013M08Rik antibody, betaApp antibody, amyloid beta precursor protein antibody, amyloid beta (A4) precursor protein antibody, APP antibody, app antibody, App antibody
    背景
    Amyloid beta precursor protein gene (ABPP) encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Multiple transcript variants encoding several different isoforms have been found for this gene. Isoform APP695 is the predominant form in neuronal tissue, isoform APP751 and isoform APP770 are widely expressed in nonneuronal cells. Isoform APP751 is the most abundant form in T lymphocytes. ABPP is expressed in all fetal tissues examined with the highest levels in brain, kidney, heart and spleen with weak expression observed in liver, ABPP is induced during neuronal differentiation. In the adult brain, highest expression of ABPP gene is found in the frontal lobe of the cortex and in the anterior perisylvian cortex opercular gyri, moderate expression in the cerebellar cortex, the posterior perisylvian cortex opercular gyri and the temporal associated cortex. Weak expression is found in the striate, extra striate and motor cortices. Mutations in ABPP have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy).Synonyms: Amyloid beta peptide
    途径
    Inflammasome
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