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Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. 再加上，我们可以发Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 抗体 (76) 和 Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 蛋白 (3)和数多这个蛋白质的别的产品。
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Tank1/Tank2 (显示 TNKS2 ELISA试剂盒) inhibition aggravates kidney injury in the absence of CD2AP (显示 Cd2ap ELISA试剂盒).
The data indicate that the sterile alpha motif domain polymerization is critical for TNKS1 catalytic activity and allows TNKS1 to efficiently access cytoplasmic signaling complexes.
Polymerization is required for Tankyrase to drive beta-catenin (显示 CTNNB1 ELISA试剂盒)-dependent transcription. The polymeric state supports PARP (显示 COL11A2 ELISA试剂盒) activity and allows Tankyrase to effectively access destruction complexes through enabling avidity-dependent AXIN (显示 AXIN1 ELISA试剂盒) binding.
In late S/G2 (显示 STRN3 ELISA试剂盒) phase, the DNA damage-responsive E3 ligase RNF8 (显示 RNF8 ELISA试剂盒) conjugates K63-linked ubiquitin chains to tankyrase 1, while in G1 phase such ubiquitin chains are removed by BRISC, an ABRO1 (显示 FAM175B ELISA试剂盒)/BRCC36 (显示 BRCC3 ELISA试剂盒)-containing deubiquitinase complex.
These structural insights will be invaluable for the functional and biophysical characterization of TNKS1/2, including the role of TNKS oligomerization in protein poly(ADP-ribosyl)ation (PARylation) and PARylation-dependent ubiquitylation.
Results describe the structure of three consecutive TNKS- ankyrin repeat clusters (ARCs). Binding analysis indicates specific ARC (显示 NOL3 ELISA试剂盒) pairs engage bivalent binding partner Axin1 (显示 AXIN1 ELISA试剂盒), and that both rigid and flexible ARC (显示 NOL3 ELISA试剂盒) connections form an adaptable TNKS binding platform.
we show for the first time that Tankyrase 1 inhibitior XAV939 was able to significantly increase the apoptosis induced by 5-FU/DDP, accompanied by the protein expression level alternation of b-catenin, Axin and CSC markers in colon cancer cells.
Data show that poly(ADP-ribose) polymerase (PARP (显示 PARP1 ELISA试剂盒)) enzyme Tankyrase (TNKS) inhibition in colon cancer cells decreases beta-catenin (显示 CTNNB1 ELISA试剂盒) signaling at the level of both Axin (显示 AXIN1 ELISA试剂盒) and APC2.
HCMV modulates the activity of TNKS to induce Axin1 (显示 AXIN1 ELISA试剂盒), resulting in inhibition of the beta-catenin (显示 CTNNB1 ELISA试剂盒) pathway.
Data show that E7449 represents a dual Poly(ADP-ribose) Polymerase 1 (显示 PARP1 ELISA试剂盒)/2 and tankyrase 1/2 inhibitor which has the advantage of targeting Wnt (显示 WNT2 ELISA试剂盒)/beta-catenin (显示 CTNNB1 ELISA试剂盒) signaling addicted tumors.
TNKS1 SNPs (rs11991621 rs10503380, and rs7015700) were associated with non-small cell lung cance risk, whereas rs6601328 and rs12541709 inversely associated with risk
analyses also reveal the structural basis for TNKS substrate recruitment, and shed light on the overall structure of TNKS that should help in developing specific inhibitors of Wnt (显示 WNT2 ELISA试剂盒)/beta-catenin (显示 CTNNB1 ELISA试剂盒) signaling
Data show that Tnks1 and 2 are broadly expressed during mouse development and are essential during kidney and lung development. In the kidney, blockage of tankyrase activity phenocopies the effect of blocking production of all Wnt (显示 WNT2 ELISA试剂盒) ligands.
Collectively, our data suggest that GSK3 contributes to mitotic tankyrase phosphorylation.
insulin (显示 INS ELISA试剂盒)-stimulated insulin-responsive aminopeptidase (显示 LNPEP ELISA试剂盒) translocation remained intact despite substantial GLUT4 (显示 SLC2A4 ELISA试剂盒) knockdown
tankyrase1 is a poly(ADP-ribose) polymerase (显示 PARP1 ELISA试剂盒) with roles in telomere length control by the TRF1 (显示 TERF1 ELISA试剂盒) component of the shelterin complex
Tankyrase 1 is essential but redundant for mouse embryonic development
Tankyrase-deficient mice exhibit increases in energy expenditure, fatty acid oxidation, and insulin (显示 INS ELISA试剂盒)-stimulated glucose utilization.
Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.
, tankyrase 1
, ADP-ribosyltransferase diphtheria toxin-like 5
, TRF1-interacting ankyrin-related ADP-ribose polymerase
, poly [ADP-ribose] polymerase 5A
, tankyrase I
, TRF1-interacting ankyrin-related ADP-ribose polymerase 1