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CISD2 could be an independent prognostic factor for PC and suggested that the CISD2/Wnt (显示 WNT2 ELISA试剂盒)/beta-catenin (显示 CTNNB1 ELISA试剂盒) pathway contributed to the proliferation of PC and EMT (显示 ITK ELISA试剂盒)
the patient that we describe in this report with the c.215A > G missense CISD2 variant had the classical features of Wolfram syndrome type 1. The c.215A > G (p.Asn72Ser) variant does not induce CISD2 RNA mis (显示 AMH ELISA试剂盒)-splicing or a reduction in CISD2 protein levels. Thus, we report a novel missense homozygous CISD2 mutation in a patient with clinical features that differ from previously reported Wolfram syndrome 2 case reports.
CISD2 exerts anti-apoptotic and anti-inflammatory effects in neural cells; and (2) curcumin can attenuate the downregulation of CISD2 in SCI and LPS (显示 IRF6 ELISA试剂盒)-treated astrocytes.
CISD2 protein may serve as a candidate prognostic marker and a novel therapeutic target for hepatocellular carcinoma (HCC (显示 FAM126A ELISA试剂盒)) and play an important role in promoting proliferation and enhanced progression of HCC (显示 FAM126A ELISA试剂盒).
The findings suggested that CISD2 haplotype-tagging single nucleotide polymorphisms are not associated with Alzheimer's disease risk.
NAF-1 (显示 TNIP1 ELISA试剂盒) is a BCL-2 (显示 BCL2 ELISA试剂盒)-associated co-factor that targets BCL-2 (显示 BCL2 ELISA试剂盒) for antagonism of the autophagy pathway at the endoplasmic reticulum.
NAF-1 (显示 TNIP1 ELISA试剂盒) as a previously unidentified cell target of anti-diabetes thiazolidinedione drugs.
provides the first structural information, to our knowledge, for future targeting of the NAF-1 (显示 TNIP1 ELISA试剂盒)-Bcl-2 (显示 BCL2 ELISA试剂盒) complex in the regulation of apoptosis/autophagy in cancer biology
High CISD2 expression was significantly associated with gastric cancer.
NAF-1 (显示 TNIP1 ELISA试剂盒) is a major player in the metabolic regulation of breast cancer cells.
These studies define a novel role for ABIN1 (显示 TNIP1 ELISA试剂盒) dysfunction and NF-kappaB (显示 NFKB1 ELISA试剂盒) in mediating glomerulonephritis through proinflammatory activation of podocytes.
Suppression of IRAK1 (显示 IRAK1 ELISA试剂盒) or IRAK4 (显示 IRAK4 ELISA试剂盒) Catalytic Activity, but Not Type 1 IFN Signaling, Prevents Lupus Nephritis in Mice Expressing a Ubiquitin Binding-Defective Mutant of ABIN1 (显示 TNIP1 ELISA试剂盒)
NAF-1 (显示 TNIP1 ELISA试剂盒), a BCL-2 (显示 BCL2 ELISA试剂盒)-associated autophagy regulator, is required for homeostatic maintenance of skeletal muscle
Cisd2 deficiency impairs the activation of Wnt (显示 WNT2 ELISA试剂盒)/beta-catenin (显示 CTNNB1 ELISA试剂盒) signaling
These results suggest that the ABIN1 (显示 TNIP1 ELISA试剂盒)-mediated hyperactivation of IKKs and MAPKs might mediate chronic inflammation and CVD development.
Results suggest that that Cisd2 plays an important role in intracellular Ca21 homeostasis, which is required for the differentiation and functioning of adipocytes as well as the regulation of glucose homeostasis in mice.
Miner1 is a redox protein that resides in the ER and that regulates the UPR and mitochondrial function.
studies link ABIN-1 (显示 TNIP1 ELISA试剂盒) with IL-23 (显示 IL23A ELISA试剂盒) and IL-17 (显示 IL17A ELISA试剂盒), and they provide cellular and molecular mechanisms by which ABIN-1 (显示 TNIP1 ELISA试剂盒) regulates susceptibility to psoriasis.
data reveal ABIN1 (显示 TNIP1 ELISA试剂盒) as an essential anti-inflammatory component of TLR-signaling pathways that controls C/EBPbeta (显示 CEBPB ELISA试剂盒) activity
ABIN1 (显示 TNIP1 ELISA试剂盒) requires its ubiquitin binding domain and cooperates with TAX1BP1 (显示 TAX1BP1 ELISA试剂盒) and A20 (显示 TNFAIP3 ELISA试剂盒) to restrict antiviral signaling.
The protein encoded by this gene is a zinc finger protein that localizes to the endoplasmic reticulum. The encoded protein binds an iron/sulfur cluster and may be involved in calcium homeostasis. Defects in this gene are a cause of Wolfram syndrome 2.
CDGSH iron-sulfur domain-containing protein 2A
, CDGSH iron sulfur domain-containing protein 2A
, CDGSH iron sulfur domain-containing protein 2-A
, zinc finger, CDGSH-type domain 2
, CDGSH iron-sulfur domain-containing protein 2
, CDGSH iron sulfur domain-containing protein 2
, CDGSH iron sulfur domain-containing protein 2-B
, CDGSH iron sulfur domain-containing protein 2B
, CDGSH iron-sulfur domain-containing protein 2B
, endoplasmic reticulum intermembrane small protein
, mitoNEET related 1
, mitoNEET-related 1 protein
, nutrient-deprivation autophagy factor-1
, CDGSH iron sulfur domain 2
, nervous system over-expressed protein 70
, nervous system overexpressed protein 70
, H/ACA ribonucleoprotein complex non-core subunit NAF1
, nuclear assembly factor 1 homolog
, A20-binding inhibitor of NF-kappa B activation
, Nef-associated factor 1
, TNFAIP3-interacting protein 1
, virion-associated nuclear shuttling protein