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The protein encoded by MADCAM1 is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and infl. 再加上，我们可以发Mucosal Vascular Addressin Cell Adhesion Molecule 1 试剂盒 (40) 和 Mucosal Vascular Addressin Cell Adhesion Molecule 1 蛋白 (9)和数多这个蛋白质的别的产品。
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Human Monoclonal MADCAM1 Primary Antibody for EIA, FACS - ABIN120238
Leung, Lehnert, Kanwar, Yang, Mon, McNeil, Krissansen: Bioassay detects soluble MAdCAM-1 in body fluids. in Immunology and cell biology 2004
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Human Monoclonal MADCAM1 Primary Antibody for EIA, FACS - ABIN320242
Leung, Greene, Ni, Raymond, Lehnert, Langley, Krissansen: Cloning of the mucosal addressin MAdCAM-1 from human brain: identification of novel alternatively spliced transcripts. in Immunology and cell biology 1997
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Human Monoclonal MADCAM1 Primary Antibody for EIA, Func - ABIN120237
Olloquequi, Montes, Prats, Rodríguez, Montero, García-Valero, Ferrer: Significant increase of CD57+ cells in pulmonary lymphoid follicles of COPD patients. in The European respiratory journal 2011
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Mouse (Murine) Monoclonal MADCAM1 Primary Antibody for FACS, IHC (fro) - ABIN319645
Briskin, McEvoy, Butcher: MAdCAM-1 has homology to immunoglobulin and mucin-like adhesion receptors and to IgA1. in Nature 1993
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The results uncovered a previously unknown role of integrin a4b7-MAdCAM-1 interactions as drivers of colitis by directing inflammatory monocytes into the colon.
beta7 integrin, when expressed by hematopoietic stem cells (HSC (显示 FUT1 抗体)), interacted with its endothelial ligand MAdCAM-1 in the Bone marrow microenvironment, thereby promoting HSC (显示 FUT1 抗体) homing and engraftment.
Nkx2-3 deficiency reprograms the endothelial addressin preference for lymphocyte homing in Peyer's patches.
findings indicate that alpha4beta7*IgG can be used as a probe for functional MAdCAM-1 expressed on HEVs in GALT (显示 GALT 抗体) and could potentially serve as an anti-inflammatory drug inhibiting GALT (显示 GALT 抗体)-specific lymphocyte migration
ectopic expression of MAdCAM-1 at the BBB (显示 ALMS1 PLURAL_@4205@) does not increase alpha4beta7-integrin-mediated immune cell trafficking into the CNS during MOG (显示 MOG PLURAL_@4205@)(aa35-55)-induced experimental autoimmune encephalomyelitis
Observed a significant decrease in expression of ICAM-1 (显示 ICAM1 抗体) and MAdCAM-1 mRNA/protein in lactobacillus plantarum treated colitis.
results suggest that AT1R (显示 AGTRAP 抗体) regulates the expression of MAdCAM-1 under colonic inflammatory conditions through regulation of the translocation of NF-kappaB (显示 NFKB1 抗体) into the nucleus
Lymphocyte binding to MAdCAM-1 via alpha4beta7 integrin activates a signal transduction pathway involving tyrosine phosphorylation of paxillin (显示 PXN 抗体) and p105(Cas-L (显示 NEDD9 抗体))
Mucosal addressin cell adhesion molecule 1 plays an unexpected role in the development of mouse guard hair.
spatial heterogeneity of MAdCAM-1 and VCAM-1 (显示 VCAM1 抗体) activation following TNF-alpha (显示 TNF 抗体) challenge may promote specific T lymphocyte recruitment in the inflamed colonic mucosa
Both the ACT-1 (显示 TRAF3IP2 抗体) assay and the MAdCAM-1 assay demonstrated acceptable reproducibility and repeatability. The assays were sufficiently stable to allow for clinical use. During clinical testing the assays demonstrated that vedolizumab was able to saturate peripheral cells at all doses tested.
Doxo-induced apoptosis has a role in inhibiting hepatocellular carcinoma by targeting Madcam1 and AKT (显示 AKT1 抗体) and blocking protein translation initiation
MADCAM1 is up-regulated in liver cirrhosis with expression on peribiliary vascular plexus and lymphoid aggregates
Domain 1 of mucosal addressin cell adhesion molecule (显示 MCAM 抗体) has an I1-set fold and a flexible integrin-binding loop.
Findings suggest that the inactive alpha4beta7 and alpha4beta7 activated by different stimuli have distinct conformations with different structural requirements for MAdCAM-1 binding.
Ca2 (显示 CA2 抗体)+ is essential for cell tethering in flow and rolling interactions through alpha 4 integrins with MAdCAM-1 as substrate; Mg2 (显示 MUC7 抗体)+ promotes firm adhesion of cells on MAdCAM-1 but with much lower tethering efficiency in shear flow.
A crystal structure for the two extracellular amino-terminal domains of human MAdCAM-1
more extensive expression of MAdCAM-1 in Crohn's disease (CrD (显示 CRX 抗体)), than in ulcerative colitis, which could contribute not only to mucosal inflammation, but also to transmural inflammation in CrD (显示 CRX 抗体).
MAdCAM-1/integrin alpha4beta7 homing system may participate in gastric inflammation in response to H pylori-infection and contributes to MALT formation, typically leading to the development of nodular gastritis.
PI3-K (显示 PIK3CA 抗体)/Akt (显示 AKT1 抗体) is involved in the gut (显示 GUSB 抗体)-specific differentiation of human intestinal microvascular endothelial cells, which results in expression of the mucosal addressin MAdCAM-1
The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full-length nature of some variants has not been determined.
mucosal vascular addressin cell adhesion molecule 1
, mucosal addressin cell adhesion molecule 1
, mucosal addressin cell adhesion molecule-1
, mucosal addressin cellular adhesion molecule-1