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Cofactor E is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. 再加上，我们可以发TBCE 蛋白 (6) 和 TBCE 试剂盒 (4)和数多这个蛋白质的别的产品。
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Human Polyclonal TBCE Primary Antibody for WB - ABIN653623
Biernacki, Marina, Zhang, Liu, Bruns, Cai, Neuberg, Canning, Alyea, Soiffer, Brusic, Ritz, Wu: Efficacious immune therapy in chronic myelogenous leukemia (CML) recognizes antigens that are expressed on CML progenitor cells. in Cancer research 2010
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Human Polyclonal TBCE Primary Antibody for EIA, WB - ABIN955104
Padidela, Kelberman, Press, Al-Khawari, Hindmarsh, Dattani: Mutation in the TBCE gene is associated with hypoparathyroidism-retardation-dysmorphism syndrome featuring pituitary hormone deficiencies and hypoplasia of the anterior pituitary and the corpus callosum. in The Journal of clinical endocrinology and metabolism 2009
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Human Polyclonal TBCE Primary Antibody for WB - ABIN520724
Bellouze, Schäfer, Buttigieg, Baillat, Rabouille, Haase: Golgi fragmentation in pmn mice is due to a defective ARF1/TBCE cross-talk that coordinates COPI vesicle formation and tubulin polymerization. in Human molecular genetics 2014
Human Polyclonal TBCE Primary Antibody for ICC, IF - ABIN4358010
Sferra, Baillat, Rizza, Barresi, Flex, Tasca, DAmico, Bellacchio, Ciolfi, Caputo, Cecchetti, Torella, Zanni, Diodato, Piermarini, Niceta, Coppola, Tedeschi, Martinelli, Dionisi-Vici, Nigro et al.: TBCE Mutations Cause Early-Onset Progressive Encephalopathy with Distal Spinal Muscular Atrophy. ... in American journal of human genetics 2016
Although loss of function of TBCE has been documented to impact multiple developmental processes, the present findings provide evidence that hypomorphic TBCE mutations primarily drive neurodegeneration
Sanjad-Sakati syndrome molecular pathology has been shown to be due to mutations in the TBCE gene on chromosome 1q42-q43.
the role of the human TBCE and TBCB (显示 TBCB 抗体) chaperones in alpha-tubulin (显示 TUBA4A 抗体)-beta-tubulin (显示 TUBB 抗体) dissociation, was investigated.
tudies confirmed elevated expression of three target antigens RAB38, TBCE, and DUSP12 in CML.
TBCE has a role in membrane trafficking in the Golgi and late endosomal compartments, tubulin (显示 TUBB 抗体) assembly, and the development of the parathyroid
Tbce is critical for the maintenance of microtubules in mouse motor axons
The tubulin-specific chaperone E (Tbce) mutation described here suggests that alterations in tubulin (显示 TUBB 抗体) assembly lead to retrograde degeneration of motor axons, ultimately resulting in motoneuron cell death.
Reviews recent findings on the molecular mechanisms of the development of the parathyroid glands, with special emphasis on the possible role of tubulin chaperone E (TBCE), implicated in the hypopathyroidism, retardation and dysmorphism (HRD) syndrome.
TBCE, TBCB (显示 TBCB 抗体) and alpha-tubulin (显示 TUBA4A 抗体) form a ternary complex after heterodimer dissociation. These complexes might serve to escort alpha-tubulin (显示 TUBA4A 抗体) towards degradation or recycling, depending on the cell requirements.
Depletion of Op18 (显示 STMN1 抗体) by means of RNA interference increased the susceptibility of tubulin (显示 TUBB 抗体) to TBCE or E-like (显示 TBCEL 抗体) mediated disruption, while overexpressed Op18 (显示 STMN1 抗体) exerted a tubulin (显示 TUBB 抗体)-protective effect.
ARF1 (显示 ARF1 抗体)/TBCE-mediated cross-talk that coordinates COPI formation and tubulin (显示 TUBB 抗体) polymerization at the Golgi.
We conclude from our study that the mutation of the TBCE gene affects the auditory nerve and the cochlear hair cells simultaneously, leading to progressive hearing loss
Cofactor E is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex\; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. Two transcript variants encoding the same protein have been found for this gene.
progressive motor neuropathy
, tubulin-folding cofactor E
, Kenny-Caffey syndrome
, tubulin-specific chaperone E
, beta-tubulin cofactor E