anti-MAGE-Like 2 (MAGEL2) 抗体

Prader-Willi syndrome (PWS) is caused by the loss of expression of imprinted genes in chromosome 15q11-q13 region. 再加上,我们可以发MAGE-Like 2 蛋白 (2)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID
MAGEL2 54551
MAGEL2 679875
MAGEL2 27385

antibodies-online.cn销售最多的anti-MAGE-Like 2 抗体

Showing 10 out of 45 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
非结合性 EIA, IHC (p), WB 0.4 mL Log in to see 29至35个工作日
非结合性 IHC (p), WB MAGEL2 Antibody (D514) (ABIN390122) western blot analysis in K562 cell line lysates (35 µg/lane).This demonstrates the MAGEL2 antibody detected the MAGEL2 protein (arrow). MAGEL2 Antibody (C-term) (ABIN390122)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL Log in to see 5至8个工作日
Cow 非结合性 WB WB Suggested Anti-MAGEL2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: A549 cell lysate WB Suggested Anti-MAGEL2  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.12500  Positive Control: A549 cell lysate 100 μL Log in to see 24至29个工作日
非结合性 IHC (p), ELISA Human Placenta (formalin-fixed, paraffin-embedded) stained with MAGEL2 antibody ABIN214669 at 10 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 29至35个工作日
非结合性 EIA, IHC (p) 50 μg Log in to see 29至35个工作日
Cow 非结合性 WB 50 μg Log in to see 29至35个工作日
非结合性 IHC (p), IHC, ELISA Immunohistochemistry-Paraffin: MAGEL2 Antibody [NBP1-02509] - Staining of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. 0.05 mg Log in to see 25至31个工作日
Alexa Fluor 488 IF (p)   100 μL Log in to see 14至17个工作日
Alexa Fluor 555 IF (p)   100 μL Log in to see 14至17个工作日
Alexa Fluor 594 IF (p)   100 μL Log in to see 14至17个工作日

通过反应活性、应用领域、克隆类型和共轭标记 MAGEL2 抗体

特性 应用范围 宿主 克隆类型 标记
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引用最多的anti-MAGE-Like 2 抗体

  1. Human Polyclonal MAGEL2 Primary Antibody for EIA, IHC (p) - ABIN358645 : De Smet, Lurquin, van der Bruggen, De Plaen, Brasseur, Boon: Sequence and expression pattern of the human MAGE2 gene. in Immunogenetics 1994 (PubMed)
    Show all 4 references for 358645

  2. Human Polyclonal MAGEL2 Primary Antibody for IHC (p), WB - ABIN390122 : Lee, Kozlov, Hernandez, Chamberlain, Brannan, Stewart, Wevrick: Expression and imprinting of MAGEL2 suggest a role in Prader-willi syndrome and the homologous murine imprinting phenotype. in Human molecular genetics 2000 (PubMed)
    Show all 2 references for 390122

更多抗MAGE-Like 2的相互作用对抗体

Human MAGE-Like 2 (MAGEL2) interaction partners

  1. Immunohistochemistry using D2-40 monoclonal antibody (MAGE2) and anti-MITF1 increased detection of lymphovascular invasion in primary cutaneous melanoma.

  2. A similar pro (显示 LEP 抗体)gressive loss of leptin sensitivity caused by loss of MAGEL2 in children with Prader-Willi s (显示 LEP 抗体)yndrome could ex (显示 POMC 抗体)plain the delayed onset of increased appetite and weight gain in this complex disorder.

  3. We find that MAGE-A2 (显示 MAGEA2 抗体) interacts with MDM2 (显示 MDM2 抗体) via the N-terminal p53 (显示 TP53 抗体)-binding pocket and the RING finger (显示 PCGF1 抗体) domain of MDM2 (显示 MDM2 抗体) that is required for homo/hetero-dimerization and for E2 ligase interaction.

  4. Truncating Mutations of MAGEL2, a Gene within the Prader-Willi Locus, Are Responsible for Severe Arthrogryposis.

  5. Consistent with increased cell death, the induced loss of MAGEA2 expression correlated with increased caspase 3 (显示 CASP3 抗体)/7 activity, BCL2 (显示 BCL2 抗体)/BAX (显示 BAX 抗体) ratio and TUNEL signal.

  6. MAGEA2 has a critical role in the development of tamoxifen-resistant breast cancer

  7. MAGEL2 is a new gene causing complex autism spectrum disorder and MAGEL2 loss of function can contribute to several aspects of the Prader-Willi syndrome phenotype.

  8. These findings provide a cellular and molecular function for MAGE-L2-TRIM27 (显示 RFP 抗体) in retrograde transport, including an unappreciated role of K63-linked ubiquitination and identification of an activating signal of the WASH regulatory complex.

  9. MageA2 interferes with p53 (显示 TP53 抗体) acetylation at PML (显示 PML 抗体)-nuclear bodies (NBs (显示 NBN 抗体)) and with PMLIV-dependent activation of p53 (显示 TP53 抗体).

  10. Report MAGEA1 (显示 MAGEA1 抗体)-A6 expression in sputum suggests presence of lung cancer cells or precancerous cells.

Pig (Porcine) MAGE-Like 2 (MAGEL2) interaction partners

  1. Moreover, -712C>G and -708T>C had significant effects on MAGEL2 transcription and placental efficiency

  2. Imprinting analysis showed that NDN (显示 NDN 抗体) and MAGEL2 are paternally expressed in all tissues of pig where the genes were expressed as in human and mouse.

Mouse (Murine) MAGE-Like 2 (MAGEL2) interaction partners

  1. these findings suggest that a loss of Magel2 leads to the disruption of hypothalamic feeding circuits, an effect that appears to be independent of the neurodevelopmental effects of leptin (显示 LEP 抗体) and ghrelin (显示 GHRL 抗体) and likely involves a direct neurotrophic effect of Magel2.

  2. Normal leptin (显示 LEP 抗体) responses were found in Magel2-null mice up to 4 weeks of age, but the proportion of leptin (显示 LEP 抗体)-responsive POMC (显示 POMC 抗体) neurons was reduced in 6-week-old Magel2-null mice.

  3. Magel2 inactivation induces a deficit in social recognition and social interaction and a reduced learning ability in adult male mice.

  4. This neural defect, together with increased fat mass, blunted circadian rhythm, and growth hormone (显示 GH1 PLURAL_@26348@) response pathway defects that are also linked to loss of MAGEL2, could contribute to the hyperphagia and obesity that are hallmarks of this disorder.

  5. This study demonstrated that Magel2-null mice have abnormalities of hypothalamic endocrine axes that recapitulate phenotypes in Prader-Willi syndrome.

  6. Magel2-deficient mouse with 50% neonatal mortality had an altered onset of suckling activity and subsequent impaired feeding.

  7. Magel2 gene is imprinted, with preferential expression from the paternal allele in mouse and human.

  8. role of the circadian rhythm output gene Magel2 in brain structure and behavior

  9. necdin (显示 NDN 抗体) and MAGE-G1 (显示 NDNL2 抗体) target both E2F1 (显示 E2F1 抗体) and p75 (显示 NGFR 抗体) to regulate cell viability during brain development.

  10. Inactivation of the mouse Magel2 gene results in growth abnormalities similar to Prader-Willi syndrome

MAGE-Like 2 (MAGEL2) 抗原简介


This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. This gene has two identical copies at different loci. Alternatively spliced transcript variants encoding the same protein have been identified for this gene.

Gene names and symbols associated with anti-MAGE-Like 2 (MAGEL2) 抗体

  • MAGE-like 2 (MAGEL2) 抗体
  • MAGE-like protein 2 (LOC100343334) 抗体
  • MAGE-like 2 (Magel2) 抗体
  • melanoma antigen family A, 2 (MAGEA2) 抗体
  • melanoma antigen, family L, 2 (Magel2) 抗体
  • CT1.2 抗体
  • Mage-l2 抗体
  • MAGE2 抗体
  • MAGEA2A 抗体
  • MAGEL2 抗体
  • NDNL1 抗体
  • nM15 抗体
  • ns7 抗体

Protein level used designations for anti-MAGE-Like 2 (MAGEL2) 抗体

MAGE-like 2 , MAGE-like protein 2 , necdin-like protein 1 , protein nM15 , melanoma antigen-like gene 2 , melanoma antigen, family L, 2 , MAGE-2 antigen , cancer/testis antigen 1.2 , cancer/testis antigen family 1, member 2 , melanoma antigen 2 , melanoma-associated antigen 2 , necdin-like 1 , protein nS7

719760 Macaca mulatta
100343334 Oryctolagus cuniculus
54551 Homo sapiens
100154924 Sus scrofa
538665 Bos taurus
679875 Rattus norvegicus
4101 Homo sapiens
27385 Mus musculus
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