Mannosidase, Alpha, Class 2B, Member 1 (MAN2B1) ELISA试剂盒

MAN2B1 encodes an enzyme that hydrolyzes terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. 再加上,我们可以发Mannosidase, Alpha, Class 2B, Member 1 抗体 (11)Mannosidase, Alpha, Class 2B, Member 1 蛋白 (10)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
小鼠 MAN2B1 MAN2B1 17159 O09159
大鼠 MAN2B1 MAN2B1 361378  
MAN2B1 4125 O00754

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产品编号 适用 灵敏度 范围 图像 规格 供应商 交付 价格 详细
3.9 pg/mL 15.6-1000 pg/mL Typical standard curve 96 Tests Log in to see 9至12个工作日
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Mouse (Murine) Mannosidase, Alpha, Class 2B, Member 1 (MAN2B1) interaction partners

  1. Mannose receptor (-/-) liver sinusoidal endothelial cells had markedly and significantly reduced enzyme activities for four out of five lysosomal enzymes tested, i.e., cathepsin-D, alpha-mannosidase, beta-hexosaminidase and arylsulfatase.

Human Mannosidase, Alpha, Class 2B, Member 1 (MAN2B1) interaction partners

  1. A novel heterozygous mutation (c.2013G>A; p.R638H) of MANBA (显示 MANBA ELISA试剂盒) was identified in patients with autosomal-dominant nystagmus. An additional mutation (c.2346T>A; p.L749H) in MANBA (显示 MANBA ELISA试剂盒) was found by screening patients with sporadic nystagmus.

  2. Our results indicate a correlation between the MAN2B1 genotypes and the cognitive function, upper limb coordination, balance, FVC% and the storage of oligosaccharides in CSF (显示 CSF2 ELISA试剂盒).

  3. The results showed that the alpha-mannosidosis patient has compound heterozygous mutations in the MAN2B1 gene

  4. MAN2B1 is targeted to the vacuole without passing through the Golgi complex.

  5. Expressed MAN2B1 and MAN2B2 (显示 MAN2B2 ELISA试剂盒) in Drosophila S2 cells and functionally characterized them. MAN2B1 and MAN2B2 (显示 MAN2B2 ELISA试剂盒) were significantly inhibited by the class II alpha-mannosidase inhibitors, swainsonine and mannostatin A.

  6. 5 new mutations were found in the MAN2B1 gene: c.157G>T, c.562C>T, c.599A>T, c.293dupA, c.2402G>A (p.E53X, p.R188X, p.H200L, p.Y99VfsX61, p.G801D). p.H200L could involve the catalytic mechanism. p.G801D would affect correct folding.

Cow (Bovine) Mannosidase, Alpha, Class 2B, Member 1 (MAN2B1) interaction partners

Mannosidase, Alpha, Class 2B, Member 1 (MAN2B1) 抗原简介

Antigen Summary

This gene encodes an enzyme that hydrolyzes terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. Its activity is necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover and it is member of family 38 of glycosyl hydrolases. The full length protein is processed in two steps. First, a 49 aa leader sequence is cleaved off and the remainder of the protein is processed into 3 peptides of 70 kDa, 42 kDa (D) and 13/15 kDa (E). Next, the 70 kDa peptide is further processed into three peptides (A, B and C). The A, B and C peptides are disulfide-linked. Defects in this gene have been associated with lysosomal alpha-mannosidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with MAN2B1

  • mannosidase, alpha, class 2B, member 1 (MAN2B1) 抗体
  • mannosidase, alpha, class 2B, member 1 (man2b1) 抗体
  • mannosidase 2, alpha B1 (Man2b1) 抗体
  • mannosidase, alpha, class 2B, member 1 (Man2b1) 抗体
  • AW107687 抗体
  • Laman 抗体
  • MANB 抗体

Protein level used designations for MAN2B1

mannosidase, alpha, class 2B, member 1 , lysosomal alpha-mannosidase (109.3 kD) (XF355) , lysosomal alpha-mannosidase , lysosomal alpha-mannosidase-like , lysosomal acid alpha-mannosidase , mannosidase alpha class 2B member 1 , mannosidase alpha-B , mannosidase 2, alpha B1 , mannosidase, alpha B, lysosomal , laman

GENE ID SPECIES
484932 Canis lupus familiaris
779924 Xenopus (Silurana) tropicalis
100010377 Monodelphis domestica
100174476 Pongo abelii
100395073 Callithrix jacchus
100598622 Nomascus leucogenys
17159 Mus musculus
100718205 Cavia porcellus
361378 Rattus norvegicus
4125 Homo sapiens
282272 Bos taurus
493697 Felis catus
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