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anti-Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) 抗体

PCSK9 encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. 再加上,我们可以发PCSK9 试剂盒 (72)PCSK9 蛋白 (61)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
PCSK9 255738 Q8NBP7
PCSK9 100102 Q80W65
PCSK9 298296 P59996

antibodies-online.cn销售最多的anti-PCSK9 抗体

Showing 10 out of 154 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
山羊 非结合性 IHC (p), WB 0.1 mg Log in to see 29至35个工作日
¥3,632.23
详细
山羊 非结合性 EIA, WB HEK293 lysate (10 µg protein in RIPA buffer) overexpressing Human PCSK9 with C-terminal MYC tag probed with AP22408PU-N (1 µg/ml) in Lane A and probed with anti-MYC Tag (1/1000) in lane C. Mock-transfected HEK293 probed with AP22408PU-N (1mg/ml) in Lane B. Primary incubations were for 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 29至35个工作日
¥3,884.46
详细
非结合性 EIA, WB Western blot analysis of PCSK9 Antibody (N-term) in Jurkat cell line lysates (35ug/lane). PCSK9 (arrow) was detected using the purified Pab. 0.4 mL Log in to see 29至35个工作日
¥4,086.26
详细
非结合性 FACS, IHC (p), WB Western blot analysis of PCSK9 antibody (C-term) (ABIN391505) in Hela cell line lysates (35 µg/lane). PCSK9 (arrow) was detected using the purified polyclonal antibody. PCSK9 Antibody (C-term) (ABIN391505) IHC analysis in formalin fixed and paraffin embedded human Colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 5至8个工作日
¥2,325.14
详细
非结合性 FACS, IHC (p), WB Western blot analysis of PCSK9 Antibody (N-term) (ABIN652320) in Jurkat cell line lysates (35 µg/lane). PCSK9 (arrow) was detected using the purified polyclonal antibody. PCSK9 Antibody (N-term) (ABIN652320) IHC analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 5至8个工作日
¥2,325.14
详细
山羊 非结合性 EIA, WB HEK293 lysate (10 µg protein in RIPA buffer) overexpressing Human PCSK9 with C-terminal MYC tag probed with AP22407PU-N (0.5 µg/ml) in Lane A and probed with anti-MYC Tag (1/1000) in lane C. Mock-transfected HEK293 probed with AP22407PU-N(1mg/ml) in Lane B. Primary incubations were for 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 29至35个工作日
¥3,884.46
详细
山羊 非结合性 IHC, ELISA, WB ABIN185371 staining (0.2 µg/mL) of McA cell lysates: untransfected (1), transfected with wild type human pcsk9 (2), transfected with S127R human pcsk9 (3). Data kindly provided by Dr. X-M Sun, Hammersmith Hospital, London. ABIN185371 (0.3 µg/mL) staining of Human Adipose lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 24至29个工作日
¥9,230.97
详细
山羊 非结合性 ChIP, IHC (p), IHC, ELISA, WB Western Blot: PCSK9 Antibody [ABIN268772] - Analysis of PCSK9 in McA cell lysates: untransfected (1), transfected with wild type human PCSK9 (2), transfected with S127R human PCSK9 (3) using ABIN268772 (0.2ug/ml). Data kindly provided by Dr. X-M Sun, Hammersmith Hospital, London. Western Blot: PCSK9 Antibody [ABIN268772] - (0.3ug/ml) staining of Human Adipose lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 25至31个工作日
¥3,655.56
详细
非结合性 IHC (p), WB Anti-PCSK9 antibody, IHC(P) IHC(P): Human Intestinal Cancer Tissue 100 μg Log in to see 26至32个工作日
¥2,560.58
详细
非结合性 IF (p), IHC (p), WB Formalin-fixed and paraffin embedded mouse brain labeled with Rabbit Anti-NARC1 Polyclonal Antibody, Unconjugated (ABIN761831) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 5至7个工作日
¥2,709.56
详细

通过反应活性、应用领域、克隆类型和共轭标记 PCSK9 抗体

特性 应用范围 宿主 克隆类型 标记
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引用最多的anti-PCSK9 抗体

  1. Human Polyclonal PCSK9 Primary Antibody for ChIP, IHC (p) - ABIN268772 : Cohen, Pertsemlidis, Kotowski, Graham, Garcia, Hobbs: Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9. in Nature genetics 2005 (PubMed)
    Show all 10 references for ABIN268772

  2. Human Polyclonal PCSK9 Primary Antibody for IHC (p), WB - ABIN374535 : Lambert, Ancellin, Charlton, Comas, Pilot, Keech, Patel, Sullivan, Cohn, Rye, Barter: Plasma PCSK9 concentrations correlate with LDL and total cholesterol in diabetic patients and are decreased by fenofibrate treatment. in Clinical chemistry 2008 (PubMed)
    Show all 3 references for ABIN374535

  3. Human Polyclonal PCSK9 Primary Antibody for EIA, WB - ABIN453778 : McNutt, Kwon, Chen, Chen, Horton, Lagace: Antagonism of secreted PCSK9 increases low density lipoprotein receptor expression in HepG2 cells. in The Journal of biological chemistry 2009 (PubMed)
    Show all 3 references for ABIN453778

  4. Human Polyclonal PCSK9 Primary Antibody for IHC, ELISA - ABIN185371 : Lalanne, Lambert, Amar, Chétiveaux, Zaïr, Jarnoux, Ouguerram, Friburg, Seidah, Brewer, Krempf, Costet: Wild-type PCSK9 inhibits LDL clearance but does not affect apoB-containing lipoprotein production in mouse and cultured cells. in Journal of lipid research 2005 (PubMed)
    Show all 2 references for ABIN185371

  5. Human Polyclonal PCSK9 Primary Antibody for FACS, IHC (p) - ABIN391505 : Shioji, Mannami, Kokubo, Inamoto, Takagi, Goto, Nonogi, Iwai: Genetic variants in PCSK9 affect the cholesterol level in Japanese. in Journal of human genetics 2004 (PubMed)
    Show all 2 references for ABIN391505

  6. Human Polyclonal PCSK9 Primary Antibody for FACS, IHC (p) - ABIN652320 : Abifadel, Varret, Rabès, Allard, Ouguerram, Devillers, Cruaud, Benjannet, Wickham, Erlich, Derré, Villéger, Farnier, Beucler, Bruckert, Chambaz, Chanu, Lecerf, Luc, Moulin, Weissenbach, Prat, Krempf et al.: Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. ... in Nature genetics 2003 (PubMed)
    Show all 2 references for ABIN652320

  7. Human Polyclonal PCSK9 Primary Antibody for IF (p), IHC (p) - ABIN761831 : Jia, Song, Yang, Ma, Li, Lu, Cao, Zhang, Zhu, Wang, Leng, Cao, Du, Xu: Effects of Tanshinone IIA on the modulation of miR‑33a and the SREBP‑2/Pcsk9 signaling pathway in hyperlipidemic rats. in Molecular medicine reports 2016 (PubMed)

  8. Human Polyclonal PCSK9 Primary Antibody for EIA, WB - ABIN569616 : Kwon, Lagace, McNutt, Horton, Deisenhofer: Molecular basis for LDL receptor recognition by PCSK9. in Proceedings of the National Academy of Sciences of the United States of America 2008 (PubMed)

更多抗PCSK9的相互作用对抗体

Human Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) interaction partners

  1. LC n-3 PUFA intake is associated with a lower risk of nonfatal MI in C-allele carriers of PCSK9 rs11206510 (n = 799) but not in non-C-allele carriers (n = 3188).

  2. the zymogen form of PCSK9 adopts a structure that is distinct from the processed form and is unable to bind a mimetic peptide based on the EGF (显示 EGF 抗体)-A domain of the LDLr (显示 LDLR 抗体).

  3. CRP (显示 CRP 抗体) increased PCSK9 expression by activating p38MAPK (显示 MAPK14 抗体)-HNF1alpha (显示 HNF1A 抗体) pathway, with a certain downstream impairment in LDL metabolism in HepG2 cells.

  4. PCSK9 C-terminal domain (CTD) was found to be essential to induce LDLR (显示 LDLR 抗体) degradation both upon its overexpression in cells or via the extracellular pathway.

  5. Results show that circulating PCSK9 concentration increases with the severity of hepatic fat accumulation in patients at risk of nonalcoholic fatty liver disease.

  6. PCSK9 inhibition with alirocumab on top of statin treatment has the potential to lower LDL cholesterol in some autosomal recessive hypercholesterolemia patients.

  7. CRISPR-Cas9 therapy targeting the human PCSK9 gene in chimeric liver-humanized mice bearing human hepatocytes.

  8. PCSK9 regulates monocyte CCR2 expression and chemotaxis.

  9. PCSK9 is down-regulated in patients with rheumatoid arthritis.

  10. Carriers of the PCSK9 R46L genetic variant have lower very low-density lipoprotein and low-density lipoprotein particle concentrations, lower lipoprotein(a) levels, and lower secretory phospholipase A2 (显示 YWHAZ 抗体) and lipoprotein-associated phospholipase A2 activity, reducing cardiovascular risk.

Mouse (Murine) Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) interaction partners

  1. AdipoR activation by agonists regulated PCSK9 expression and inhibits atherosclerosis in apoE (显示 APOE 抗体)(-/-) mice.

  2. Adeno (显示 ADORA2A 抗体)-associated virus mediated infection with a mouse PCSK9 gain-of-function mutation is a rapid, easy, and efficient approach for inducing hypercholesterolemia and promoting abdominal aortic aneurysms in C57BL/6 mice infused with angiotensin II.

  3. conditions that cause ER stress regardless of their ability to dysregulate ER Ca(2 (显示 CA2 抗体)+) inhibit PCSK9 secretion, thereby reducing PCSK9-mediated LDLR (显示 LDLR 抗体) degradation and promoting LDLR (显示 LDLR 抗体)-dependent hepatic cholesterol uptake.

  4. Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Single Domain Antibodies Are Potent Inhibitors of Low Density Lipoprotein Receptor (显示 LDLR 抗体) Degradation.

  5. PCSK9 increases hepatic lipid and lipoprotein production via apoE (显示 APOE 抗体)- and LDLR (显示 LDLR 抗体)-dependent mechanisms

  6. Podocyte damage triggers marked inductions in plasma PCSK9, and knockout of Pcsk9 ameliorates dyslipidemia in a mouse model of nephrotic syndrome.

  7. polydatin ameliorates lipid and glucose metabolism in type 2 diabetes mellitus by downregulating PCSK9.

  8. binding of PCSK9 to GRP94 (显示 HSP90B1 抗体) protects LDLR (显示 LDLR 抗体) from degradation likely by preventing early binding of PCSK9 to LDLR (显示 LDLR 抗体)

  9. The absence of PCSK9 results in a sex- and tissue-specific subcellular distribution of the LDLR (显示 LDLR 抗体) and VLDLR (显示 VLDLR 抗体), which is determined by estradiol levels.

  10. that ox-LDL receptor-1 (显示 OLR1 抗体) and PCSK9 positively influence each other's expression, especially during an inflammatory reaction

PCSK9 抗原简介

蛋白简介

This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. The encoded protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. This protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a third form of autosomal dominant familial hypercholesterolemia (HCHOLA3).

Gene names and symbols associated with PCSK9

  • proprotein convertase subtilisin/kexin type 9 (pcsk9) 抗体
  • proprotein convertase subtilisin/kexin type 9 (PCSK9) 抗体
  • proprotein convertase subtilisin/kexin type 9 (Pcsk9) 抗体
  • proprotein convertase subtilisin/kexin type 9-like (LOC100620501) 抗体
  • AI415265 抗体
  • AI747682 抗体
  • FH3 抗体
  • HCHOLA3 抗体
  • LDLCQ1 抗体
  • NARC-1 抗体
  • Narc1 抗体
  • PC9 抗体

Protein level used designations for PCSK9

proprotein convertase subtilisin/kexin type 9 , convertase subtilisin/kexin type 9 preproprotein , neural apoptosis regulated convertase 1 , subtilisin/kexin-like protease PC9 , NARC-1 , convertase subtilisin , neural apoptosis-regulated convertase 1 , proprotein convertase 9 , proprotein convertase PC9 , proprotein convertase subtilisin/kexin type 9 preproprotein , Proprotein convertase 9 , Subtilisin/kexin-like protease PC9

GENE ID SPECIES
495509 Xenopus laevis
100150316 Danio rerio
100544916 Meleagris gallopavo
255738 Homo sapiens
100102 Mus musculus
298296 Rattus norvegicus
424664 Gallus gallus
100731533 Cavia porcellus
717147 Macaca mulatta
100971792 Pan paniscus
456880 Pan troglodytes
100395116 Callithrix jacchus
100620501 Sus scrofa
anti-PCSK9 (PCSK9) 抗体 精选生产商
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