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MYCN is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. 再加上，我们可以发MYCN 蛋白 (10) 和 MYCN 试剂盒 (6)和数多这个蛋白质的别的产品。
Showing 10 out of 96 products:
Human Monoclonal MYCN Primary Antibody for ChIP, CyTOF - ABIN152254
Tasseva, Cole, Vance: N-Myc and SP regulate phosphatidylserine synthase-1 expression in brain and glial cells. in The Journal of biological chemistry 2011
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Mouse (Murine) Polyclonal MYCN Primary Antibody for ICC, IF - ABIN256650
Sjostrom, Finn, Hahn, Rowitch, Kenney: The Cdk1 complex plays a prime role in regulating N-myc phosphorylation and turnover in neural precursors. in Developmental cell 2005
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Human Polyclonal MYCN Primary Antibody for EIA, WB - ABIN453206
Alvarez-Rodríguez, Pons: Expression of the proneural gene encoding Mash1 suppresses MYCN mitotic activity. in Journal of cell science 2009
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Human Polyclonal MYCN Primary Antibody for WB - ABIN391590
Li, Sun, Chen, Squires, Nowroozizadeh, Liang, Huang: p53 Mutation Directs AURKA Overexpression via miR-25 and FBXW7 in Prostatic Small Cell Neuroendocrine Carcinoma. in Molecular cancer research : MCR 2015
Human Polyclonal MYCN Primary Antibody for IF (p), IHC (p) - ABIN760676
Ramraj, Aravindan, Somasundaram, Herman, Natarajan, Aravindan: Serum-circulating miRNAs predict neuroblastoma progression in mouse model of high-risk metastatic disease. in Oncotarget 2016
Cow (Bovine) Polyclonal MYCN Primary Antibody for WB - ABIN2779428
Hansford, Thomas, Keating, Burkhart, Peaston, Norris, Haber, Armati, Weiss, Marshall: Mechanisms of embryonal tumor initiation: distinct roles for MycN expression and MYCN amplification. in Proceedings of the National Academy of Sciences of the United States of America 2004
LMO1 (显示 LMO1 抗体) is an important oncogene (显示 RAB1A 抗体) that promotes neuroblastoma (显示 ARHGEF16 抗体) initiation, progression, and widespread metastatic dissemination.
our results identify DOT1L (显示 DOT1L 抗体) as a novel cofactor in N-Myc-mediated transcriptional activation of target genes and neuroblastoma (显示 ARHGEF16 抗体) oncogenesis. Furthermore, they characterize DOT1L (显示 DOT1L 抗体) inhibitors as novel anticancer agents against MYCN-amplified neuroblastoma (显示 ARHGEF16 抗体).
CCCTC-binding factor (CTCF (显示 CTCF 抗体)) targets the binding sites within MYCN promoter to facilitate its expression in neuroblastoma (显示 ARHGEF16 抗体) (NB) cells.
PAX3 (显示 PAX3 抗体)-FOXO1 (显示 FOXO1 抗体) collaborates with MYCN during early rhabdomyosarcoma (RMS) tumourigenesis to dysregulate proliferation and inhibit myogenic differentiation and cell death.
The findings reveal a PLK1 (显示 PLK1 抗体)-Fbw7 (显示 FBXW7 抗体)-Myc (显示 MYC 抗体) signaling circuit that underlies tumorigenesis and validate PLK1 (显示 PLK1 抗体) inhibitors, alone or with Bcl2 (显示 BCL2 抗体) antagonists, as potential effective therapeutics for MYC (显示 MYC 抗体)-overexpressing cancers.
Results show that N-Myc overexpression leads to the development of poorly differentiated, invasive prostate cancer that is molecularly similar to human NEPC.
Rac (显示 AKT1 抗体) activity may be an important determinant of metastatic capability in subsets of neuroblastoma (显示 ARHGEF16 抗体) cells lacking MYCN amplification.
MYCN Gene Amplification is associated with Neuroblastoma (显示 ARHGEF16 抗体).
MYCN overexpression combined with activated anaplastic lymphoma kinase (ALK (显示 ALK 抗体)) is sufficient to induce neuroblastoma (显示 ARHGEF16 抗体) (NB) in mouse sympathoadrenal cells
MYCN amplification can be heterogeneous between tumor sites, during tumor progression or following treatment, challenging the notion that MYCN copy number does not change for a particular neuroblastoma (显示 ARHGEF16 抗体).
the role of N-myc in mouse lens development, was examined.
Using comparative genomic hybridization, authors found that NCC (显示 SLC12A3 抗体)-derived NBL (显示 NUMBL 抗体) tumors in mice acquired copy number gains and losses that are syntenic to those observed in human MYCN-amplified NBL (显示 NUMBL 抗体) including 17q gain, 2p gain and loss of 1p36.
a Mycn target gene encoding the miR (显示 MLXIP 抗体) cluster miR-17~92, while most retinoblastomas reemerged without clear genetic alterations in either Mycn or known Mycn targets. This Rb/MYCN model recapitulates key genetic driver alterations seen in human retinoblastoma and reveals the emergence of MYCN independence in an initially MYCN-driven tumor.
ALKR1275Q cooperated with MYCN in the development of aggressive NB, possibly by downregulating the expression of ECM (显示 MMRN1 抗体)/BM-associated genes and by conferring malignant potentials to MYCN-expressing cells.
Reuslts show that N-Myc overexpression leads to the development of poorly differentiated, invasive prostate cancer that is molecularly similar to human NEPC.
Thus, this synergistic effect of ZD55-shMYCN in combination with doxorubicin provides a novel therapy strategy for doxorubicin-resistant neuroblastoma (显示 ARHGEF16 抗体), and is a promising approach for further clinical development.
demonstrate a critical link between Myc (显示 MYC 抗体)/Mycn gene activity and glycolysis in spermatogonial stem cell self-renewal
Loss of N-myc significantly impairs the Sonic hedgehog (显示 SHH 抗体) signaling pathway and disrupts the expression of cell cycle effectors with a significant reduction of Ccnd2 (显示 CCND2 抗体).
Study shows that ground-state embryonic stem cells express low Myc (显示 MYC 抗体) levels. Deletion of both c-myc (显示 MYC 抗体) and N-myc activity strongly decreases transcription, splicing, and protein synthesis, leading to proliferation arrest; process is reversible and occurs without affecting pluripotency, suggesting that Myc (显示 MYC 抗体)-depleted stem cells enter a state of dormancy.
This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas.
N-myc proto-oncogene protein
, class E basic helix-loop-helix protein 37
, neuroblastoma MYC oncogene
, neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene
, oncogene NMYC
, v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived
, v-myc myelocytomatosis viral related oncogene, neuroblastoma derived
, Avian myelocytomatosis viral (v-myc) related oncogene neuroblastoma derived (Nmyc)
, Avian myelocytomatosis viral (v-myc) related oncogene, neuroblastoma derived (Nmyc)
, N-myc protein
, neuroblastoma myc-related oncogene 1