anti-Roundabout, Axon Guidance Receptor, Homolog 3 (Drosophila) (ROBO3) 抗体

ROBO3 is a member of the Roundabout (ROBO) gene family that controls neurite outgrowth, growth cone guidance, and axon fasciculation. 再加上,我们可以发ROBO3 蛋白 (8)ROBO3 试剂盒 (2)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
ROBO3 64221 Q96MS0
ROBO3 315564  
ROBO3 19649  

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Showing 10 out of 88 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
山羊 非结合性 ELISA, WB ABIN190793 (0.5µg/ml) staining of Human Brain (Cerebellum) lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 24至29个工作日
¥9,230.97
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山羊 非结合性 EIA, WB   0.1 mg Log in to see 30至37个工作日
¥3,065.96
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山羊 非结合性 ELISA, WB Western Blot: Robo3 Antibody [NBP1-06071] - Analysis of Robo3 (internal) using this antibody at 0.5 ug/ml in Human Brain (Cerebellum) lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 25至31个工作日
¥3,333.96
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山羊 非结合性 EIA, FACS   0.1 mg Log in to see 29至35个工作日
¥3,884.46
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小鼠 山羊 非结合性 ELISA, WB   100 μg Log in to see 24至29个工作日
¥6,589.10
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山羊 非结合性 ELISA, FACS   100 μg Log in to see 24至29个工作日
¥9,230.97
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山羊 非结合性 ELISA, WB 100 μg Log in to see 29至35个工作日
¥6,088.05
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山羊 非结合性 ELISA, WB 0.1 mg Log in to see 24至29个工作日
¥4,732.45
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小鼠 山羊 非结合性 ELISA   0.1 mg Log in to see 24至29个工作日
¥4,432.21
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山羊 非结合性 FACS, ELISA, WB   0.1 mg Log in to see 24至29个工作日
¥4,732.45
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通过反应活性、应用领域、克隆类型和共轭标记 ROBO3 抗体

特性 应用范围 宿主 克隆类型 标记
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引用最多的anti-ROBO3 抗体

  1. Human Polyclonal ROBO3 Primary Antibody for ELISA, WB - ABIN190793 : Kato, Takeuchi, Sato, Yoneyama, Yamamoto, Matsui, Uematsu, Jung, Kawai, Ishii, Yamaguchi, Otsu, Tsujimura, Koh, Reis e Sousa, Matsuura, Fujita, Akira: Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. in Nature 2006 (PubMed)
    Show all 2 references for 190793

  2. Dog (Canine) Polyclonal ROBO3 Primary Antibody for EIA, FACS - ABIN783922 : Denk, Kaufmann, Stark, Schedel, Lowin, Schubert, Bosserhoff: Slit3 inhibits Robo3-induced invasion of synovial fibroblasts in rheumatoid arthritis. in Arthritis research & therapy 2010 (PubMed)

更多抗ROBO3的相互作用对抗体

Mouse (Murine) Roundabout, Axon Guidance Receptor, Homolog 3 (Drosophila) (ROBO3) interaction partners

  1. This study show that this commissural neuron population includes spinal inhibitory neurons and sensory nociceptors and show that this population depends on Robo/Slit signaling yet crosses the dorsal midline in a Robo3-independent manner.

  2. These findings identify NELL2 (显示 NELL2 抗体) as an axon guidance cue and establish Robo3 as a multifunctional regulator of pathfinding that simultaneously mediates NELL2 (显示 NELL2 抗体) repulsion, inhibits Slit repulsion, and facilitates Netrin attraction to achieve a common guidance purpose.

  3. results suggest that Robo3 evolution was key to sculpting the mammalian brain by converting a receptor for Slit repulsion into one that both silences Slit repulsion and potentiates Netrin attraction

  4. this study demonistrated that Robo3-driven axon midline crossing conditions functional maturation of a large commissural synapse.

  5. Rerouting climbing fibers to an ipsilateral projection reversed complex-spike modulation. Ptf1a (显示 PTF1A 抗体)::cre;Robo3(lox/lox (显示 LOX 抗体)) mice showed severe ataxia (显示 USP14 抗体) indicating the impact of climbing fi ber input on reciprocity of Purkinje cell fi ring during motor coordination.

  6. Posttranscriptional regulation of Robo3 mediated by Musashi-1 (显示 MSI1 抗体) controls midline crossing of precerebellar neurons.

  7. Pax-2 (显示 PAX2 抗体)/RB binding reverses repression of Rig-1 protein.

  8. The Slit receptors Robo2 (显示 ROBO2 抗体) and Robo3/Rig-1 are expressed in the subventricular zone and the rostral migratory stream and Slit1 (显示 SLIT1 抗体) and Slit2 (显示 SLIT2 抗体) are present in the adult septum and are responsible for both the septum and the CP repulsive activity in vitro

  9. Expression of Rig-1 protein by commissural axons is inversely correlated with Slit sensitivity. Removal of Rig-1 results in a total failure of commissural axons to cross.

  10. two functionally antagonistic isoforms of Robo3 with distinct carboxy termini arising from alternative splicing have been found

Human Roundabout, Axon Guidance Receptor, Homolog 3 (Drosophila) (ROBO3) interaction partners

  1. confirmed that ROBO3 increases with clinical grade and miR (显示 MLXIP 抗体)-383 expression is inversely correlated to that of ROBO3

  2. human AKAP79-anchored PKC selectively phosphorylates the Robo3.1 receptor subtype on serine 1330

  3. We report the case of a 10-month-old girl with cross-fixation and inability to abduct who was genetically proven to have horizontal gaze palsy with progressive scoliosis (recessive ROBO3 mutations).

  4. Robo3.1A may prevent the Slit responsiveness by recruiting Robo1 (显示 ROBO1 抗体)/2 into a late endosome- and lysosome-dependent degradation pathway.

  5. The novel ROBO3 mutation in this family may be among the most deleterious

  6. This patient had clinical and neuroimaging characteristics considered pathognomonic of horizontal gaze palsy and progressive scoliosis and yet did not have ROBO3 mutations

  7. Three novel ROBO3 mutations have been identified in consanguineous patients with horizontal gaze palsy and progressive scoliosis.

  8. RIG-I (显示 DDX58 抗体) or melanoma differentiation-associated gene (MDA)5 (显示 IFIH1 抗体) signaling through mitochondrial antiviral signaling protein MAVS (显示 MAVS 抗体) is required for activation of interferon (显示 IFNA 抗体) (IFN)-beta (显示 IFNB1 抗体) production by rotavirus-infected intestinal epithelial cells.

  9. Slit3 (显示 SLIT1 抗体) inhibits Robo3-induced invasion of synovial fibroblasts in rheumatoid arthritis.

  10. mutations in the ROBO3 gene, which shares homology with roundabout (显示 ROBO1 抗体) genes important in axon guidance in developing Drosophila, zebrafish, and mouse.

ROBO3 抗原简介

蛋白简介

This gene is a member of the Roundabout (ROBO) gene family that controls neurite outgrowth, growth cone guidance, and axon fasciculation. ROBO proteins are a subfamily of the immunoglobulin transmembrane receptor superfamily. SLIT proteins 1-3, a family of secreted chemorepellants, are ligands for ROBO proteins and SLIT/ROBO interactions regulate myogenesis, leukocyte migration, kidney morphogenesis, angiogenesis, and vasculogenesis in addition to neurogenesis. This gene, ROBO3, has a putative extracellular domain with five immunoglobulin (Ig)-like loops and three fibronectin (Fn) type III motifs, a transmembrane segment, and a cytoplasmic tail with three conserved signaling motifs: CC0, CC2, and CC3 (CC for conserved cytoplasmic). Unlike other ROBO family members, ROBO3 lacks motif CC1. The ROBO3 gene regulates axonal navigation at the ventral midline of the neural tube. In mouse, loss of Robo3 results in a complete failure of commissural axons to cross the midline throughout the spinal cord and the hindbrain. Mutations ROBO3 result in horizontal gaze palsy with progressive scoliosis (HGPPS)\; an autosomal recessive disorder characterized by congenital absence of horizontal gaze, progressive scoliosis, and failure of the corticospinal and somatosensory axon tracts to cross the midline in the medulla. Alternative transcript variants have been described but have not been experimentally validated.

Gene names and symbols associated with ROBO3

  • roundabout, axon guidance receptor, homolog 3 (Drosophila) (ROBO3) 抗体
  • robo3 (robo3) 抗体
  • roundabout, axon guidance receptor, homolog 3 (Drosophila) (Robo3) 抗体
  • robo3 (TcasGA2_TC006743) 抗体
  • roundabout 3 (robo3) 抗体
  • roundabout homolog 3 (Drosophila) (Robo3) 抗体
  • roundabout, axon guidance receptor, homolog 3 (LOC515936) 抗体
  • CG5423 抗体
  • CG14345 抗体
  • CT17158 抗体
  • DKFZp468G0223 抗体
  • DmelCG5423 抗体
  • dRobo-3 抗体
  • HGPPS 抗体
  • HGPS 抗体
  • Rbig1 抗体
  • Rig-1 抗体
  • Rig1 抗体
  • Robo-3 抗体
  • robo3 抗体
  • Robo3a 抗体
  • Robo3b 抗体

Protein level used designations for ROBO3

retinoblastoma inhibiting gene 1 , roundabout homolog 3 , roundabout-like protein 3 , robo3 , CG5423-PA , robo3-PA , roundabout, axon guidance receptor, homolog 3 , roundabout, axon guidance receptor, homolog 3 (Drosophila) , GLEAN_06743 , roundabout 3 , roundabout homolog 3-like , retinoblastoma-inhibiting gene 1 protein

GENE ID SPECIES
64221 Homo sapiens
33314 Drosophila melanogaster
315564 Rattus norvegicus
466839 Pan troglodytes
489307 Canis lupus familiaris
658818 Tribolium castaneum
716274 Macaca mulatta
100072287 Equus caballus
100172083 Pongo abelii
100322880 Xenopus laevis
100342258 Oryctolagus cuniculus
100403106 Callithrix jacchus
100524637 Sus scrofa
100588193 Nomascus leucogenys
19649 Mus musculus
515936 Bos taurus
100858578 Gallus gallus
100337359 Bos taurus
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