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Human MICA Protein expressed in Human Cells - ABIN2005167
Groh, Steinle, Bauer, Spies: Recognition of stress-induced MHC molecules by intestinal epithelial gammadelta T cells. in Science (New York, N.Y.) 1998
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Murine inhibitor of carbonic anhydrase was a glycoprotein that associated with carbonic anhydrase in a 1:1 stoichiometry.[ICA]
The results of this study suggested that the MICB (显示 MICB 蛋白)*009N allele might be a risk factor for SLE, whereas the MICB (显示 MICB 蛋白)*014, MICA*010 and MICB (显示 MICB 蛋白)*002 alleles were associated with reduced incidence of SLE in the study population.
New truncated MICA isoforms exhibit a range of functions that may drive unexpected immune mechanisms and provide new tools for immunotherapy
data reveal that MICA and PVR (显示 PVR 蛋白) are directly regulated by human cytomegalovirus immediate early (显示 JUN 蛋白) proteins, and this may be crucial for the onset of an early host antiviral response
This demonstrates for the first time that MICA/B is more broadly expressed in normal tissue and that expression is mainly intracellular with only a small fraction appearing on the cell surface of some epithelia and tumour cells.
selecting a MICA-matched donor significantly influences key clinical outcomes of HCT in which a marked reduction of GVHD is paramount. The tight linkage disequilibrium between MICA and HLA-B renders identifying a MICA-matched donor readily feasible in clinical practice.
MICA-129 matching is relevant in unrelated hematopoietic stem cell transplantation.
No evidence of an association between MICA*Del and nasopharyngeal carcinoma in the southern Chinese Han population.
These findings identify the major histocompatibility complex-related MICA as an immunogenetic factor that may functionally influence anti-BK polyomavirus immune responses and infection outcomes.
This study provided information on the distribution of MICA polymorphisms and linkage disequilibrium with HLA-B alleles in Brazilian renal-transplant candidates. A total of 19 MICA allele groups were identified. The most frequent allele groups were MICA*008 (21.6%), MICA*002 (17.0%) and MICA*004 (14.8%). The most common haplotypes were MICA*009-B*51 (7.8%), MICA*004-B*44 (6.06%) and MICA*002-B*35 (5.63%).
MICA*A4 protects against ulcerative colitis, whereas MICA*A5.1 is associated with abscess formation and age of onset.
MICA encodes the higly polymorphic MHC (HLA) class I chain-related gene A. The protein product is expressed on the cell surface, although unlike canonical class I molecules does not seem to associate with beta-2-microglobulin. It is thought that MICA functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Alternative splicing results in multiple transcript variants.
HLA class I antigen
, MHC class I chain-related protein A
, stress inducible class I homolog
, inhibitor of carbonic anhydrase
, F10 alpha chain-like
, class I histocompatibility antigen