Izumo Sperm-Egg Fusion 1 (IZUMO1) ELISA试剂盒

The sperm-specific protein Izumo, named for a Japanese shrine dedicated to marriage, is essential for sperm-egg plasma membrane binding and fusion (Inoue et al., 2005 [PubMed 15759005]).[supplied by OMIM, Mar 2008].. 再加上,我们可以发Izumo Sperm-Egg Fusion 1 抗体 (30)Izumo Sperm-Egg Fusion 1 蛋白 (6)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
IZUMO1 284359 Q8IYV9
IZUMO1 73456 Q9D9J7
IZUMO1 499152 Q6AY06
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适于 Izumo Sperm-Egg Fusion 1 相互作用对的更多 ELISA 试剂盒

Cow (Bovine) Izumo Sperm-Egg Fusion 1 (IZUMO1) interaction partners

  1. These findings indicate that impaired fertilizing ability of bull cryopreserved spermatozoa with damaged acrosomes is related partially to the aberrant translocation of IZUMO1 which may be followed by the loss of intact IZUMO1.

Human Izumo Sperm-Egg Fusion 1 (IZUMO1) interaction partners

  1. crystal structures of human IZUMO1, JUNO and the IZUMO1-JUNO complex, establishing the structural basis for the IZUMO1-JUNO-mediated sperm-oocyte interaction

  2. crystal structures of human IZUMO1 and JUNO in unbound and bound conformations

  3. these findings indicate that human sperm expresses Izumo protein, and the immunoinfertile female sera have circulating isoantibodies against this protein.

  4. human sperm contain Izumo and addition of the antibody against human Izumo left the sperm unable to fuse with zona-free hamste (显示 IGSF11 ELISA试剂盒)r eggs [Izumo]

Mouse (Murine) Izumo Sperm-Egg Fusion 1 (IZUMO1) interaction partners

  1. Mice without the cytoplasmic tail of IZUMO1 showed normal fertility but decreased the amount of protein, indicating that whilst this region is important for the expression level of IZUMO1, it is dispensable for fertilisation in the mouse

  2. Five IZUMO BCE were identified: DLVLDCL177-183, YSFYRV196-201 (named BCE-2), YLT217-219, SMVGPED221-227, and DAGNY228-232. Active immunization with the BCE-2 vaccine sharply decreased the fertility rate in female mice in a safe and reversible manner.

  3. Robust IZUMO1-dependent adhesion of sperm with an oocyte accompanies the dimerization of IZUMO1.

  4. Binding of sperm protein Izumo1 and its egg receptor Juno drives Cd9 (显示 CD9 ELISA试剂盒) accumulation in the intercellular contact area prior to fusion during mammalian fertilization.

  5. identification of folate receptor 4 (Folr4) as the receptor for Izumo1 on the mouse egg.

  6. 'IZUMO1 putative functional fragment (IZUMO1PFF) maintains binding ability on the egg surface of Cd9 (显示 CD9 ELISA试剂盒)(-/-) eggs. IZUMO1PFF is composed of an N-terminal unfolded structure and a C-terminal ellipsoidal helix dimer.

  7. Translocation of IZUMO1 during the fertilization process determined by time lapse imaging.

  8. four phosphopeptide changes came from Izumo1, the sperm-egg fusion protein, in the cytoplasmic segment of the protein. 2D-PAGE confirmed that Izumo1 is post-translationally modified during epididymal transit.

  9. co-localization of TMEM190 with IZUMO1 and complex formation with other sperm proteins.

  10. identified an IZUMO1-interacting protein in sperm, which was identified as testis specific (显示 AIF1 ELISA试剂盒) ACE (显示 ACE ELISA试剂盒) homologue ACE3.

Izumo Sperm-Egg Fusion 1 (IZUMO1) 抗原简介

Antigen Summary

The sperm-specific protein Izumo, named for a Japanese shrine dedicated to marriage, is essential for sperm-egg plasma membrane binding and fusion (Inoue et al., 2005

Gene names and symbols associated with IZUMO1

  • izumo sperm-egg fusion 1 (IZUMO1) 抗体
  • Ras interacting protein 1 (RASIP1) 抗体
  • izumo sperm-egg fusion 1 (Izumo1) 抗体
  • 1700058F15Rik 抗体
  • Izumo 抗体

Protein level used designations for IZUMO1

izumo sperm-egg fusion 1 , sperm-egg fusion 1-like , izumo sperm-egg fusion protein 1 , sperm-specific protein Izumo , sperm-egg fusion 1 , izumo sperm-egg fusion protein 1-like , OBF , oocyte binding/fusion factor , sperm-specific protein izumo

GENE ID SPECIES
618057 Bos taurus
718234 Macaca mulatta
747578 Pan troglodytes
100302705 Ovis aries
100358660 Oryctolagus cuniculus
100446925 Pongo abelii
100590428 Nomascus leucogenys
284359 Homo sapiens
73456 Mus musculus
499152 Rattus norvegicus
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