anti-Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) 抗体

TREM2 encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. 再加上,我们可以发TREM2 试剂盒 (28)TREM2 蛋白 (14)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
TREM2 54209 Q9NZC2
TREM2 83433 Q99NH8
TREM2 301227  
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antibodies-online.cn销售最多的anti-TREM2 抗体

Showing 10 out of 204 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 WB 100 μL Log in to see 2至3个工作日
$289.00
详细
小鼠 山羊 非结合性 EIA, WB Sstaining of Mouse Liver lysate using Anti-TREM2 antibody at 0.3 µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 6至8个工作日
$390.50
详细
小鼠 非结合性 EIA, WB 0.1 mL Log in to see 6至8个工作日
$412.50
详细
大鼠 非结合性 CyTOF, FACS Detection of TREM-2 in THP-1 Human Cell Line by Flow Cytometry. THP-1 human acute monocytic leukemia cell line was stained with Rat Anti-Human/Mouse TREM-2 Monoclonal Antibody. Detection of TREM-2 in Human Mature Dendritic Cells by Flow Cytometry. Human mature dendritic cells were stained with Rat Anti-Human/Mouse TREM-2 Monoclonal Antibody. 100 μg Log in to see 8至9个工作日
$294.00
详细
非结合性 FACS, IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human gastritis labeled with Anti-TREM2 Polyclonal Antibody, unconjugated (ABIN749678)  at 1: 200 followed by incubation with conjugated secondary antibody and DAB staining Human colon carcinoma lysate 30ug, probed (ABIN749678) at 1:200 overnight in 4 °C. Followed by conjugation to the secondary antibody at 1:3000 90min in 37 °C. Predicted band size at 25 kDa, and observed band size at 30kDa. 100 μL Log in to see 3至7个工作日
$307.45
详细
山羊 非结合性 CyTOF, FACS, ICC, WB TREM-2 in Human Dendritic Cells. TREM-2 was detected in immersion fixed immature human dendritic cells using Goat Anti-Human TREM-2 Antigen Affinity-purified Polyclonal Antibody. Specific staining was localized to cytoplasm. Detection of Human TREM-2 by Western Blot. Western blot shows lysates of THP-1 human acute monocytic leukemia cell line. PVDF membrane was probed with 0.2 ug/mL of Goat Anti-Human TREM-2 Antigen Affinity-purified Polyclonal Antibody. This experiment was conducted under reducing conditions. 100 μg Log in to see 8至9个工作日
$378.00
详细
小鼠 非结合性 ELISA, SimWes, WB Simple Western: TREM-2 Antibody (2B5) [NBP1-07101] - Simple Western lane view shows a specific band for TREM-2 in 0.5 mg/ml of MCF-7 lysate. This experiment was performed under reducing conditions using the 12-230 kDa separation system. Western Blot: TREM-2 Antibody (2B5) [NBP1-07101] - Cell lysates of HeLa, MCF7, LNCaP and mouse brain (30ug) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human TREM2 (1:500). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. 0.1 mL Log in to see 7至9个工作日
$447.56
详细
小鼠 大鼠 非结合性 EIA, IP   0.1 mg Log in to see 6至8个工作日
$423.50
详细
山羊 非结合性 EIA, IHC (p) 50 μg Log in to see 6至8个工作日
$500.50
详细
山羊 非结合性 IHC, ELISA, WB   100 μg Log in to see 6至7个工作日
$326.89
详细

通过反应活性、应用领域、克隆类型和共轭标记 TREM2 抗体

特性 应用范围 宿主 克隆类型 标记
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引用最多的anti-TREM2 抗体

  1. Human Polyclonal TREM2 Primary Antibody for CyTOF, FACS - ABIN4899382 : Quan, Cooper, Potter, Roberts, Cheng, Jarvis: TREM-2 binds to lipooligosaccharides of Neisseria gonorrhoeae and is expressed on reproductive tract epithelial cells. in Mucosal immunology 2008 (PubMed)
    Show all 3 Pubmed References

  2. Human Monoclonal TREM2 Primary Antibody for ELISA, SimWes - ABIN449602 : Roussos, Katsel, Fam, Tan, Purohit, Haroutunian: The triggering receptor expressed on myeloid cells 2 (TREM2) is associated with enhanced inflammation, neuropathological lesions and increased risk for Alzheimer's dementia. in Alzheimer's & dementia : the journal of the Alzheimer's Association 2015 (PubMed)
    Show all 2 Pubmed References

  3. Human Monoclonal TREM2 Primary Antibody for CyTOF, FACS - ABIN4900550 : Wu, Byers, Jin, Agapov, Alexander-Brett, Patel, Cella, Gilfilan, Colonna, Kober, Brett, Holtzman: TREM-2 promotes macrophage survival and lung disease after respiratory viral infection. in The Journal of experimental medicine 2015 (PubMed)
    Show all 2 Pubmed References

  4. Human Monoclonal TREM2 Primary Antibody for CyTOF, FACS - ABIN4900551 : Kawabori, Kacimi, Kauppinen, Calosing, Kim, Hsieh, Nakamura, Yenari: Triggering receptor expressed on myeloid cells 2 (TREM2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 (PubMed)
    Show all 2 Pubmed References

  5. Mouse (Murine) Monoclonal TREM2 Primary Antibody for IA, FACS - ABIN2191861 : Koga, Inui, Inoue, Kim, Suematsu, Kobayashi, Iwata, Ohnishi, Matozaki, Kodama, Taniguchi, Takayanagi, Takai: Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis. in Nature 2004 (PubMed)

  6. Mouse (Murine) Monoclonal TREM2 Primary Antibody for Func, FACS - ABIN2476938 : Humphrey, Daws, Spusta, Niemi, Torchia, Lanier, Seaman, Nakamura: TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function. in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2006 (PubMed)

  7. Human Polyclonal TREM2 Primary Antibody for FACS, IF (p) - ABIN749678 : Satoh, Kawana, Yamamoto, Ishida, Saito, Arima: A survey of TREM2 antibodies reveals neuronal but not microglial staining in formalin-fixed paraffin-embedded postmortem Alzheimer's brain tissues. in Alzheimer's research & therapy 2014 (PubMed)

更多抗TREM2的相互作用对抗体

Human Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) interaction partners

  1. Mutations in TREM2 gene are known to cause Nasu-Hakola disease.

  2. TREM2 upregulation in the frontal cortex in AD is a late event and may not play a role early in the development of AD pathogenesis and the onset of clinical dementia.

  3. Our results suggest that TREM2 expression is increased in Alzheimer's disease and support previous findings that suggest that p.R47H variant affects TREM2 function by altering binding properties of the receptor rather than expression.

  4. Data show that protein-altering changes are in PLCG2 (显示 PLCG2 抗体), ABI3 (显示 ABI3 抗体), and TREM2 genes highly expressed in microglia and highlight an immune-related protein-protein interaction network in Alzheimer's disease.

  5. Study found that rare variation in TREM2, including two variants within the extracellular Ig-like domain, may be associated with risk for Alzheimer's disease; suggests that impaired overall and cell surface expression of TREM2 may contribute to risk for Alzheimer's disease.

  6. Increased DNA methylation (显示 HELLS 抗体) near TREM2 is seen in the superior temporal gyrus of patients with Alzheimer's disease

  7. Our work identifies the TREM2-APOE (显示 APOE 抗体) pathway as a major regulator of microglial functional phenotype in neurodegenerative diseases and serves as a novel target that could aid in the restoration of homeostatic microglia.

  8. Found increased Alzheimer's disease risk associated with several TREM2 variants, and show that these variants decreased or markedly increased binding to TREM2 ligands. Results suggest that TREM2 signaling helps protect against Alzheimer's disease but can cause harm in excess (显示 RCC1 抗体), supporting the idea that proper TREM2 function is important to counteract disease progression.

  9. SNPs involved in pathways related to virus cellular entry and vesicular trafficking were overrepresented, suggesting that cerebrospinal fluid soluble TREM2 levels could be an informative phenotype for Alzheimer disease

  10. Rare coding variants of TREM2 may play an important role in AD in Han Chinese.

Mouse (Murine) Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) interaction partners

  1. A central role of TREM2 is in the regulation of microglia response to acute neurotoxic insults.

  2. Loss of TREM2 reduces the ability of microglia to engulf amyloid beta-peptide.

  3. TREM2 and TREML2 (显示 TREML2 抗体) play opposite roles in microglia activation.

  4. Our study suggests that Vps35 (显示 vps35 抗体)/retromer is responsible for recycling of Trem2 in the regulation of microglial function such as proinflammatory responses, whereas R47H mutation impairs Trem2 trafficking, which might contribute to Alzheimer disease.

  5. Microglia in Alzheimer's disease (AD) patients carrying TREM2 risk variants and TREM2-deficient mice with AD-like pathology have abundant autophagic vesicles, as do TREM2-deficient macrophages under growth-factor limitation or endoplasmic reticulum (ER) stress. Study concludes that TREM2 enables microglial responses during AD by sustaining cellular energetic and biosynthetic metabolism.

  6. This study demonstrate a critical role of TREM2-mediated Wnt (显示 WNT2 抗体)/beta-catenin (显示 CTNNB1 抗体) pathway in microglial viability and suggest that modulating this pathway therapeutically may help to combat the impaired microglial survival.

  7. Triggering receptor expressed on myeloid cells 2 (TREM2) is an immunoglobulin-like receptor of the TREM family and is expressed on activated macrophages, immature dendritic cells, osteoclasts, and microglia.

  8. TREM2 deficiency may disrupt the formation of a neuroprotective microglia barrier that regulates amyloid compaction and insulation

  9. TREM2 deficiency has opposing effects on Alzheimer's disease-related pathologies at early and late stages of disease progression.

  10. TREM2 protects from Alzheimer's disease by enabling microglia to surround and alter Abeta (显示 APP 抗体) plaque structure, thereby limiting neuritic damage.

TREM2 抗原简介

蛋白简介

This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene names and symbols associated with TREM2

  • triggering receptor expressed on myeloid cells 2 (TREM2) 抗体
  • triggering receptor expressed on myeloid cells 2 (trem2) 抗体
  • trem-like transcript 2 protein (LOC100228399) 抗体
  • triggering receptor expressed on myeloid cells 2 (Trem2) 抗体
  • TREM-2 抗体
  • TREM-A1 抗体
  • TREM-B1 抗体
  • TREM2 抗体
  • Trem2a 抗体
  • Trem2b 抗体
  • Trem2c 抗体

Protein level used designations for TREM2

triggering receptor expressed on myeloid cells 2 , triggering receptor expressed on monocytes 2 , triggering receptor expressed on myeloid cells 2a , triggering receptor expressed on myeloid cells 2b , triggering receptor expressed on myeloid cells 2c

GENE ID SPECIES
419920 Gallus gallus
748470 Pan troglodytes
100126214 Xenopus (Silurana) tropicalis
100228399 Taeniopygia guttata
719740 Macaca mulatta
54209 Homo sapiens
83433 Mus musculus
301227 Rattus norvegicus
608965 Canis lupus familiaris
100737974 Sus scrofa
506467 Bos taurus
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