Endogenous Retrovirus Group W, Member 1 蛋白 (ERVW-1)

Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. 再加上,我们可以发ERVW-1 抗体 (46)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
ERVW-1 30816 Q9UQF0
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Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
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小麦胚 GST tag 10 μg Log in to see 11至12个工作日
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ERVW-1 蛋白 by Origin and Source

Origin 在表达 标记
Human ,
, ,

引用最多的ERVW-1 蛋白

  1. Human ERVW-1 Protein expressed in Wheat germ - ABIN1353105 : Holder, Tower, Forbes, Mulla, Aplin, Abrahams: Immune cell activation by trophoblast-derived microvesicles is mediated by syncytin 1. in Immunology 2012 (PubMed)

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Human Endogenous Retrovirus Group W, Member 1 (ERVW-1) interaction partners

  1. CD47 (显示 CD47 蛋白) seems to mediate fusion mostly through broad contact surfaces between the partners' cell membrane while syncytin-1 mediate fusion through phagocytic-cup like structure.

  2. ERVWE1, ERVFRDE1 and ERV3 (显示 ERV3-1 蛋白) transcription was down-regulated in hydatidiform moles and gestational trophoblastic neoplasia.

  3. Study found no associations between embroynal ERVW-1 polymorphisms and preeclampsia.

  4. Identification of the two CpG dinucleotides around transcription start site as key epigenetic elements has provided valuable information for further studies on the epigenetic regulation of syncytin-1 in pancreatic cancer cells

  5. Syncytin-1 and ASCT-2 (显示 SLC1A5 蛋白) is localized at the acrosomal region and equatorial segment of the spermatozoa.

  6. The effect of ETS1 (显示 ETS1 蛋白) on syncytialization of trophoblasts likely results, at least in part, from inhibition of syncytin expression.

  7. These results indicated that aberrant hypermethylation is involved in downregulation of syncytin-1, and epigenetic alterations may play a significant role in the development of preeclampsia

  8. Exosomes from cultured primary villous cytotrophoblasts and sera of pregnant women have syncytin-1 on their surfaces. It acts on cellular binding and uptake of exosomes.

  9. Increased trophoblast apoptosis and altered expression levels of syncytin-1, calpain 1 (显示 CAPN1 蛋白), and AIF (显示 AIFM1 蛋白) is observed in preeclamptic placentas.

  10. Syncytin-1 overexpression may be an indicator of urothelial cell carcinoma risk.

蛋白简介ERVW-1

蛋白简介

Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on chromosome 7 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product is expressed in the placental syncytiotrophoblast and is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the placenta. The protein has the characteristics of a typical retroviral envelope protein, including a furin cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. Alternatively spliced transcript variants encoding the same protein have been found for this gene.

Gene names and symbols associated with ERVW-1

  • endogenous retrovirus group W member 1, envelope (ERVW-1)
  • ENV 蛋白
  • ENVW 蛋白
  • ERVWE1 蛋白
  • HERV-7q 蛋白
  • HERV-W-ENV 蛋白
  • HERV7Q 蛋白
  • HERVW 蛋白
  • HERVWENV 蛋白

Protein level used designations for ERVW-1

HERV-7q envelope protein , HERV-W Env glycoprotein , HERV-W envelope protein , HERV-W_7q21.2 provirus ancestral Env polyprotein , HERV-W{7q21.1} provirus ancestral Env polyprotein , HERV-tryptophan envelope protein , endogenous retroviral family W, env(C7), member 1 , endogenous retrovirus group W member 1 , env-W , envelope glycoprotein , envelope polyprotein gPr73 , envelope protein , enverin , human endogenous retrovirus W envC7-1 envelope protein , syncytin A , syncytin-1

GENE ID SPECIES
30816 Homo sapiens
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