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MYCN is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. 再加上，我们可以发MYCN 蛋白 (7) 和 MYCN 试剂盒 (6)和数多这个蛋白质的别的产品。
Showing 10 out of 98 products:
Human Monoclonal MYCN Primary Antibody for ChIP, CyTOF - ABIN152254
Tasseva, Cole, Vance: N-Myc and SP regulate phosphatidylserine synthase-1 expression in brain and glial cells. in The Journal of biological chemistry 2011
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Mouse (Murine) Polyclonal MYCN Primary Antibody for ICC, IF - ABIN256650
Sjostrom, Finn, Hahn, Rowitch, Kenney: The Cdk1 complex plays a prime role in regulating N-myc phosphorylation and turnover in neural precursors. in Developmental cell 2005
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Human Polyclonal MYCN Primary Antibody for WB - ABIN391590
Li, Sun, Chen, Squires, Nowroozizadeh, Liang, Huang: p53 Mutation Directs AURKA Overexpression via miR-25 and FBXW7 in Prostatic Small Cell Neuroendocrine Carcinoma. in Molecular cancer research : MCR 2015
Human Polyclonal MYCN Primary Antibody for IF (p), IHC (p) - ABIN760676
Ramraj, Aravindan, Somasundaram, Herman, Natarajan, Aravindan: Serum-circulating miRNAs predict neuroblastoma progression in mouse model of high-risk metastatic disease. in Oncotarget 2016
Results establish evidence that high MYCN amplification can be present in retinoblastoma with or without coding sequence mutations in the RB1 (显示 RB1 抗体) gene.
USP7 (显示 USP7 抗体) deubiquitinates MYCN to enhance its stability and transcriptional activity in neuroblastoma (显示 ARHGEF16 抗体).
The study conducted metabolic profiling of pre-malignant sympathetic ganglia and tumors derived from the TH-MYCN mouse model of neuroblastoma (显示 ARHGEF16 抗体), that overexpresses human MYCN and compared to non-malignant ganglia from wildtype littermates. These results identify enhanced glutathione biosynthesis as a selective metabolic adaptation required for initiation of MYCN-driven neuroblastoma (显示 ARHGEF16 抗体).
Many prognostic signatures for neuroblastoma (显示 ARHGEF16 抗体) are confounded by MYCN amplification.
Increasing MYCN copy number is associated with an increasingly higher rate of unfavorable clinical/biological features, with 11q aberration being an exception. Patients with MYCN gain appear to have inferior outcomes, especially in otherwise more favorable groups.
miR (显示 MLXIP 抗体)-21 enhances chemo-resistance in tongue cancer cells via directly targeting CADM1 (显示 CADM1 抗体), and an inverse correlation between miR (显示 MLXIP 抗体)-21 and CADM1 (显示 CADM1 抗体) expression in vivo. MiR (显示 MLXIP 抗体)-21 overexpression is attributed to MYCN-mediated transcriptional regulation, which is also predictive for a worse prognosis in tongue cancer
LMO1 (显示 LMO1 抗体) is an important oncogene (显示 RAB1A 抗体) that promotes neuroblastoma (显示 ARHGEF16 抗体) initiation, progression, and widespread metastatic dissemination.
our results identify DOT1L (显示 DOT1L 抗体) as a novel cofactor in N-Myc-mediated transcriptional activation of target genes and neuroblastoma (显示 ARHGEF16 抗体) oncogenesis. Furthermore, they characterize DOT1L (显示 DOT1L 抗体) inhibitors as novel anticancer agents against MYCN-amplified neuroblastoma (显示 ARHGEF16 抗体).
CCCTC-binding factor (CTCF (显示 CTCF 抗体)) targets the binding sites within MYCN promoter to facilitate its expression in neuroblastoma (显示 ARHGEF16 抗体) (NB) cells.
PAX3 (显示 PAX3 抗体)-FOXO1 (显示 FOXO1 抗体) collaborates with MYCN during early rhabdomyosarcoma (RMS) tumourigenesis to dysregulate proliferation and inhibit myogenic differentiation and cell death.
the role of N-myc in mouse lens development, was examined.
Using comparative genomic hybridization, authors found that NCC (显示 SLC12A3 抗体)-derived NBL (显示 NUMBL 抗体) tumors in mice acquired copy number gains and losses that are syntenic to those observed in human MYCN-amplified NBL (显示 NUMBL 抗体) including 17q gain, 2p gain and loss of 1p36.
a Mycn target gene encoding the miR (显示 MLXIP 抗体) cluster miR-17~92, while most retinoblastomas reemerged without clear genetic alterations in either Mycn or known Mycn targets. This Rb/MYCN model recapitulates key genetic driver alterations seen in human retinoblastoma and reveals the emergence of MYCN independence in an initially MYCN-driven tumor.
The findings reveal a PLK1 (显示 PLK1 抗体)-Fbw7 (显示 FBXW7 抗体)-Myc (显示 MYC 抗体) signaling circuit that underlies tumorigenesis and validate PLK1 (显示 PLK1 抗体) inhibitors, alone or with Bcl2 (显示 BCL2 抗体) antagonists, as potential effective therapeutics for MYC (显示 MYC 抗体)-overexpressing cancers.
ALKR1275Q cooperated with MYCN in the development of aggressive NB, possibly by downregulating the expression of ECM (显示 MMRN1 抗体)/BM-associated genes and by conferring malignant potentials to MYCN-expressing cells.
Reuslts show that N-Myc overexpression leads to the development of poorly differentiated, invasive prostate cancer that is molecularly similar to human NEPC.
Thus, this synergistic effect of ZD55-shMYCN in combination with doxorubicin provides a novel therapy strategy for doxorubicin-resistant neuroblastoma (显示 ARHGEF16 抗体), and is a promising approach for further clinical development.
demonstrate a critical link between Myc (显示 MYC 抗体)/Mycn gene activity and glycolysis in spermatogonial stem cell self-renewal
Loss of N-myc significantly impairs the Sonic hedgehog (显示 SHH 抗体) signaling pathway and disrupts the expression of cell cycle effectors with a significant reduction of Ccnd2 (显示 CCND2 抗体).
Study shows that ground-state embryonic stem cells express low Myc (显示 MYC 抗体) levels. Deletion of both c-myc (显示 MYC 抗体) and N-myc activity strongly decreases transcription, splicing, and protein synthesis, leading to proliferation arrest; process is reversible and occurs without affecting pluripotency, suggesting that Myc (显示 MYC 抗体)-depleted stem cells enter a state of dormancy.
This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas.
N-myc proto-oncogene protein
, class E basic helix-loop-helix protein 37
, neuroblastoma MYC oncogene
, neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene
, oncogene NMYC
, v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived
, v-myc myelocytomatosis viral related oncogene, neuroblastoma derived
, N-myc protein
, neuroblastoma myc-related oncogene 1
, Avian myelocytomatosis viral (v-myc) related oncogene neuroblastoma derived (Nmyc)
, Avian myelocytomatosis viral (v-myc) related oncogene, neuroblastoma derived (Nmyc)
, N-myc-like protein
, v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
, MYCN proto-oncogene, bHLH transcription factor S homeolog
, v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog S homeolog
, v-myc myelocytomatosis viral related oncogene, neuroblastoma derived, a