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The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis. 再加上，我们可以发MLF1IP 抗体 (77) 和 MLF1IP 蛋白 (7)和数多这个蛋白质的别的产品。
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This study provides new insights and evidences that MLF1IP over-expression plays important roles in progression of luminal breast cancer. However, the precise cellular mechanisms for MLF1IP in luminal breast cancer need to be further explored.
MLF1IP promotes normal erythroid proliferation and (显示 IGF2BP3 ELISA试剂盒) is involved in the pathogenesis of polycythemia vera.
MLF1IP significantly promotes prostate cancer cell proliferation and colony formation and significantly inhibits apoptosis without affecting cell cycle phase arrest in prostate cancer cell lines
Plk1 (显示 PLK1 ELISA试剂盒) regulates the timing of the delocalization and ultimate destruction of the PBIP1.CENP-Q (显示 CENPQ ELISA试剂盒) complex.
Data propose that CENP-P (显示 CENPP ELISA试剂盒)/O/R/Q/U self-assembles on kinetochores with varying stoichiometry and undergoes a pre-mitotic maturation step that could be important for kinetochores switching into the correct conformation for microtubule-attachment.
Mammalian polo-like kinase 1 (显示 PLK1 ELISA试剂盒)-dependent regulation of the PBIP1-CENP-Q (显示 CENPQ ELISA试剂盒) complex at kinetochores.
CENP-U is a novel microtubule binding protein and plays an important role in kinetochore-microtubule attachment through its interaction with Hec1
a possible role for MLF1IP deregulation in the genesis of erythroleukemias
MLF1IP was found in glioblastomas where it was co-localized with MLF1 (显示 MLF1 ELISA试剂盒) and nestin (显示 NES ELISA试剂盒). Moreover, it was elevated in the contralateral brain where no tumor cells occurred, suggesting a role in glioma pathogenesis and potentially in other types of malignancies.
Plk1 (显示 PLK1 ELISA试剂盒) self-regulates the Plk1 (显示 PLK1 ELISA试剂盒)-PBIP1 interaction to timely localize to the kinetochores and promote proper chromosome segregation.
MLF1IP transgenic mice developed polycythemia vera (显示 IGF2BP3 ELISA试剂盒) (PV)-like symptoms based on the analysis of hematological features, suggesting that MLF1IP is partially involved in the pathogenesis of PV.
MLF1 (显示 MLF1 ELISA试剂盒)-IP expression at about 50% of its normal level is sufficient to sustain mice life and the development of their immune system without apparent abnormalities.
The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis. All active centromeres are characterized by the presence of long arrays of nucleosomes in which CENPA (MIM 117139) replaces histone H3 (see MIM 601128). MLF1IP, or CENPU, is an additional factor required for centromere assembly (Foltz et al., 2006
MLF1 interacting protein
, centromere protein U-like
, KSHV latent nuclear antigen interacting protein 1
, KSHV latent nuclear antigen-interacting protein 1
, MLF1-interacting protein
, centromere protein U
, centromere protein of 50 kDa
, interphase centromere complex protein 24
, polo-box-interacting protein 1
, myeloid leukemia factor 1 interacting protein
, centromere protein p50