anti-Mycn (MYCN) 抗体

MYCN is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. 再加上,我们可以发MYCN 蛋白 (7)MYCN 试剂盒 (6)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
MYCN 4613 P04198
MYCN 18109 P03966
MYCN 298894 Q63379
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antibodies-online.cn销售最多的anti-MYCN 抗体

Showing 10 out of 98 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
非结合性 IF (p), IHC (p), WB 100 μL Log in to see 3至7个工作日
$307.45
详细
Cow 非结合性 WB 100 μL Log in to see 2至3个工作日
$229.00
详细
非结合性 WB 100 μg Log in to see 4至6个工作日
$240.00
详细
非结合性 WB Western blot analysis of MYCN antibody (C-term) (ABIN391590) in CEM cell line lysates (35 µg/lane). MYCN (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10至11个工作日
$324.50
详细
非结合性 EIA, WB Western blot analysis of MYCN antibody (C-term) in CEM cell line lysates (35ug/lane). MYCN (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6至8个工作日
$390.50
详细
小鼠 非结合性 ChIP, CyTOF, FACS, GS, ICC, IF, IP, WB Immunocytochemistry/ Immunofluorescence: n-Myc Antibody (NMYC-1) [ABIN152254] - The n-Myc (NMYC-1) antibody was tested in NTERA2 cells at a 1:50 dilution against Dylight 488 (Green). Actin and nuclei were counterstained against Phalloidin 568 (Red) and DAPI (Blue), respectively. Western Blot: n-Myc Antibody (NMYC-1) [ABIN152254] - Western blot analysis of n-Myc expression in human heart tissue. 0.1 mL Log in to see 7至9个工作日
$408.19
详细
Bat 非结合性 WB 100 μg Log in to see 7至9个工作日
$493.17
详细
小鼠 非结合性 WB Western Blot analysis of MYCN expression in transfected 293T cell line by MYCN monoclonal antibody (M01), clone 3H4. Lane 1: MYCN transfected lysate(49.6 KDa). Lane 2: Non-transfected lysate. Western blot analysis of MYCN over-expressed 293 cell line, cotransfected with MYCN Validated Chimera RNAi used as specificity and loading control. 0.1 mg Log in to see 8至11个工作日
$450.00
详细
小鼠 非结合性 ELISA, WB 100 μg Log in to see 7至9个工作日
$537.17
详细
小鼠 非结合性 ICC, IF, IHC, IHC (p), WB   0.1 mL Log in to see 7至9个工作日
$538.13
详细

通过反应活性、应用领域、克隆类型和共轭标记 MYCN 抗体

特性 应用范围 宿主 克隆类型 标记
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引用最多的anti-MYCN 抗体

  1. Human Monoclonal MYCN Primary Antibody for ChIP, CyTOF - ABIN152254 : Tasseva, Cole, Vance: N-Myc and SP regulate phosphatidylserine synthase-1 expression in brain and glial cells. in The Journal of biological chemistry 2011 (PubMed)
    Show all 3 Pubmed References

  2. Mouse (Murine) Polyclonal MYCN Primary Antibody for ICC, IF - ABIN256650 : Sjostrom, Finn, Hahn, Rowitch, Kenney: The Cdk1 complex plays a prime role in regulating N-myc phosphorylation and turnover in neural precursors. in Developmental cell 2005 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal MYCN Primary Antibody for WB - ABIN391590 : Li, Sun, Chen, Squires, Nowroozizadeh, Liang, Huang: p53 Mutation Directs AURKA Overexpression via miR-25 and FBXW7 in Prostatic Small Cell Neuroendocrine Carcinoma. in Molecular cancer research : MCR 2015 (PubMed)

  4. Human Polyclonal MYCN Primary Antibody for IF (p), IHC (p) - ABIN760676 : Ramraj, Aravindan, Somasundaram, Herman, Natarajan, Aravindan: Serum-circulating miRNAs predict neuroblastoma progression in mouse model of high-risk metastatic disease. in Oncotarget 2016 (PubMed)

更多抗MYCN的相互作用对抗体

Human Mycn (MYCN) interaction partners

  1. Results establish evidence that high MYCN amplification can be present in retinoblastoma with or without coding sequence mutations in the RB1 (显示 RB1 抗体) gene.

  2. USP7 (显示 USP7 抗体) deubiquitinates MYCN to enhance its stability and transcriptional activity in neuroblastoma (显示 ARHGEF16 抗体).

  3. The study conducted metabolic profiling of pre-malignant sympathetic ganglia and tumors derived from the TH-MYCN mouse model of neuroblastoma (显示 ARHGEF16 抗体), that overexpresses human MYCN and compared to non-malignant ganglia from wildtype littermates. These results identify enhanced glutathione biosynthesis as a selective metabolic adaptation required for initiation of MYCN-driven neuroblastoma (显示 ARHGEF16 抗体).

  4. Many prognostic signatures for neuroblastoma (显示 ARHGEF16 抗体) are confounded by MYCN amplification.

  5. Increasing MYCN copy number is associated with an increasingly higher rate of unfavorable clinical/biological features, with 11q aberration being an exception. Patients with MYCN gain appear to have inferior outcomes, especially in otherwise more favorable groups.

  6. miR (显示 MLXIP 抗体)-21 enhances chemo-resistance in tongue cancer cells via directly targeting CADM1 (显示 CADM1 抗体), and an inverse correlation between miR (显示 MLXIP 抗体)-21 and CADM1 (显示 CADM1 抗体) expression in vivo. MiR (显示 MLXIP 抗体)-21 overexpression is attributed to MYCN-mediated transcriptional regulation, which is also predictive for a worse prognosis in tongue cancer

  7. LMO1 (显示 LMO1 抗体) is an important oncogene (显示 RAB1A 抗体) that promotes neuroblastoma (显示 ARHGEF16 抗体) initiation, progression, and widespread metastatic dissemination.

  8. our results identify DOT1L (显示 DOT1L 抗体) as a novel cofactor in N-Myc-mediated transcriptional activation of target genes and neuroblastoma (显示 ARHGEF16 抗体) oncogenesis. Furthermore, they characterize DOT1L (显示 DOT1L 抗体) inhibitors as novel anticancer agents against MYCN-amplified neuroblastoma (显示 ARHGEF16 抗体).

  9. CCCTC-binding factor (CTCF (显示 CTCF 抗体)) targets the binding sites within MYCN promoter to facilitate its expression in neuroblastoma (显示 ARHGEF16 抗体) (NB) cells.

  10. PAX3 (显示 PAX3 抗体)-FOXO1 (显示 FOXO1 抗体) collaborates with MYCN during early rhabdomyosarcoma (RMS) tumourigenesis to dysregulate proliferation and inhibit myogenic differentiation and cell death.

Mouse (Murine) Mycn (MYCN) interaction partners

  1. the role of N-myc in mouse lens development, was examined.

  2. Using comparative genomic hybridization, authors found that NCC (显示 SLC12A3 抗体)-derived NBL (显示 NUMBL 抗体) tumors in mice acquired copy number gains and losses that are syntenic to those observed in human MYCN-amplified NBL (显示 NUMBL 抗体) including 17q gain, 2p gain and loss of 1p36.

  3. a Mycn target gene encoding the miR (显示 MLXIP 抗体) cluster miR-17~92, while most retinoblastomas reemerged without clear genetic alterations in either Mycn or known Mycn targets. This Rb/MYCN model recapitulates key genetic driver alterations seen in human retinoblastoma and reveals the emergence of MYCN independence in an initially MYCN-driven tumor.

  4. The findings reveal a PLK1 (显示 PLK1 抗体)-Fbw7 (显示 FBXW7 抗体)-Myc (显示 MYC 抗体) signaling circuit that underlies tumorigenesis and validate PLK1 (显示 PLK1 抗体) inhibitors, alone or with Bcl2 (显示 BCL2 抗体) antagonists, as potential effective therapeutics for MYC (显示 MYC 抗体)-overexpressing cancers.

  5. ALKR1275Q cooperated with MYCN in the development of aggressive NB, possibly by downregulating the expression of ECM (显示 MMRN1 抗体)/BM-associated genes and by conferring malignant potentials to MYCN-expressing cells.

  6. Reuslts show that N-Myc overexpression leads to the development of poorly differentiated, invasive prostate cancer that is molecularly similar to human NEPC.

  7. Thus, this synergistic effect of ZD55-shMYCN in combination with doxorubicin provides a novel therapy strategy for doxorubicin-resistant neuroblastoma (显示 ARHGEF16 抗体), and is a promising approach for further clinical development.

  8. demonstrate a critical link between Myc (显示 MYC 抗体)/Mycn gene activity and glycolysis in spermatogonial stem cell self-renewal

  9. Loss of N-myc significantly impairs the Sonic hedgehog (显示 SHH 抗体) signaling pathway and disrupts the expression of cell cycle effectors with a significant reduction of Ccnd2 (显示 CCND2 抗体).

  10. Study shows that ground-state embryonic stem cells express low Myc (显示 MYC 抗体) levels. Deletion of both c-myc (显示 MYC 抗体) and N-myc activity strongly decreases transcription, splicing, and protein synthesis, leading to proliferation arrest; process is reversible and occurs without affecting pluripotency, suggesting that Myc (显示 MYC 抗体)-depleted stem cells enter a state of dormancy.

MYCN 抗原简介

蛋白简介

This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas.

Gene names and symbols associated with anti-Mycn (MYCN) 抗体

  • MYCN proto-oncogene, bHLH transcription factor (MYCN) 抗体
  • v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (MYCN) 抗体
  • v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived (Mycn) 抗体
  • MYCN proto-oncogene, bHLH transcription factor (Mycn) 抗体
  • olfactory receptor 8S1 (LOC515887) 抗体
  • MYCN proto-oncogene, bHLH transcription factor (mycn) 抗体
  • MYCN proto-oncogene, bHLH transcription factor S homeolog (mycn.S) 抗体
  • bHLHe37 抗体
  • c-nmyc 抗体
  • fb57a02 抗体
  • MODED 抗体
  • mycn 抗体
  • mycn-a 抗体
  • mycn-b 抗体
  • mycna 抗体
  • MYCNOT 抗体
  • N-myc 抗体
  • Nmuc1 抗体
  • Nmyc 抗体
  • Nmyc-1 抗体
  • nmyc1 抗体
  • ODED 抗体
  • wu:fb57a02 抗体
  • XN-myc 抗体
  • xN-myc1 抗体
  • XNmyc 抗体
  • zgc:85706 抗体

Protein level used designations for anti-Mycn (MYCN) 抗体

N-myc proto-oncogene protein , class E basic helix-loop-helix protein 37 , neuroblastoma MYC oncogene , neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene , oncogene NMYC , pp65/67 , v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived , v-myc myelocytomatosis viral related oncogene, neuroblastoma derived , N-myc protein , neuroblastoma myc-related oncogene 1 , Avian myelocytomatosis viral (v-myc) related oncogene neuroblastoma derived (Nmyc) , Avian myelocytomatosis viral (v-myc) related oncogene, neuroblastoma derived (Nmyc) , N-myc-like protein , v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog , MYCN proto-oncogene, bHLH transcription factor S homeolog , v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog S homeolog , v-myc myelocytomatosis viral related oncogene, neuroblastoma derived, a

GENE ID SPECIES
4613 Homo sapiens
482978 Canis lupus familiaris
421948 Gallus gallus
18109 Mus musculus
298894 Rattus norvegicus
515887 Bos taurus
252851 Danio rerio
380041 Xenopus laevis
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