anti-Mucosal Vascular Addressin Cell Adhesion Molecule 1 (MADCAM1) 抗体

The protein encoded by MADCAM1 is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and infl. 再加上,我们可以发Mucosal Vascular Addressin Cell Adhesion Molecule 1 试剂盒 (40)Mucosal Vascular Addressin Cell Adhesion Molecule 1 蛋白 (9)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
MADCAM1 17123  
MADCAM1 8174 Q13477
MADCAM1 54266 O70540

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非结合性 IHC (fro), IHC (p), WB 100 μg Log in to see 26至32个工作日
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小鼠 非结合性 EIA, FACS, IHC (p), WB   0.2 mg Log in to see 29至35个工作日
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小鼠 非结合性 EIA, Func, FACS, IHC (p), WB   0.5 mg Log in to see 29至35个工作日
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小鼠 非结合性 EIA, FACS, IHC (p)   25 μg Log in to see 29至35个工作日
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小鼠 Biotin EIA, FACS   25 μg Log in to see 29至35个工作日
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小鼠 PE FACS   25 Tests Log in to see 29至35个工作日
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小鼠 FITC FACS   0.1 mg Log in to see 29至35个工作日
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小鼠 非结合性 EIA, FACS, WB   0.2 mg Log in to see 29至35个工作日
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非结合性 WB 100 μL Log in to see 24至29个工作日
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小鼠 大鼠 非结合性 FACS, IHC (fro), IP, WB   25 μg Log in to see 29至35个工作日
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通过反应活性、应用领域、克隆类型和共轭标记 MADCAM1 抗体

特性 应用范围 宿主 克隆类型 标记
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引用最多的anti-Mucosal Vascular Addressin Cell Adhesion Molecule 1 抗体

  1. Human Monoclonal MADCAM1 Primary Antibody for EIA, FACS - ABIN120238 : Leung, Lehnert, Kanwar, Yang, Mon, McNeil, Krissansen: Bioassay detects soluble MAdCAM-1 in body fluids. in Immunology and cell biology 2004 (PubMed)
    Show all 3 references for 120238

  2. Human Monoclonal MADCAM1 Primary Antibody for EIA, FACS - ABIN320242 : Leung, Greene, Ni, Raymond, Lehnert, Langley, Krissansen: Cloning of the mucosal addressin MAdCAM-1 from human brain: identification of novel alternatively spliced transcripts. in Immunology and cell biology 1997 (PubMed)
    Show all 3 references for 320242

  3. Human Monoclonal MADCAM1 Primary Antibody for EIA, Func - ABIN120237 : Olloquequi, Montes, Prats, Rodríguez, Montero, García-Valero, Ferrer: Significant increase of CD57+ cells in pulmonary lymphoid follicles of COPD patients. in The European respiratory journal 2011 (PubMed)
    Show all 3 references for 120237

  4. Mouse (Murine) Monoclonal MADCAM1 Primary Antibody for FACS, IHC (fro) - ABIN319645 : Briskin, McEvoy, Butcher: MAdCAM-1 has homology to immunoglobulin and mucin-like adhesion receptors and to IgA1. in Nature 1993 (PubMed)
    Show all 2 references for 319645

更多抗Mucosal Vascular Addressin Cell Adhesion Molecule 1的相互作用对抗体

Mouse (Murine) Mucosal Vascular Addressin Cell Adhesion Molecule 1 (MADCAM1) interaction partners

  1. The results uncovered a previously unknown role of integrin a4b7-MAdCAM-1 interactions as drivers of colitis by directing inflammatory monocytes into the colon.

  2. beta7 integrin, when expressed by hematopoietic stem cells (HSC (显示 FUT1 抗体)), interacted with its endothelial ligand MAdCAM-1 in the Bone marrow microenvironment, thereby promoting HSC (显示 FUT1 抗体) homing and engraftment.

  3. Nkx2-3 deficiency reprograms the endothelial addressin preference for lymphocyte homing in Peyer's patches.

  4. findings indicate that alpha4beta7*IgG can be used as a probe for functional MAdCAM-1 expressed on HEVs in GALT (显示 GALT 抗体) and could potentially serve as an anti-inflammatory drug inhibiting GALT (显示 GALT 抗体)-specific lymphocyte migration

  5. ectopic expression of MAdCAM-1 at the BBB (显示 ALMS1 PLURAL_@4205@) does not increase alpha4beta7-integrin-mediated immune cell trafficking into the CNS during MOG (显示 MOG PLURAL_@4205@)(aa35-55)-induced experimental autoimmune encephalomyelitis

  6. Observed a significant decrease in expression of ICAM-1 (显示 ICAM1 抗体) and MAdCAM-1 mRNA/protein in lactobacillus plantarum treated colitis.

  7. results suggest that AT1R (显示 AGTRAP 抗体) regulates the expression of MAdCAM-1 under colonic inflammatory conditions through regulation of the translocation of NF-kappaB (显示 NFKB1 抗体) into the nucleus

  8. Lymphocyte binding to MAdCAM-1 via alpha4beta7 integrin activates a signal transduction pathway involving tyrosine phosphorylation of paxillin (显示 PXN 抗体) and p105(Cas-L (显示 NEDD9 抗体))

  9. Mucosal addressin cell adhesion molecule 1 plays an unexpected role in the development of mouse guard hair.

  10. spatial heterogeneity of MAdCAM-1 and VCAM-1 (显示 VCAM1 抗体) activation following TNF-alpha (显示 TNF 抗体) challenge may promote specific T lymphocyte recruitment in the inflamed colonic mucosa

Human Mucosal Vascular Addressin Cell Adhesion Molecule 1 (MADCAM1) interaction partners

  1. Both the ACT-1 (显示 TRAF3IP2 抗体) assay and the MAdCAM-1 assay demonstrated acceptable reproducibility and repeatability. The assays were sufficiently stable to allow for clinical use. During clinical testing the assays demonstrated that vedolizumab was able to saturate peripheral cells at all doses tested.

  2. Doxo-induced apoptosis has a role in inhibiting hepatocellular carcinoma by targeting Madcam1 and AKT (显示 AKT1 抗体) and blocking protein translation initiation

  3. MADCAM1 is up-regulated in liver cirrhosis with expression on peribiliary vascular plexus and lymphoid aggregates

  4. Domain 1 of mucosal addressin cell adhesion molecule (显示 MCAM 抗体) has an I1-set fold and a flexible integrin-binding loop.

  5. Findings suggest that the inactive alpha4beta7 and alpha4beta7 activated by different stimuli have distinct conformations with different structural requirements for MAdCAM-1 binding.

  6. Ca2 (显示 CA2 抗体)+ is essential for cell tethering in flow and rolling interactions through alpha 4 integrins with MAdCAM-1 as substrate; Mg2 (显示 MUC7 抗体)+ promotes firm adhesion of cells on MAdCAM-1 but with much lower tethering efficiency in shear flow.

  7. A crystal structure for the two extracellular amino-terminal domains of human MAdCAM-1

  8. more extensive expression of MAdCAM-1 in Crohn's disease (CrD (显示 CRX 抗体)), than in ulcerative colitis, which could contribute not only to mucosal inflammation, but also to transmural inflammation in CrD (显示 CRX 抗体).

  9. MAdCAM-1/integrin alpha4beta7 homing system may participate in gastric inflammation in response to H pylori-infection and contributes to MALT formation, typically leading to the development of nodular gastritis.

  10. PI3-K (显示 PIK3CA 抗体)/Akt (显示 AKT1 抗体) is involved in the gut (显示 GUSB 抗体)-specific differentiation of human intestinal microvascular endothelial cells, which results in expression of the mucosal addressin MAdCAM-1

Mucosal Vascular Addressin Cell Adhesion Molecule 1 (MADCAM1) 抗原简介

蛋白简介

The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full-length nature of some variants has not been determined.

Gene names and symbols associated with MADCAM1

  • mucosal vascular addressin cell adhesion molecule 1 (MADCAM1) 抗体
  • mucosal vascular addressin cell adhesion molecule 1 (Madcam1) 抗体
  • mucosal vascular addressin cell adhesion molecule 1 (MADCAM-1) 抗体
  • AV211525 抗体
  • MACAM1 抗体
  • MADCAM1 抗体

Protein level used designations for MADCAM1

mucosal vascular addressin cell adhesion molecule 1 , MAdCAM-1 , mMAdCAM-1 , mucosal addressin cell adhesion molecule 1 , hMAdCAM-1 , mucosal addressin cell adhesion molecule-1 , rMAdCAM-1 , mucosal addressin cellular adhesion molecule-1

GENE ID SPECIES
789849 Bos taurus
17123 Mus musculus
8174 Homo sapiens
54266 Rattus norvegicus
100722478 Cavia porcellus
492312 Sus scrofa
485103 Canis lupus familiaris
527275 Bos taurus
100858236 Gallus gallus
654333 Ovis aries
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