anti-helicase 2, X-linked (ATRX) 抗体

The protein encoded by ATRX contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. 再加上,我们可以发ATRX 蛋白 (4)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
ATRX 546 P46100
ATRX 246284  
ATRX 22589 Q61687

antibodies-online.cn销售最多的anti-ATRX 抗体

Showing 10 out of 104 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
非结合性 FACS, WB RAD54 Antibody (C-term) (ABIN655910) western blot analysis in NCI-H460 cell line lysates (35 µg/lane). This demonstrates the RAD54 antibody detected the RAD54 protein (arrow). 400 μL Log in to see 5至8个工作日
¥2,325.14
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非结合性 IF, ELISA Immunofluorescence analysis of A549 cells, using ATRX Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 24至29个工作日
¥3,026.87
详细
小鼠 非结合性 ELISA, WB Detection limit for recombinant GST tagged ATRX is approximately 0.1 ng/mL as a capture antibody. 0.1 mg Log in to see 11至15个工作日
¥3,179.71
详细
非结合性 ICC, IF, IHC, IHC (p), IP, WB Immunohistochemistry-Paraffin: ATRX Antibody [NBP1-32851] - Human lung carcinoma dilution: 1:500 Western Blot: ATRX Antibody [NBP1-32851] - Whole cell extracts (30 ug) was separated by 5% SDS-PAGE, and the membrane was blotted with ATRX antibody diluted by 1:1000. 0.1 mL Log in to see 25至31个工作日
¥3,655.56
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非结合性 ELISA, WB   100 μg Log in to see 24至29个工作日
¥3,026.87
详细
非结合性 IHC, IHC (p), WB Immunohistochemistry: ATRX Antibody [NBP1-83077] - Immunohistochemical staining of human glioma shows strong nuclear immunoreactivity in tumor cells. Immunohistochemistry: ATRX Antibody [NBP1-83077] - Immunohistochemical staining of human liver shows no positivity 0.1 mL Log in to see 28至35个工作日
¥3,591.24
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非结合性 ICC, IF, IP, IHC (p), WB IHC-P Image Rad54 antibody [C3], C-term detects Rad54 protein at nucleus on human endometrial carcinoma by immunohistochemical analysis. Sample: Paraffin-embedded human endometrial carcinoma. Rad54 antibody [C3], C-term , dilution: 1:500. IHC-P Image Rad54 antibody [C3], C-term detects Rad54 protein at nucleus on human breast carcinoma by immunohistochemical analysis. Sample: Paraffin-embedded human breast carcinoma. Rad54 antibody [C3], C-term , dilution: 1:500. 100 μL Log in to see 23至28个工作日
¥9,012.09
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非结合性 WB Host: Rabbit Target Name: ATRX Sample Type: Jurkat Whole Cell lysates Antibody Dilution: 1.0ug/ml  ATRX is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells 100 μL Log in to see 24至29个工作日
¥3,074.65
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小鼠 非结合性 IHC (p), IHC, ELISA, WB Immunohistochemistry-Paraffin: ATRX Antibody (60.1) [NBP1-02823] - Staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 0.05 mg Log in to see 25至31个工作日
¥3,655.56
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非结合性 WB Western blot of ATRX antibody. Nuclear extract of CCF-STGG1 cells (40 µg per lane) probed with ATRX antibody (pAb) at a dilution of 1:2,500. 100 μL Log in to see 23至29个工作日
¥4,264.21
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通过反应活性、应用领域、克隆类型和共轭标记 ATRX 抗体

特性 应用范围 宿主 克隆类型 标记
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引用最多的anti-ATRX 抗体

  1. Human Polyclonal ATRX Primary Antibody for IHC, IHC (p) - ABIN4282398 : Heaphy, de Wilde, Jiao, Klein, Edil, Shi, Bettegowda, Rodriguez, Eberhart, Hebbar, Offerhaus, McLendon, Rasheed, He, Yan, Bigner, Oba-Shinjo, Marie, Riggins, Kinzler, Vogelstein, Hruban, Maitra et al.: Altered telomeres in tumors with ATRX and DAXX mutations. ... in Science (New York, N.Y.) 2011 (PubMed)
    Show all 16 references for 4282398

  2. Human Monoclonal ATRX Primary Antibody for ELISA, WB - ABIN393693 : Kernohan, Jiang, Tremblay, Bonvissuto, Eubanks, Mann, Bérubé: ATRX partners with cohesin and MeCP2 and contributes to developmental silencing of imprinted genes in the brain. in Developmental cell 2010 (PubMed)
    Show all 5 references for 393693

  3. Human Polyclonal ATRX Primary Antibody for ICC, IF - ABIN442805 : Wille, Maurer, Piatti, Whittle, Rieder, Singewald, Lusser: Impaired Contextual Fear Extinction Learning is Associated with Aberrant Regulation of CHD-Type Chromatin Remodeling Factors. in Frontiers in behavioral neuroscience 2015 (PubMed)
    Show all 2 references for 442805

  4. Human Polyclonal ATRX Primary Antibody for FACS, WB - ABIN655910 : Liu, Shete, Wang, El-Zein, Etzel, Liang, Armstrong, Tsavachidis, Gilbert, Aldape, Xing, Wu, Wei, Bondy: Gamma-radiation sensitivity and polymorphisms in RAD51L1 modulate glioma risk. in Carcinogenesis 2010 (PubMed)

  5. Human Polyclonal ATRX Primary Antibody for ELISA, WB - ABIN1450956 : McKay, Troelstra, van der Spek, Kanaar, Smit, Hagemeijer, Bootsma, Hoeijmakers: Sequence conservation of the rad21 Schizosaccharomyces pombe DNA double-strand break repair gene in human and mouse. in Genomics 1997 (PubMed)

  6. Human Polyclonal ATRX Primary Antibody for IF, ELISA - ABIN1533739 : Villard, Lossi, Cardoso, Proud, Chiaroni, Colleaux, Schwartz, Fontés: Determination of the genomic structure of the XNP/ATRX gene encoding a potential zinc finger helicase. in Genomics 1997 (PubMed)

更多抗ATRX的相互作用对抗体

Human helicase 2, X-linked (ATRX) interaction partners

  1. ATRX loss can be reliable for the pathogenesis of neuroendocrine pancreatic neoplasms.

  2. Mutation in ATRX gene is associated with cancer more frequently in males.

  3. Nek1 (显示 NEK1 抗体) phosphorylates Rad54 and regulates Rad51 (显示 RAD51 抗体) removal to orchestrate homologous recombination and replication fork stability.

  4. Results suggest that cell cycle progression and proliferation of HeLa cells can be tightly controlled by the abundance of RAD51 (显示 RAD51 抗体) and RAD54 proteins, which are essential for the rapid response to postreplicative stress and DNA damage stress.

  5. ATRX interacts with ZNF274 (显示 ZNF274 抗体), TRIM28 (显示 TRIM28 抗体) and SETDB1 (显示 SETDB1 抗体) and binds to the 3' exons of zinc finger genes that present an atypical H3K9me3/H3K36me3 chromatin signature. Depletion of ATRX or ZNF274 (显示 ZNF274 抗体) leads to decreased H3K9me3 levels at zinc finger genes and other atypical chromatin regions.

  6. somatic mutations in the ATRX gene have been observed as recurrent alterations in both osteosarcoma and brain tumors. However, it is unclear if there is any association between osteosarcoma and germline ATRX mutations, specifically in patients with constitutional ATR-X syndrome.

  7. AMab-6 sensitively detects ATRX in Western blot and immunohistochemical analyses, indicating that AMab-6 could become the standard marker to determine the ATRX mutation status of gliomas in immunohistochemical analyses

  8. our study describes a novel missense mutation of the ATRX gene helicase domain, carried by three affected males of the two generations of the same family and segregated with intellectual deficiency, dysmorphism and behaviour disorder without alpha-thalassaemia and with non-skewed X-chromosome inactivation

  9. ATRX mutation is associated with increased mutation rate at the single-nucleotide variant (SNV) level.

  10. ATRX loss may predict better clinical outcome in astrocytoma patients with p53 (显示 TP53 抗体) overexpression as compared to patients with wild-type ATRX

Mouse (Murine) helicase 2, X-linked (ATRX) interaction partners

  1. Our study highlights the importance of the cooperation between Rad54 (显示 RAD54L 抗体) and Mus81 (显示 MUS81 抗体) for mediating DNA DSB repair and restraining chromosome missegregation.

  2. The long noncoding RNA, TERRA (显示 DMRT2 抗体) can bind both in cis (显示 CISH 抗体) to telomeres and in trans to genic targets; a large network of interacting proteins was defined, including epigenetic factors, telomeric proteins, and the RNA helicase, ATRX. TERRA (显示 DMRT2 抗体) and ATRX share hundreds of target genes and are functionally antagonistic at these loci: whereas TERRA (显示 DMRT2 抗体) activates, ATRX represses gene expression.

  3. The changes of ATRX distribution occur and partially correlate with the main stages of zygotic genome activation during mouse early development, butthese changes seem to be determined by other processes of structural and functional rearrangements of blastomere nuclei.

  4. ATRX mutation is associated with increased mutation rate at the single-nucleotide variant (SNV) level.

  5. Daxx (显示 DAXX 抗体) and Atrx safeguard the genome by silencing repetitive elements when DNA methylation (显示 HELLS 抗体) levels are low.

  6. A direct role of Atrx in the establishment and robust maintenance of heterochromatin is demonstrated.

  7. We propose a model whereby ATRX-dependent deposition of H3.3 into heterochromatin is normally required to maintain the memory of silencing at imprinted loci.

  8. ATRX promotes the incorporation of histone H3.3 (显示 H3F3A 抗体) at particular transcribed genes and facilitates transcriptional elongation through G-rich sequences.

  9. Using X chromosome inactivation as a model, study applied an unbiased proteomics approach to isolate Xist and PRC2 regulators and identified ATRX; ATRX functions as a high-affinity RNA-binding protein that directly interacts with RepA/Xist RNA to promote loading of PRC2 in vivo. Without ATRX, PRC2 cannot load onto Xist RNA nor spread in cis (显示 CISH 抗体) along the X chromosome.

  10. These results indicate that while ATRX plays limited roles during early stages of skeletal development, deficiency of the protein in adult tissues does not confer susceptibility to osteoarthritis.

ATRX 抗原简介

蛋白简介

The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.

Gene names and symbols associated with anti-helicase 2, X-linked (ATRX) 抗体

  • alpha thalassemia/mental retardation syndrome X-linked (ATRX) 抗体
  • alpha thalassemia/mental retardation syndrome X-linked (Atrx) 抗体
  • alpha thalassemia/mental retardation syndrome X-linked homolog (human) (Atrx) 抗体
  • RAD54 like (S. cerevisiae) (Rad54l) 抗体
  • 4833408C14Rik 抗体
  • AI447451 抗体
  • ATR2 抗体
  • DXHXS6677E 抗体
  • HP1-BP38 抗体
  • Hp1bp2 抗体
  • Hp1bp38 抗体
  • JMS 抗体
  • MRXHF1 抗体
  • MRXS3 抗体
  • Rad54 抗体
  • RAD54L 抗体
  • SFM1 抗体
  • SHS 抗体
  • XH2 抗体
  • Xnp 抗体
  • ZNF-HX 抗体

Protein level used designations for anti-helicase 2, X-linked (ATRX) 抗体

ATP-dependent helicase ATRX , DNA dependent ATPase and helicase , X-linked helicase II , X-linked nuclear protein , Zinc finger helicase , alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae) , helicase 2, X-linked , transcriptional regulator ATRX , alpha thalassemia/mental retardation syndrome X-linked homolog , helicase II , pABP-2 , XNP , HP1 alpha-interacting protein , alpha thalassemia/mental retardation syndrome (X-linked) , heterochromatin protein 2 , DNA repair and recombination protein RAD54-like , RAD54 homolog , mHR54 , mRAD54

GENE ID SPECIES
100455265 Pongo abelii
546 Homo sapiens
246284 Rattus norvegicus
449625 Pan troglodytes
22589 Mus musculus
19366 Mus musculus
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