HECT, UBA and WWE Domain Containing 1, E3 Ubiquitin Protein Ligase (HUWE1) ELISA试剂盒

HUWE1 encodes a member of the HECT E3 ubiquitin ligase family. 再加上,我们可以发HUWE1 抗体 (69)HUWE1 蛋白 (2)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
HUWE1 10075 Q7Z6Z7
HUWE1 59026 Q7TMY8
HUWE1 501546  

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产品编号 适用 灵敏度 范围 图像 规格 供应商 交付 价格 详细
小鼠 11 pg/mL 43.75-2800 pg/mL Typical standard curve 96 Tests Log in to see 9至12个工作日
¥3,994.38
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0.1 ng/mL 1.0-25 ng/mL   96 Tests Log in to see 9至12个工作日
¥3,411.38
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大鼠 0.1 ng/mL 1.0-25 ng/mL   96 Tests Log in to see 9至12个工作日
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0.1 ng/mL 1.0-25 ng/mL   96 Tests Log in to see 9至12个工作日
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小鼠 0.1 ng/mL 1.0-25 ng/mL   96 Tests Log in to see 9至12个工作日
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0.067 ng/mL 0.156-10 ng/mL   96 Tests Log in to see 24至29个工作日
¥6,140.16
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绵羊
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小鼠
0.312-20 ng/mL   96 Tests Log in to see 24至29个工作日
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大鼠
0.78-50 ng/mL   96 Tests Log in to see 24至29个工作日
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山羊
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适于 HUWE1 相互作用对的更多 ELISA 试剂盒

Mouse (Murine) HECT, UBA and WWE Domain Containing 1, E3 Ubiquitin Protein Ligase (HUWE1) interaction partners

  1. Mule also regulates protein levels of the receptor tyrosine kinase (显示 ERBB3 ELISA试剂盒) EphB3 (显示 EPHB3 ELISA试剂盒) by targeting it for proteasomal and lysosomal degradation.

  2. this study shows that the E3-ubiquitin ligase Huwe1 (HECT, UBA, and WWE domain-containing 1) is required for proliferating stem cells of the adult mouse hippocampus to return to quiescence.

  3. TNF (显示 TNF ELISA试剂盒) activates Mule by inducing the dissociation of Mule from its inhibitor ARF. Inhibition of Mule phosphorylation by silencing Syk (显示 SYK ELISA试剂盒) prevents this, thereby inhibiting Mule E3 ligase activity and TNF (显示 TNF ELISA试剂盒)-induced JNK (显示 MAPK8 ELISA试剂盒) activation and cell death.

  4. expression level of miR (显示 MLXIP ELISA试剂盒)-98, which can regulate Caspase-3 (显示 CASP3 ELISA试剂盒), was significantly decreased. Huwe1, the host gene of miR (显示 MLXIP ELISA试剂盒)-98, was positively associated with miR (显示 MLXIP ELISA试剂盒)-98 expression after Silica NP exposure

  5. Thus, modulating the levels of both Huwe1 and USP10 (显示 USP10 ELISA试剂盒) appears to fine-tune the requisite degradation of TBP (显示 TBP ELISA试剂盒) during myogenesis.

  6. Results show that ARF-BP1 was expressed at high levels in B-cell lymphoma cell lines and by regulating MYC and p53 transcriptional activity, ARF-BP1 is a critical determinant of the proliferation of B cell lymphomas.

  7. The dynamic balance between MYC and p53 required for normal B cell maturation and function is finely tuned and critically dependent on the activities of ARF-BP1.

  8. data demonstrate in vivo that Mule suppresses Ras-mediated tumorigenesis by preventing an accumulation of c-Myc (显示 MYC ELISA试剂盒)/Miz1 (显示 PIAS2 ELISA试剂盒) complexes that mediates p21 and p15 (显示 CDKN2B ELISA试剂盒) down-regulation

  9. an important role of ARF-BP1 in maintaining beta-cell homeostasis in aging mice and reveal that the stability of p53 is critically regulated by ARF-BP1 in vivo.

  10. Mule regulates the ATM (显示 ATM ELISA试剂盒)-p53 (显示 TP53 ELISA试剂盒) axis to maintain B cell homeostasis under both steady-state and stress conditions.

Human HECT, UBA and WWE Domain Containing 1, E3 Ubiquitin Protein Ligase (HUWE1) interaction partners

  1. HUWE1 is essential for genomic stability, by promoting replication of damaged DNA We show that HUWE1-knockout cells are unable to mitigate replication stress, resulting in replication defects and DNA breakage.

  2. N-myc expression was upregulated in response to stress or following loss of Huwe1, which led to increased proliferation and stem-cell exhaustion.

  3. The interaction with Huwe1 and polyubiquitylation were blocked by disruption of casein kinase 1 (CK1 (显示 CSNK1A1 ELISA试剂盒)) activity, and mass spectrometry and mutational analysis identified serine 334 as an important phosphorylation site for Atoh1 (显示 ATOH1 ELISA试剂盒) ubiquitylation and subsequent degradation.

  4. Elevated HECTH9 protein expression is associated with pathogenesis of hepatocellular carcinoma.

  5. Mechanistic investigation revealed that HUWE1 can regulate p53 protein level through its stabilization. HUWE1 functions as a tumour suppressor in thyroid cancer progression, which may represent a novel therapeutic target for prevention or intervention of thyroid cancer.

  6. We identified a HUWE1 mutation in an affected male with Juberg-Marsidi and Brooks syndromes from the original family reported by Juberg and Marsidi; it is evident the syndrome does not result from a mutation in ATRX as reported in the literature. Additionally, the data indicated that Juberg-Marsidi syndrome and Brooks syndromes are allelic having the same HUWE1 mutation.

  7. Results reveal a pathway controlled by ATM, SIRT6, and SNF2H to block HUWE1, which stabilizes H2AX and induces its incorporation into chromatin only when cells are damaged.

  8. miR-542-5p plays a critical role in the proliferation of osteosarcoma and targets HUWE1.

  9. TNF (显示 TNF ELISA试剂盒) activates Mule by inducing the dissociation of Mule from its inhibitor ARF. Inhibition of Mule phosphorylation by silencing Syk (显示 SYK ELISA试剂盒) prevents this, thereby inhibiting Mule E3 ligase activity and TNF (显示 TNF ELISA试剂盒)-induced JNK (显示 MAPK8 ELISA试剂盒) activation and cell death.

  10. HUWE1 and NEDD4-1 (显示 NEDD4 ELISA试剂盒) are two E3 ligases that are fundamental enzymes in the post-translational regulation of ABCG1 (显示 ABCG1 ELISA试剂盒) and ABCG4 (显示 ABCG4 ELISA试剂盒) protein levels and cellular cholesterol export activity

HUWE1 抗原简介

Antigen Summary

This gene encodes a member of the HECT E3 ubiquitin ligase family. The HECT domain lies in the C-terminus and contains the active-site cysteine which forms an intermediate ubiquitin-thioester bond. E3 family members are divided into three subfamilies based on their protein-protein interaction domains\; this gene encodes a member of the SI(ngle)-HECT E3 subfamily. In lung, breast, and colorectal carcinomas, this gene is highly expressed. Mutations in this gene has been found in 3 unrelated families with X-linked syndromic mental retardation, Turner type.

Gene names and symbols associated with HUWE1

  • HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase (HUWE1) 抗体
  • HECT, UBA and WWE domain containing 1 (Huwe1) 抗体
  • HECT, UBA and WWE domain containing 1 (HUWE1) 抗体
  • HECT, UBA and WWE domain containing 1 (huwe1) 抗体
  • HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase (Huwe1) 抗体
  • 5430439H10Rik 抗体
  • arf-bp1 抗体
  • AU041296 抗体
  • C80292 抗体
  • C430014N20Rik 抗体
  • Gm1718 抗体
  • hecth9 抗体
  • hspc272 抗体
  • Huwe1 抗体
  • ib772 抗体
  • lasu1 抗体
  • mule 抗体
  • si:dkey-242a8.2 抗体
  • URE-B1 抗体
  • ureb1 抗体

Protein level used designations for HUWE1

ARF-binding protein 1 , BJ-HCC-24 tumor antigen , E3 ubiquitin-protein ligase HUWE1 , HECT domain protein LASU1 , Mcl-1 ubiquitin ligase E3 , URE-binding protein 1 , homologous to E6AP carboxyl terminus homologous protein 9 , large structure of UREB1 , upstream regulatory element-binding protein 1 , E3Histone , HECT, UBA and WWE domain-containing protein 1 , Mcl-1 ubiquitin ligase , URE-B1 , upstream regulatory element binding protein 1 , HECT, UBA and WWE domain containing 1 , rp3-339a18.4 , e3 ubiquitin-protein ligase HUWE1-like

GENE ID SPECIES
10075 Homo sapiens
59026 Mus musculus
465650 Pan troglodytes
480931 Canis lupus familiaris
511826 Bos taurus
559439 Danio rerio
700136 Macaca mulatta
100060375 Equus caballus
100123214 Nasonia vitripennis
100126217 Xenopus (Silurana) tropicalis
100380641 Salmo salar
100483129 Ailuropoda melanoleuca
100563451 Anolis carolinensis
501546 Rattus norvegicus
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