anti-Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) 抗体

PCSK9 encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. 再加上,我们可以发PCSK9 试剂盒 (74)PCSK9 蛋白 (64)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
PCSK9 255738 Q8NBP7
PCSK9 100102 Q80W65
PCSK9 298296 P59996

antibodies-online.cn销售最多的anti-PCSK9 抗体

Showing 10 out of 160 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
山羊 非结合性 EIA, WB HEK293 lysate (10 µg protein in RIPA buffer) overexpressing Human PCSK9 with C-terminal MYC tag probed with AP22408PU-N (1 µg/ml) in Lane A and probed with anti-MYC Tag (1/1000) in lane C. Mock-transfected HEK293 probed with AP22408PU-N (1mg/ml) in Lane B. Primary incubations were for 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 29至35个工作日
¥3,884.46
详细
非结合性 EIA, WB Western blot analysis of PCSK9 Antibody (N-term) in Jurkat cell line lysates (35ug/lane). PCSK9 (arrow) was detected using the purified Pab. 0.4 mL Log in to see 29至35个工作日
¥4,086.26
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非结合性 FACS, IHC (p), WB Western blot analysis of PCSK9 antibody (C-term) (ABIN391505) in Hela cell line lysates (35 µg/lane). PCSK9 (arrow) was detected using the purified polyclonal antibody. PCSK9 Antibody (C-term) (ABIN391505) IHC analysis in formalin fixed and paraffin embedded human Colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 5至8个工作日
¥2,325.14
详细
非结合性 FACS, IHC (p), WB Western blot analysis of PCSK9 Antibody (N-term) (ABIN652320) in Jurkat cell line lysates (35 µg/lane). PCSK9 (arrow) was detected using the purified polyclonal antibody. PCSK9 Antibody (N-term) (ABIN652320) IHC analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 5至8个工作日
¥2,325.14
详细
山羊 非结合性 EIA, WB HEK293 lysate (10 µg protein in RIPA buffer) overexpressing Human PCSK9 with C-terminal MYC tag probed with AP22407PU-N (0.5 µg/ml) in Lane A and probed with anti-MYC Tag (1/1000) in lane C. Mock-transfected HEK293 probed with AP22407PU-N(1mg/ml) in Lane B. Primary incubations were for 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 29至35个工作日
¥3,884.46
详细
山羊 非结合性 IHC, ELISA, WB ABIN185371 staining (0.2 µg/mL) of McA cell lysates: untransfected (1), transfected with wild type human pcsk9 (2), transfected with S127R human pcsk9 (3). Data kindly provided by Dr. X-M Sun, Hammersmith Hospital, London. ABIN185371 (0.3 µg/mL) staining of Human Adipose lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 24至29个工作日
¥9,230.97
详细
非结合性 IF (p), IHC (p), WB Formalin-fixed and paraffin embedded mouse brain labeled with Rabbit Anti-NARC1 Polyclonal Antibody, Unconjugated (ABIN761831) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 5至7个工作日
¥2,709.56
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山羊 非结合性 ChIP, IHC (p), IHC, ELISA, WB Western Blot: PCSK9 Antibody [ABIN268772] - Analysis of PCSK9 in McA cell lysates: untransfected (1), transfected with wild type human PCSK9 (2), transfected with S127R human PCSK9 (3) using ABIN268772 (0.2ug/ml). Data kindly provided by Dr. X-M Sun, Hammersmith Hospital, London. Western Blot: PCSK9 Antibody [ABIN268772] - (0.3ug/ml) staining of Human Adipose lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 25至31个工作日
¥3,655.56
详细
非结合性 IHC (p), WB Anti-PCSK9 antibody, IHC(P) IHC(P): Human Intestinal Cancer Tissue 100 μg Log in to see 26至32个工作日
¥2,560.58
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山羊 非结合性 IHC (p), WB   0.1 mg Log in to see 28至34个工作日
¥3,065.96
详细

通过反应活性、应用领域、克隆类型和共轭标记 PCSK9 抗体

特性 应用范围 宿主 克隆类型 标记
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引用最多的anti-PCSK9 抗体

  1. Human Polyclonal PCSK9 Primary Antibody for ChIP, IHC (p) - ABIN268772 : Cohen, Pertsemlidis, Kotowski, Graham, Garcia, Hobbs: Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9. in Nature genetics 2005 (PubMed)
    Show all 10 references for 268772

  2. Human Polyclonal PCSK9 Primary Antibody for EIA, WB - ABIN453778 : McNutt, Kwon, Chen, Chen, Horton, Lagace: Antagonism of secreted PCSK9 increases low density lipoprotein receptor expression in HepG2 cells. in The Journal of biological chemistry 2009 (PubMed)
    Show all 3 references for 453778

  3. Human Polyclonal PCSK9 Primary Antibody for IHC, ELISA - ABIN185371 : Lalanne, Lambert, Amar, Chétiveaux, Zaïr, Jarnoux, Ouguerram, Friburg, Seidah, Brewer, Krempf, Costet: Wild-type PCSK9 inhibits LDL clearance but does not affect apoB-containing lipoprotein production in mouse and cultured cells. in Journal of lipid research 2005 (PubMed)
    Show all 2 references for 185371

  4. Human Polyclonal PCSK9 Primary Antibody for FACS, IHC (p) - ABIN391505 : Shioji, Mannami, Kokubo, Inamoto, Takagi, Goto, Nonogi, Iwai: Genetic variants in PCSK9 affect the cholesterol level in Japanese. in Journal of human genetics 2004 (PubMed)
    Show all 2 references for 391505

  5. Human Polyclonal PCSK9 Primary Antibody for FACS, IHC (p) - ABIN652320 : Abifadel, Varret, Rabès, Allard, Ouguerram, Devillers, Cruaud, Benjannet, Wickham, Erlich, Derré, Villéger, Farnier, Beucler, Bruckert, Chambaz, Chanu, Lecerf, Luc, Moulin, Weissenbach, Prat, Krempf et al.: Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. ... in Nature genetics 2003 (PubMed)
    Show all 2 references for 652320

  6. Human Polyclonal PCSK9 Primary Antibody for IF (p), IHC (p) - ABIN761831 : Jia, Song, Yang, Ma, Li, Lu, Cao, Zhang, Zhu, Wang, Leng, Cao, Du, Xu: Effects of Tanshinone IIA on the modulation of miR‑33a and the SREBP‑2/Pcsk9 signaling pathway in hyperlipidemic rats. in Molecular medicine reports 2016 (PubMed)

  7. Human Polyclonal PCSK9 Primary Antibody for EIA, WB - ABIN569616 : Kwon, Lagace, McNutt, Horton, Deisenhofer: Molecular basis for LDL receptor recognition by PCSK9. in Proceedings of the National Academy of Sciences of the United States of America 2008 (PubMed)

更多抗PCSK9的相互作用对抗体

Human Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) interaction partners

  1. PCSK9 inhibits lipoprotein(a) clearance through the LDLR (显示 LDLR 抗体).

  2. PCSK9 variants reduced fasting LDL-C as well as fasting triglycerides.

  3. Proprotein convertase subtilisin/kexin 9 V4I variant with LDLR (显示 LDLR 抗体) mutations modifies the phenotype of familial hypercholesterolemia

  4. PCSK9 associated with Familial Hypercholesterolemia and Polygenic Hypercholesterolemia in patients with Acute Coronary Syndrome , age /=160 mg/dl.

  5. Results clearly that PCSK9 serum concentrations were associated to liver function and mortality, pointed to the disturbance of steroid regulation in patients with end-stage liver disease and an association of such disturbance with mortality. Further studies are required to acquire a more detailed understanding of the role of PCSK9 in liver-related mortality.

  6. Use Crispr-Cas (显示 CSE1L 抗体) system to introduce nonsense variants into PCSK9 to lower blood cholesterol levels.

  7. PCSK9 decreased in youth participating in an intensive dietary intervention. Change in HOMA-IR was associated with change in PCSK9, independent of weight loss, suggesting an important relationship with insulin (显示 INS 抗体) sensitivity.

  8. these studies support that reductions in Lp(a (显示 APOA 抗体)) with PCSK9 inhibition are partly due to increased LDLR (显示 LDLR 抗体)-mediated uptake. In most situations, Lp(a (显示 APOA 抗体)) appears to compete poorly with LDL for LDLR (显示 LDLR 抗体) binding and internalization, but when LDLR (显示 LDLR 抗体) expression is increased with evolocumab, particularly in the setting of low circulating LDL, Lp(a (显示 APOA 抗体)) is reduced.

  9. Plasma levels of proprotein convertase subtilisin/kexin type 9 (PCSK9), apolipoprotein C-III (apoC3 (显示 APOC3 抗体)) and small dense low density lipoprotein cholesterol (sdLDL-C) showed significant interactions with current dyslipidemias, and were predictive in the screening.

  10. Some loss of function variants in PCSK9 are associated with enhanced LDL cholesterol lowering response to statin therapy.

Mouse (Murine) Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) interaction partners

  1. PCSK9 inhibits lipoprotein(a) clearance through the LDLR (显示 LDLR 抗体).

  2. Use Crispr-Cas (显示 CTNND1 抗体) system to introduce nonsense variants into PCSK9 to lower blood cholesterol levels.

  3. Studied the combination model of a single AAV-PCSK9 injection, high-fat diet, and partial carotid ligation which induces robust atherosclerosis in the flow-disturbed carotid artery within 3 weeks in C57 mice, and results suggest this is a quick and convenient model to study atherosclerosis and mechanisms using any knockout or transgenic mice without having to generate double knockouts.

  4. These observations suggest positive feedback interplay between SMC (显示 DYM 抗体)-derived PCSK9 and mtDNA damage in the proinflammatory milieu involving mtROS. This interaction results in cellular injury, characterized by apoptosis-a hallmark of atherosclerosis.

  5. AdipoR activation by agonists regulated PCSK9 expression and inhibits atherosclerosis in apoE (显示 APOE 抗体)(-/-) mice.

  6. Adeno (显示 ADORA2A 抗体)-associated virus mediated infection with a mouse PCSK9 gain-of-function mutation is a rapid, easy, and efficient approach for inducing hypercholesterolemia and promoting abdominal aortic aneurysms in C57BL/6 mice infused with angiotensin II.

  7. conditions that cause ER stress regardless of their ability to dysregulate ER Ca(2 (显示 CA2 抗体)+) inhibit PCSK9 secretion, thereby reducing PCSK9-mediated LDLR (显示 LDLR 抗体) degradation and promoting LDLR (显示 LDLR 抗体)-dependent hepatic cholesterol uptake.

  8. Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Single Domain Antibodies Are Potent Inhibitors of Low Density Lipoprotein Receptor (显示 LDLR 抗体) Degradation.

  9. PCSK9 increases hepatic lipid and lipoprotein production via apoE (显示 APOE 抗体)- and LDLR (显示 LDLR 抗体)-dependent mechanisms

  10. Podocyte damage triggers marked inductions in plasma PCSK9, and knockout of Pcsk9 ameliorates dyslipidemia in a mouse model of nephrotic syndrome.

PCSK9 抗原简介

蛋白简介

This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. The encoded protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. This protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a third form of autosomal dominant familial hypercholesterolemia (HCHOLA3).

Gene names and symbols associated with PCSK9

  • proprotein convertase subtilisin/kexin type 9 (pcsk9) 抗体
  • proprotein convertase subtilisin/kexin type 9 (PCSK9) 抗体
  • proprotein convertase subtilisin/kexin type 9 (Pcsk9) 抗体
  • proprotein convertase subtilisin/kexin type 9-like (LOC100620501) 抗体
  • AI415265 抗体
  • AI747682 抗体
  • FH3 抗体
  • HCHOLA3 抗体
  • LDLCQ1 抗体
  • NARC-1 抗体
  • Narc1 抗体
  • PC9 抗体

Protein level used designations for PCSK9

proprotein convertase subtilisin/kexin type 9 , convertase subtilisin/kexin type 9 preproprotein , neural apoptosis regulated convertase 1 , subtilisin/kexin-like protease PC9 , NARC-1 , convertase subtilisin , neural apoptosis-regulated convertase 1 , proprotein convertase 9 , proprotein convertase PC9 , proprotein convertase subtilisin/kexin type 9 preproprotein , Proprotein convertase 9 , Subtilisin/kexin-like protease PC9

GENE ID SPECIES
495509 Xenopus laevis
100150316 Danio rerio
100544916 Meleagris gallopavo
255738 Homo sapiens
100102 Mus musculus
298296 Rattus norvegicus
424664 Gallus gallus
100731533 Cavia porcellus
717147 Macaca mulatta
100971792 Pan paniscus
456880 Pan troglodytes
100395116 Callithrix jacchus
100620501 Sus scrofa
anti-PCSK9 (PCSK9) 抗体 精选生产商
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