Use your antibodies-online credentials, if available.
Human MICA Protein expressed in Human Cells - ABIN2005167
Groh, Steinle, Bauer, Spies: Recognition of stress-induced MHC molecules by intestinal epithelial gammadelta T cells. in Science (New York, N.Y.) 1998
Show all 2 Pubmed References
Study identified the novel role of transcription factors GATA-2 (显示 GATA2 蛋白) and GATA-3 (显示 GATA3 蛋白) in suppressing MICA/B expression in HBV-infected human hepatoma cells.
new MICA allelic variant, MICA*007:07, was identified in an individual of Mongol ethnicity in the Inner Mongolia Autonomous Region, northern China
inhibition of BET proteins can enhance the expression of MICA, a ligand of the NKG2D (显示 KLRK1 蛋白) receptor, in human MM cell lines and primary malignant plasma cells, rendering myeloma cells more efficient to activate NK cell degranulation
results indicate that the polymorphism of rs2256318 in MICA may contribute to the etiology of Preterm birth through interfering with placental development. These findings need to be further validated in larger and multi-ethnic populations.
The results of this study suggested that the MICB (显示 MICB 蛋白)*009N allele might be a risk factor for SLE, whereas the MICB (显示 MICB 蛋白)*014, MICA*010 and MICB (显示 MICB 蛋白)*002 alleles were associated with reduced incidence of SLE in the study population.
New truncated MICA isoforms exhibit a range of functions that may drive unexpected immune mechanisms and provide new tools for immunotherapy
data reveal that MICA and PVR (显示 PVR 蛋白) are directly regulated by human cytomegalovirus immediate early (显示 JUN 蛋白) proteins, and this may be crucial for the onset of an early host antiviral response
This demonstrates for the first time that MICA/B is more broadly expressed in normal tissue and that expression is mainly intracellular with only a small fraction appearing on the cell surface of some epithelia and tumour cells.
selecting a MICA-matched donor significantly influences key clinical outcomes of HCT in which a marked reduction of GVHD is paramount. The tight linkage disequilibrium between MICA and HLA-B renders identifying a MICA-matched donor readily feasible in clinical practice.
MICA-129 matching is relevant in unrelated hematopoietic stem cell transplantation.
Murine inhibitor of carbonic anhydrase was a glycoprotein that associated with carbonic anhydrase in a 1:1 stoichiometry.[ICA]
MICA encodes the higly polymorphic MHC (HLA) class I chain-related gene A. The protein product is expressed on the cell surface, although unlike canonical class I molecules does not seem to associate with beta-2-microglobulin. It is thought that MICA functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Alternative splicing results in multiple transcript variants.
HLA class I antigen
, MHC class I chain-related protein A
, stress inducible class I homolog
, inhibitor of carbonic anhydrase
, F10 alpha chain-like
, class I histocompatibility antigen