Ornithine Aminotransferase 蛋白 (OAT)

OAT encodes the mitochondrial enzyme ornithine aminotransferase, which is a key enzyme in the pathway that converts arginine and ornithine into the major excitatory and inhibitory neurotransmitters glutamate and GABA. 再加上,我们可以发OAT 试剂盒 (9)OAT 抗体 (7)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
小鼠 OAT OAT 18242 P29758
OAT 64313 P04182
OAT 4942 P04181

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OAT 蛋白 by Origin and Source

Origin 在表达 标记
Rat (Rattus)

Human

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Mouse (Murine) Ornithine Aminotransferase (OAT) interaction partners

  1. The data highlight the importance of OAT in ornithine metabolism, especially in the liver, and suggest a post-transcriptional regulation of OAT by LPS (显示 TLR4 蛋白) in the liver.

  2. in female and castrated male mice devoided of testosterone, OAT gene is highly expressed and L-ornithine is converted into L-glutamate (显示 GRIN1 蛋白).

  3. In H4Flox liver, glutamine synthetase (GS (显示 GLUL 蛋白)), ornithine aminotransferase (OAT) and thyroid hormone-receptor (显示 THRA 蛋白) beta1 (TRbeta1 (显示 THRB 蛋白)) were exclusively expressed in pericentral hepatocytes.

  4. Sexual dimorphism of Oat expression in the kidney was observed.

Human Ornithine Aminotransferase (OAT) interaction partners

  1. Sequencing of the gene for ornithine aminotransferase reveals a homozygous mutation in our patient (base exchange c.498C>A in Exon 4).

  2. Neurogenesis is inhibited by X-OAT during Xenopus embryonic development, but it is essential for Xenopus embryonic development. The Arg 180 and Leu 402 are crucial for these effects of the OAT molecule in development.

  3. Our report describes the first case of gyrate atrophy in the Korean population diagnosed by OAT gene analysis and treated with vitamin B6 dietary supplementation.

  4. We identified a novel frameshift mutation (p.K169DfsX10) in the OAT gene. While an early arginine-restricted dietary treatment suppressed the fundus changes

  5. Data suggest that other factors besides the specific ornithine aminotransferase (OAT) genotype modulate atrophy of choroid and retina (GA) phenotype in patients.

  6. OAT was a highly homologous and stable protein located in the mitochondria.

  7. Molecular analysis revealed a new deletion c.532_536delTGGGG (p.Trp178X) and a known mutation c.897C>G (p.Tyr299X) in the OAT gene.

  8. Fundus autofluorescence imaging can reveal the extent of neurosensory dysfunction in gyrate atrophy patients.

  9. analysis of ornithine aminotransferase substrate specificity

蛋白简介OAT

蛋白简介

This gene encodes the mitochondrial enzyme ornithine aminotransferase, which is a key enzyme in the pathway that converts arginine and ornithine into the major excitatory and inhibitory neurotransmitters glutamate and GABA. Mutations that result in a deficiency of this enzyme cause the autosomal recessive eye disease Gyrate Atrophy. Alternatively spliced transcript variants encoding different isoforms have been described. Related pseudogenes have been defined on the X chromosome.

Gene names and symbols associated with Ornithine Aminotransferase 蛋白 (OAT)

  • Ornithine aminotransferase precursor (Oat)
  • ornithine aminotransferase (oat)
  • ornithine aminotransferase (OAT)
  • ornithine aminotransferase (Lbys_2951)
  • ornithine aminotransferase (Riean_0998)
  • ornithine aminotransferase (Ftrac_2019)
  • ornithine aminotransferase (Celal_2605)
  • ornithine aminotransferase (Deipr_1149)
  • ornithine aminotransferase (Celly_0230)
  • ornithine aminotransferase (Weevi_2065)
  • ornithine aminotransferase (Fluta_4071)
  • ornithine aminotransferase (Halhy_2848)
  • ornithine aminotransferase (Theth_0565)
  • ornithine aminotransferase (Oat)
  • 151832_at 蛋白
  • AI194874 蛋白
  • CG8782 蛋白
  • Dmel\\CG8782 蛋白
  • GACR 蛋白
  • HOGA 蛋白
  • OATASE 蛋白
  • OKT 蛋白
  • rOAT 蛋白

Protein level used designations for Ornithine Aminotransferase 蛋白 (OAT)

CG8782-PA , Oat-PA , ornithine aminotransferase , ornithine aminotransferase precursor , ornithine aminotransferase (gyrate atrophy) , ornithine aminotransferase, mitochondrial , ornithine--oxo-acid aminotransferase , gyrate atrophy , ornithine delta-aminotransferase , ornithine-oxo-acid aminotransferase

GENE ID SPECIES
40145 Drosophila melanogaster
379754 Xenopus laevis
450803 Pan troglodytes
477858 Canis lupus familiaris
9956831 Leadbetterella byssophila DSM 17132
10001754 Riemerella anatipestifer ATCC 11845 = DSM 15868
10012165 Marivirga tractuosa DSM 4126
10145026 Cellulophaga algicola DSM 14237
10256630 Deinococcus proteolyticus MRP
10262214 Cellulophaga lytica DSM 7489
10283330 Weeksella virosa DSM 16922
10399445 Fluviicola taffensis DSM 16823
10587022 Haliscomenobacter hydrossis DSM 1100
10885318 Thermotoga thermarum DSM 5069
100337582 Xenopus laevis
18242 Mus musculus
64313 Rattus norvegicus
4942 Homo sapiens
505323 Bos taurus
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