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Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) ELISA试剂盒

PCSK9 encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. 再加上,我们可以发PCSK9 抗体 (152)PCSK9 蛋白 (61)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
PCSK9 255738 Q8NBP7
PCSK9 100102 Q80W65
PCSK9 298296 P59996

antibodies-online.cn销售最多的PCSK9 ELISA试剂盒

Showing 10 out of 66 products:

产品编号 适用 灵敏度 范围 图像 规格 供应商 交付 价格 详细
0.11 ng/mL 0.45-30 ng/mL Typical standard curve 96 Tests Log in to see 13至17个工作日
¥3,994.38
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小鼠 10pg/mL 62.5-4000 pg/mL Mouse PCSK9 PicoKine ELISA Kit standard curve 96 Tests Log in to see 26至32个工作日
¥4,348.49
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1.1 pg/mL 1.1-800 pg/mL Typical standard curve 96 Tests Log in to see 13至17个工作日
¥4,654.26
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大鼠 1.19 ng/mL 3.12-200 ng/mL 96 Tests Log in to see 11至15个工作日
¥3,772.08
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小鸡 4.688 ng/mL 7.813-500 ng/mL   96 Tests Log in to see 10至13个工作日
¥5,717.40
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0.188 ng/mL 0.313-20 ng/mL   96 Tests Log in to see 10至13个工作日
¥5,717.40
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Pig 0.469 ng/mL 0.781-50 ng/mL   96 Tests Log in to see 10至13个工作日
¥5,717.40
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豚鼠 0.094 ng/mL 0.156-10 ng/mL   96 Tests Log in to see 10至13个工作日
¥5,717.40
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小鼠 94-6000 pg/mL   1 kit Log in to see 29至34个工作日
¥6,586.44
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  96 Tests Log in to see 13至17个工作日
¥3,411.38
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引用最多的PCSK9 ELISA试剂盒

  1. Mouse (Murine) PCSK9 ELISA Kit for Sandwich ELISA - ABIN2685159 : Seidah, Benjannet, Wickham, Marcinkiewicz, Jasmin, Stifani, Basak, Prat, Chretien: The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation. in Proceedings of the National Academy of Sciences of the United States of America 2003 (PubMed)
    Show all 3 references for ABIN2685159

  2. Human PCSK9 ELISA Kit for Sandwich ELISA - ABIN820112 : Dogan, Akman, Simsek, Ozdem, Comak, Gokceoglu, Kardelen, Koyun: Assessment of left ventricular function by tissue Doppler echocardiography in pediatric chronic kidney disease. in Renal failure 2015 (PubMed)
    Show all 2 references for ABIN820112

适于 PCSK9 相互作用对的更多 ELISA 试剂盒

Human Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) interaction partners

  1. Low LDL cholesterol levels due to PCSK9 and HMGCR (显示 HMGCR ELISA试剂盒) variants had no causal effect on high risk of Alzheimer's disease, vascular dementia, any dementia, or Parkinson's disease; however, low LDL cholesterol levels may have a causal effect in reducing the risk of Alzheimer's disease.

  2. conditions that cause ER stress regardless of their ability to dysregulate ER Ca(2 (显示 CA2 ELISA试剂盒)+) inhibit PCSK9 secretion, thereby reducing PCSK9-mediated LDLR (显示 LDLR ELISA试剂盒) degradation and promoting LDLR (显示 LDLR ELISA试剂盒)-dependent hepatic cholesterol uptake.

  3. Even though LDLR (显示 LDLR ELISA试剂盒)-R410S and LDLR (显示 LDLR ELISA试剂盒)-WT were similar in levels of cell surface and total receptor and bound equally well to LDL or extracellular PCSK9, the LDLR (显示 LDLR ELISA试剂盒)-R410S was resistant to exogenous PCSK9-mediated degradation in endosomes/lysosomes and showed reduced LDL internalization and degradation relative to LDLR (显示 LDLR ELISA试剂盒)-WT.

  4. Lipid therapy today and tomorrow: anti-PCSK9

  5. First human antibodies were recently approved as the first immunotherapeutic agents for the treatment of severe hypercholesterolemia and in patients with statin intolerance. An additional PCSK9 antibody is presently being studied in phase III clinical trials.[review]

  6. Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to low-density lipoprotein (LDL) receptors leading to their degradation in the liver. Inhibition of PCSK9 leads to an increase in LDL receptors and as a result to a reduction of LDL cholesterol in blood. [review]

  7. Furthermore, the effect of reduction of LDL-C by proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition and by the cholesteryl ester transfer protein (CETP (显示 CETP ELISA试剂盒)) inhibitor anacetrapib on cardiovascular events is currently being investigated in large clinical outcome study programs. [review]

  8. Further information on long-term efficacy, tolerability and cost-effectiveness of PCSK9 inhibition and possibilities of implementation in the healthcare system are awaited from ongoing clinical outcome trials, such as FOURIER, ODYSSEY OUTCOMES, SPIRE 1 (显示 SPIRE1 ELISA试剂盒) and 2 involving more than 70,000 high-risk patients. [review]

  9. The 2 or 4week subcutaneous therapy with the recently approved antibodies alirocumab and evolocumab for inhibition of proprotein convertase subtilisin-kexin type 9 (PCSK9) reduces low-density lipoprotein cholesterol (LDL-C) in addition to statins and ezetimibe by 50-60 %. [review]

  10. study provides the first evidence that GPC3 (显示 GPC3 ELISA试剂盒) can modulate the PCSK9 extracellular activity as a competitive binding partner to the LDLR (显示 LDLR ELISA试剂盒) in HepG2 cells.

Mouse (Murine) Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) interaction partners

  1. conditions that cause ER stress regardless of their ability to dysregulate ER Ca(2 (显示 CA2 ELISA试剂盒)+) inhibit PCSK9 secretion, thereby reducing PCSK9-mediated LDLR (显示 LDLR ELISA试剂盒) degradation and promoting LDLR (显示 LDLR ELISA试剂盒)-dependent hepatic cholesterol uptake.

  2. Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Single Domain Antibodies Are Potent Inhibitors of Low Density Lipoprotein Receptor (显示 LDLR ELISA试剂盒) Degradation.

  3. PCSK9 increases hepatic lipid and lipoprotein production via apoE (显示 APOE ELISA试剂盒)- and LDLR (显示 LDLR ELISA试剂盒)-dependent mechanisms

  4. Podocyte damage triggers marked inductions in plasma PCSK9, and knockout of Pcsk9 ameliorates dyslipidemia in a mouse model of nephrotic syndrome.

  5. polydatin ameliorates lipid and glucose metabolism in type 2 diabetes mellitus by downregulating PCSK9.

  6. binding of PCSK9 to GRP94 (显示 HSP90B1 ELISA试剂盒) protects LDLR (显示 LDLR ELISA试剂盒) from degradation likely by preventing early binding of PCSK9 to LDLR (显示 LDLR ELISA试剂盒)

  7. The absence of PCSK9 results in a sex- and tissue-specific subcellular distribution of the LDLR (显示 LDLR ELISA试剂盒) and VLDLR (显示 VLDLR ELISA试剂盒), which is determined by estradiol levels.

  8. that ox-LDL receptor-1 (显示 OLR1 ELISA试剂盒) and PCSK9 positively influence each other's expression, especially during an inflammatory reaction

  9. Data show that leptin (显示 LEP ELISA试剂盒) treatment suppresses proprotein convertase subtilisin/kexin type 9 (PCSK9) in male, but fails to suppress PCSK9 in female.

  10. The Liver Clock Controls Cholesterol Homeostasis through Trib1 (显示 TRIB1 ELISA试剂盒) Protein-mediated Regulation of PCSK9/Low Density Lipoprotein Receptor (LDLR (显示 LDLR ELISA试剂盒)) Axis.

PCSK9 抗原简介

Antigen Summary

This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. The encoded protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. This protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a third form of autosomal dominant familial hypercholesterolemia (HCHOLA3).

Gene names and symbols associated with PCSK9

  • proprotein convertase subtilisin/kexin type 9 (pcsk9) 抗体
  • proprotein convertase subtilisin/kexin type 9 (PCSK9) 抗体
  • proprotein convertase subtilisin/kexin type 9 (Pcsk9) 抗体
  • proprotein convertase subtilisin/kexin type 9-like (LOC100620501) 抗体
  • AI415265 抗体
  • AI747682 抗体
  • FH3 抗体
  • HCHOLA3 抗体
  • LDLCQ1 抗体
  • NARC-1 抗体
  • Narc1 抗体
  • PC9 抗体

Protein level used designations for PCSK9

proprotein convertase subtilisin/kexin type 9 , convertase subtilisin/kexin type 9 preproprotein , neural apoptosis regulated convertase 1 , subtilisin/kexin-like protease PC9 , NARC-1 , convertase subtilisin , neural apoptosis-regulated convertase 1 , proprotein convertase 9 , proprotein convertase PC9 , proprotein convertase subtilisin/kexin type 9 preproprotein , Proprotein convertase 9 , Subtilisin/kexin-like protease PC9

GENE ID SPECIES
495509 Xenopus laevis
100150316 Danio rerio
100544916 Meleagris gallopavo
255738 Homo sapiens
100102 Mus musculus
298296 Rattus norvegicus
424664 Gallus gallus
100731533 Cavia porcellus
717147 Macaca mulatta
100971792 Pan paniscus
456880 Pan troglodytes
100395116 Callithrix jacchus
100620501 Sus scrofa
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