Neutrophil Cytosolic Factor 4, 40kDa 蛋白 (NCF4)

The protein encoded by NCF4 is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. 再加上,我们可以发Neutrophil Cytosolic Factor 4, 40kDa 抗体 (122)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
NCF4 17972 P97369
大鼠 NCF4 NCF4 500904  
NCF4 4689 Q15080

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大肠杆菌(E. Coli) His tag 100 μg Log in to see 33至41个工作日
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大肠杆菌(E. Coli) His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 48至57个工作日
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大肠杆菌(E. Coli) 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 48至57个工作日
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HOST_HEK-293 Cells Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 28至34个工作日
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大肠杆菌(E. Coli) His tag Validation with Western Blot 50 μg Log in to see 28至34个工作日
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NCF4 蛋白 by Origin and Source

Origin 在表达 标记
Mouse (Murine)
,
Human , ,
, , ,

引用最多的Neutrophil Cytosolic Factor 4, 40kDa 蛋白

  1. Human NCF4 Protein expressed in Escherichia coli (E. coli) - ABIN1098430 : Eglinton, Roberts, Pearson, Barclay, Merriman, Frizelle, Gearry: Clinical and genetic risk factors for perianal Crohn's disease in a population-based cohort. in The American journal of gastroenterology 2012 (PubMed)

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Mouse (Murine) Neutrophil Cytosolic Factor 4, 40kDa (NCF4) interaction partners

  1. These studies demonstrate a critical role of phosphatidylinositol 3-phosphate-p40(phox) binding for optimal activation of the NADPH oxidase (显示 NOX1 蛋白) in macrophages.

  2. Our data reveal a specific role for NCF4-mediated intracellular ROS (显示 ROS1 蛋白) production in regulating autoimmunity and chronic inflammation.

  3. p40phox deficiency leads to upregulation of chemokine receptor 1 (显示 CMKLR1 蛋白) and downregulation of fucosyltransferases and sialyltransferases involved in glycan modifications during experimental intestinal inflammation.

  4. cooperation of p40(phox) with p47(phox) for Nox2 (显示 CYBB 蛋白)-based NADPH oxidase (显示 NOX1 蛋白) activation during Fcgamma receptor (FcgammaR)-mediated phagocytosis

  5. The defect in Reactive Oxygen Species production and killing of s aureus by p40(phox-/-) neutrophils defines p40(phox) as an essential component in bacterial killing.

  6. p40 (显示 LANCL1 蛋白)(phoxR58A/R58A) embryos do not develop normally but p40 (显示 LANCL1 蛋白)(phoxR58A/-) mice are viable and neutrophils from these animals exhibit significantly reduced oxidase responses compared to those from their p40(phox+/-) siblings.

  7. Class III PI3K Vps34 (显示 PIK3C3 蛋白) is responsible for the synthesis of PtdIns(3)P on phagosomes containing either S aureus or E coli. PtdIns(3)P binding to p40(phox) is important for CD18 (显示 ITGB2 蛋白)-dependent activation oxidase activation in response to S aureus and E coli

  8. p40(phox) is prephosphorylated in resting endothelial cells and can compensate p47(phox) in keeping basal ROS (显示 ROS1 蛋白) production.

Human Neutrophil Cytosolic Factor 4, 40kDa (NCF4) interaction partners

  1. Phosphoinositol 3-phosphate regulates reactive oxygen species production by maintaining p40phox and p67phox (显示 NCF2 蛋白) at the phagosomal membrane.

  2. NCF4 polymorphism was associated with Crohn's disease, but not ulcerative colitis in Caucasian--{REVIEW}

  3. NCF4 may induce ex- pression of NADPH oxidase (显示 NOX1 蛋白) enzymes, such as p67phox (显示 NCF2 蛋白), p47phox, p22phox (显示 CYBA 蛋白) and NOX2 (显示 CYBB 蛋白), which lead to increased ROS (显示 ROS1 蛋白) levels.

  4. Germline variation in NCF4, an innate immunity gene, is associated with an increased risk of colorectal cancer.

  5. The contribution of the functionally relevant NADPH polymorphisms rs1883112 and rs4673 to anthracycline-related heart lesions provides a plausible explanation for their modulation of cardiotoxicity.

  6. Constitutive and inducible intracellular production of reactive oxygen species (ROS (显示 ROS1 蛋白)) is higher in B cells expressing functional p40phox, supporting a direct role for p40phox in regulating B cell intracellular ROS (显示 ROS1 蛋白) generation.

  7. Genome-wide association studies-reported associations between the NELL1, NCF4, and FAM92B genes and susceptibility to Crohn's disease could not be replicated in Canadian children and young adults.

  8. Younger age at diagnosis, complicated disease behavior, and ileal disease location are risk factors for perianal CD. First report of an association of the NCF4 gene with perianal disease.

  9. cooperation of p40(phox) with p47(phox) for Nox2 (显示 CYBB 蛋白)-based NADPH oxidase (显示 NOX1 蛋白) activation during Fcgamma receptor (FcgammaR)-mediated phagocytosis

  10. Results demonstrate that PBEF (显示 NAMPT 蛋白) can prime for PMN (显示 TBCE 蛋白) respiratory burst activity by promoting p40 (显示 IL9 蛋白) and p47 (显示 ING1 蛋白) translocation to the membrane.

Cow (Bovine) Neutrophil Cytosolic Factor 4, 40kDa (NCF4) interaction partners

  1. Study proposes that NCF4 splice variants generated by functional SNP are important risk factors for mastitis susceptibility in dairy cows.

蛋白简介Neutrophil Cytosolic Factor 4, 40kDa (NCF4)

蛋白简介

The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Gene names and symbols associated with NCF4

  • p40phox protein (p40phox)
  • neutrophil cytosolic factor 4 (LOC100136241)
  • neutrophil cytosolic factor 4 (Ncf4)
  • neutrophil cytosolic factor 4, 40kDa (NCF4)
  • AI451400 蛋白
  • NCF 蛋白
  • P40PHOX 蛋白
  • SH3PXD4 蛋白

Protein level used designations for NCF4

p40phox protein , neutrophil cytosolic factor 4 , NADPH oxidase cytosolic protein p40phox , NCF-4 , neutrophil NADPH oxidase factor 4 , neutrophil cytosol factor 4 , p40-phox , SH3 and PX domain-containing protein 4

GENE ID SPECIES
445891 Takifugu rubripes
100136241 Oncorhynchus mykiss
17972 Mus musculus
500904 Rattus norvegicus
4689 Homo sapiens
481277 Canis lupus familiaris
507859 Bos taurus
100009359 Oryctolagus cuniculus
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