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PCSK9 encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. 再加上，我们可以发PCSK9 试剂盒 (65) 和 PCSK9 蛋白 (61)和数多这个蛋白质的别的产品。
Showing 10 out of 152 products:
Human Polyclonal PCSK9 Primary Antibody for ChIP, IHC (p) - ABIN268772
Cohen, Pertsemlidis, Kotowski, Graham, Garcia, Hobbs: Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9. in Nature genetics 2005
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Human Polyclonal PCSK9 Primary Antibody for WB - ABIN493159
Yue, Averna, Lin, Schonfeld: The c.43_44insCTG variation in PCSK9 is associated with low plasma LDL-cholesterol in a Caucasian population. in Human mutation 2006
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Human Polyclonal PCSK9 Primary Antibody for IHC (p), WB - ABIN374535
Lambert, Ancellin, Charlton, Comas, Pilot, Keech, Patel, Sullivan, Cohn, Rye, Barter: Plasma PCSK9 concentrations correlate with LDL and total cholesterol in diabetic patients and are decreased by fenofibrate treatment. in Clinical chemistry 2008
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Human Polyclonal PCSK9 Primary Antibody for EIA, WB - ABIN453778
McNutt, Kwon, Chen, Chen, Horton, Lagace: Antagonism of secreted PCSK9 increases low density lipoprotein receptor expression in HepG2 cells. in The Journal of biological chemistry 2009
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Human Polyclonal PCSK9 Primary Antibody for IHC, ELISA - ABIN185371
Lalanne, Lambert, Amar, Chétiveaux, Zaïr, Jarnoux, Ouguerram, Friburg, Seidah, Brewer, Krempf, Costet: Wild-type PCSK9 inhibits LDL clearance but does not affect apoB-containing lipoprotein production in mouse and cultured cells. in Journal of lipid research 2005
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Human Polyclonal PCSK9 Primary Antibody for FACS, IHC (p) - ABIN652320
Shioji, Mannami, Kokubo, Inamoto, Takagi, Goto, Nonogi, Iwai: Genetic variants in PCSK9 affect the cholesterol level in Japanese. in Journal of human genetics 2004
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Human Polyclonal PCSK9 Primary Antibody for FACS, IHC (p) - ABIN391505
Abifadel, Varret, Rabès, Allard, Ouguerram, Devillers, Cruaud, Benjannet, Wickham, Erlich, Derré, Villéger, Farnier, Beucler, Bruckert, Chambaz, Chanu, Lecerf, Luc, Moulin, Weissenbach, Prat, Krempf et al.: Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. ... in Nature genetics 2003
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Human Polyclonal PCSK9 Primary Antibody for IF (p), IHC (p) - ABIN761831
Jia, Song, Yang, Ma, Li, Lu, Cao, Zhang, Zhu, Wang, Leng, Cao, Du, Xu: Effects of Tanshinone IIA on the modulation of miR‑33a and the SREBP‑2/Pcsk9 signaling pathway in hyperlipidemic rats. in Molecular medicine reports 2016
Human Polyclonal PCSK9 Primary Antibody for EIA, WB - ABIN569616
Kwon, Lagace, McNutt, Horton, Deisenhofer: Molecular basis for LDL receptor recognition by PCSK9. in Proceedings of the National Academy of Sciences of the United States of America 2008
Data from this cross sectional study in a small sample of patients showed that plasma PCSK9 was correlated with the presence of calcific aortic valve disease but not its severity.
Serum PCSK9 levels were found lower in intrauterine growth restriction only in male neonates born before 34 weeks of gestation.
PCSK9 levels are linearly associated with the fraction and amount of necrotic core tissue in coronary atherosclerosis, independently of serum LDL cholesterol levels and statin use
Both PCSK9 levels and CETP (显示 CETP 抗体) activity were higher in patients with an increasing number of metabolic syndrome components
Circulating PCSK9 levels were correlated with an atherogenic lipid profile and with insulin (显示 INS 抗体) resistance parameters; The rs11591147 genetic variant of PCSK9 resulted in lower levels of circulating PCSK9 and LDL cholesterol
PCSK9 increases hepatic lipid and lipoprotein production via apoE (显示 APOE 抗体)- and LDLR (显示 LDLR 抗体)-dependent mechanisms
Possible inter-locus interactions among the DOCK7 (显示 DOCK7 抗体), PCSK9 and GALNT2 (显示 GALNT2 抗体) SNPs were also noted.
In this study, variants in PCSK9 had approximately the same effect as variants in HMGCR (显示 HMGCR 抗体) on the risk of cardiovascular events and diabetes per unit decrease in the LDL cholesterol level. The effects of these variants were independent and additive.
During sepsis, PCSK9 levels are highly correlated with the development of subsequent multiple organ failure. Inhibition of PCSK9 activity is an attractive target for treating the spectrum of sepsis and septic shock.
Report increased intestinal cholesterol absorption and elevated serum cholesterol in families with primary hypercholesterolemia without mutations in PCSK9.
Podocyte damage triggers marked inductions in plasma PCSK9, and knockout of Pcsk9 ameliorates dyslipidemia in a mouse model of nephrotic syndrome.
polydatin ameliorates lipid and glucose metabolism in type 2 diabetes mellitus by downregulating PCSK9.
binding of PCSK9 to GRP94 (显示 HSP90B1 抗体) protects LDLR (显示 LDLR 抗体) from degradation likely by preventing early binding of PCSK9 to LDLR (显示 LDLR 抗体)
The absence of PCSK9 results in a sex- and tissue-specific subcellular distribution of the LDLR (显示 LDLR 抗体) and VLDLR (显示 VLDLR 抗体), which is determined by estradiol levels.
that ox-LDL receptor-1 (显示 OLR1 抗体) and PCSK9 positively influence each other's expression, especially during an inflammatory reaction
Data show that leptin (显示 LEP 抗体) treatment suppresses proprotein convertase subtilisin/kexin type 9 (PCSK9) in male, but fails to suppress PCSK9 in female.
The Liver Clock Controls Cholesterol Homeostasis through Trib1 (显示 TRIB1 抗体) Protein-mediated Regulation of PCSK9/Low Density Lipoprotein Receptor (LDLR (显示 LDLR 抗体)) Axis.
Hepatic LDLR (显示 LDLR 抗体) levels are up-regulated in SEC24A (显示 SEC24A 抗体)-deficient cells as a consequence of specific dependence of PCSK9, a negative regulator of LDLR (显示 LDLR 抗体), on SEC24A (显示 SEC24A 抗体) for efficient exit from the ensoplasmic reticulum.
PCSK9(-/-) mice display normal sodium balance and blood pressure regulation despite an increase of cleaved alphaENaC (显示 SCNN1A 抗体) under basal condition
This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. The encoded protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. This protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a third form of autosomal dominant familial hypercholesterolemia (HCHOLA3).
proprotein convertase subtilisin/kexin type 9
, convertase subtilisin/kexin type 9 preproprotein
, neural apoptosis regulated convertase 1
, subtilisin/kexin-like protease PC9
, convertase subtilisin
, neural apoptosis-regulated convertase 1
, proprotein convertase 9
, proprotein convertase PC9
, proprotein convertase subtilisin/kexin type 9 preproprotein
, Proprotein convertase 9
, Subtilisin/kexin-like protease PC9