alpha-2-Macroglobulin 蛋白 (A2M)

Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. 再加上,我们可以发alpha 2 Macroglobulin 抗体 (297)alpha 2 Macroglobulin 试剂盒 (86)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
A2M 2 P01023
A2M 232345 Q6GQT1
A2M 24153 P06238

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Showing 10 out of 42 products:

产品编号 Origin 资源 标记 图像 规格 供应商 交付 价格 详细
HOST_Baculovirus infected Insect Cells His tag 50 μg Log in to see 14至15个工作日
¥3,859.25
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Insect Cells 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 88至92个工作日
¥278,287.59
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Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 88至92个工作日
¥278,287.59
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HOST_Human 非结合性 5 mg Log in to see 24至29个工作日
¥4,674.14
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HOST_Human 非结合性 1 mg Log in to see 24至29个工作日
¥1,905.78
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大肠杆菌(E. Coli) His tag 100 μg Log in to see 9至12个工作日
¥2,024.10
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大肠杆菌(E. Coli) 大鼠 His tag 100 μg Log in to see 9至12个工作日
¥3,422.48
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大肠杆菌(E. Coli) 小鼠 His tag 100 μg Log in to see 9至12个工作日
¥3,471.04
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大肠杆菌(E. Coli) 野猪 His tag 100 μg Log in to see 9至12个工作日
¥3,733.24
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小麦胚 GST tag 10 μg Log in to see 29至34个工作日
¥2,963.90
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A2M 蛋白 by Origin and Source

Origin 在表达 标记
Human , , , , , ,
, ,
Mouse (Murine) ,

Rat (Rattus) ,

引用最多的alpha 2 Macroglobulin 蛋白

  1. Human alpha 2 Macroglobulin Protein expressed in Human - ABIN491569 : Komissarov, Florova, Azghani, Karandashova, Kurdowska, Idell: Active ?-macroglobulin is a reservoir for urokinase after fibrinolytic therapy in rabbits with tetracycline-induced pleural injury and in human pleural fluids. in American journal of physiology. Lung cellular and molecular physiology 2013 (PubMed)

  2. Human alpha 2 Macroglobulin Protein expressed in Baculovirus infected Insect Cells - ABIN2003651 : Coutinho, Cavalcanti, van Leuven, Araújo-Jorge: Alpha-2-macroglobulin binds to the surface of Trypanosoma cruzi. in Parasitology research 1997 (PubMed)

更多alpha-2-Macroglobulin (A2M)互动伙伴

Human alpha-2-Macroglobulin (A2M) interaction partners

  1. Case Reports: inflammatory myofibroblastic tumors of the lung containing a chimeric A2M-ALK gene categorized as a specific type of inflammatory myofibroblastic tumor that develops exclusively in neonates and infants.

  2. The plasma level of alpha2M was found positively correlated, while HCII (显示 SERPIND1 蛋白) level was negatively correlated with higher vulnerability of carotid plaques. Both proteins were efficient in differentiating stable and vulnerable carotid plaques. These provide potential new targets for the research of carotid plaque vulnerability. Plasma alpha2M and HCII (显示 SERPIND1 蛋白) may be potential biomarkers for evaluation of the vulnerability of carotid ...

  3. Stabilizers during pasteurization improved alpha-2-macroglobulin (alpha2-M) activity by more than 300% points compared with the unstabilized control.

  4. Data show that low that low globulin (GLB (显示 DCXR 蛋白)) levels were significantly associated with favorable survival, and low ALB (显示 ALB 蛋白) levels were associated with a significantly worse survival .

  5. This work demonstrates that alpha2M*/CS-GRP78 (显示 HSPA5 蛋白) acts as an upstream regulator of the PDK1 (显示 PDK1 蛋白)/PLK1 signaling axis to modulate c-MYC (显示 MYC 蛋白) transcription and its target genes, suggesting a therapeutic strategy for targeting c-MYC (显示 MYC 蛋白)-associated malignant progression.

  6. Meta-analysis. Our data indicate that the rs669 (A/G) polymorphisms in A2M gene are associated with increased risk in Parkinson disease.

  7. These data demonstrate that alpha2M* and LRP1 (显示 LRP1 蛋白) modulate the BKCachannel in human myometrium and that BKCaand its immunomodulatory interacting partners regulate Ca(2 (显示 CA2 蛋白)+)dynamics in hMSMCs during pregnancy.

  8. we identify a single serum factor, alpha2-macroglobulin (alpha2M), which is both required and sufficient for rosetting mediated by the parasite protein P. falciparum erythrocyte membrane protein 1 protein HB3VAR06 and some other rosette-mediating PfEMP1 proteins

  9. A2M is expressed in the vasculature and NR4A receptors modulate VSMC MMP2 (显示 MMP2 蛋白)/9 activity by several mechanisms including the up-regulation of A2M.

  10. Data indicate that the expression of salivary alpha2 macroglobulin (alpha2-M) showed a remarkable increase in type 2 diabetes mellitus (T2DM), which may be associated with functional disorders of the salivary gland.

Cow (Bovine) alpha-2-Macroglobulin (A2M) interaction partners

  1. Mutations in the promoter region and the 3'-untranslated region of the A2M gene are involved in the mastitis susceptibility in dairy cows.

  2. We report here for the first time the direct isolation of Spp24 (显示 SPP2 蛋白) covalently bound to alpha2-macroglobulins as a core complex (Spp24 (显示 SPP2 蛋白)-alpha2M) from bovine calf serum.

  3. Exon 29 c.3535A>T in the alpha-2-macroglobulin gene causing aberrant splice variants is associated with mastitis.

  4. These results suggest the possible involvement of cathepsin E (显示 CTSE 蛋白) in disruption of the structural and functional integrity of alpha 2-macroglobulin in the endolysosome system.

  5. Alpha2-macroglobulin is a substrate and an endogenous inhibitor for ADAMTS-4 (显示 ADAMTS4 蛋白) and ADAMTS-5 (显示 ADAMTS5 蛋白)

  6. Amounts of alpha(2)-M receptor in granulosa cells were strongly inversely associated with concentrations of estradiol in dominant and subordinate follicles.

Mouse (Murine) alpha-2-Macroglobulin (A2M) interaction partners

  1. A model is proposed that suggests that unlike proteases, which are irreversibly bound to activated alpha2M, hepcidin (显示 HAMP 蛋白) remains labile and available to down-regulate Fpn1 (显示 SLC40A1 蛋白).

  2. Data show that MAA-A2M adduct formation abrogated the binding of A2M bait region with TGF-beta1, trypsin, and elastase.

  3. MMP9 (显示 MMP9 蛋白) production promoted by the alpha(2)M*/LRP1 (显示 LRP1 蛋白) interaction required the activation of both MAPK (显示 MAPK1 蛋白)-ERK1/2 and NF-kappaB (显示 NFKB1 蛋白) signaling pathways.

  4. Alpha2 macroglobulin requires cyclic amp (显示 TMPRSS5 蛋白) and signal transduction for cell growth

  5. Increased Trypanosoma cruzi invasion and heart fibrosis associated with high transforming growth factor beta levels in mice deficient in alpha(2)-macroglobulin.

  6. the 4622-base pair cDNA encodes a protein of 1473 AA with >70% sequence identity and all typical domains of other A2M-family members in humans and rodents

  7. Data describe the role of the PI3-kinase (显示 PIK3CA 蛋白)/PDK (显示 PDK2 蛋白)/Akt (显示 AKT1 蛋白)/p70s6k (显示 RPS6KB1 蛋白) signaling cascade in alpha 2-macroglobulin-induced cellular proliferation and the role of CREB (显示 CREB1 蛋白) in these events.

  8. review the A2M gene families of mice and humans, the predicted structural relationships between A2M and its pregnancy induced forms and the postulated roles for this gene family in normal pregnancy.

  9. the inhibition of proteases on the surface of microorganisms by an ancestral alpha2M-like thiol ester protein may generate "arrays" of oligomannose glycans to which MBL or other lectins can bind

  10. PDGF (显示 PDGFA 蛋白)-BB and TGF-beta1 (显示 TGFB1 蛋白) binding to intact alpha2M is specific, involving a defined region of the alpha2M subunit

Pig (Porcine) alpha-2-Macroglobulin (A2M) interaction partners

  1. Data suggest that alpha(2)-macroglobulin from serum could significantly compensate for the impaired cumulus expansion of oocytes matured in serum.

蛋白简介alpha 2 Macroglobulin (A2M)

蛋白简介

Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits.

Gene names and symbols associated with alpha-2-Macroglobulin 蛋白 (A2M)

  • alpha-2-macroglobulin (A2M)
  • alpha-2-macroglobulin (LOC733429)
  • alpha-2-macroglobulin (AZL_c00450)
  • alpha-2-macroglobulin (LOC100221148)
  • alpha-2-macroglobulin (LOC100224071)
  • alpha-2-macroglobulin (LOC100349077)
  • ovostatin (OVST)
  • alpha-2-macroglobulin (a2m)
  • alpha-2-macroglobulin (A2m)
  • alpha-2-macroglobulin (LOC100353095)
  • pregnancy-zone protein (PZP)
  • A2M 蛋白
  • A2m1 蛋白
  • A2maa 蛋白
  • A2MAC1 蛋白
  • a2mb 蛋白
  • A2MD 蛋白
  • A2mp 蛋白
  • CPAMD5 蛋白
  • endod 蛋白
  • endodermin 蛋白
  • FWP007 蛋白
  • LOC733429 蛋白
  • LOC100221148 蛋白
  • LOC100224071 蛋白
  • Mam 蛋白
  • S863-7 蛋白

Protein level used designations for alpha-2-Macroglobulin 蛋白 (A2M)

alpha-2-macroglobulin , alpha-2-macroglobulin-like , ovomacroglobulin, ovostatin , alpha 2m , endodermin , Alpha2-macroglobulin , alpha-2-macroglobulin b , C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5 , alpha-2-M , alpha-2-macroglobulin-P , pregnancy zone protein

GENE ID SPECIES
465372 Pan troglodytes
716834 Macaca mulatta
733429 Xenopus laevis
8794592 Azospirillum sp. B510
100221148 Taeniopygia guttata
100224071 Taeniopygia guttata
100349077 Oryctolagus cuniculus
100390764 Callithrix jacchus
396151 Gallus gallus
619586 Xenopus (Silurana) tropicalis
100090399 Ornithorhynchus anatinus
100158443 Xenopus laevis
100469973 Ailuropoda melanoleuca
100595735 Nomascus leucogenys
2 Homo sapiens
100061656 Equus caballus
513856 Bos taurus
232345 Mus musculus
24153 Rattus norvegicus
100353095 Oryctolagus cuniculus
403166 Sus scrofa
477699 Canis lupus familiaris
418251 Gallus gallus
101122940 Ovis aries
101801552 Anas platyrhynchos
100173946 Pongo abelii
100153288 Sus scrofa
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