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The protein encoded by CCR4 belongs to the G-protein-coupled receptor family . 再加上，我们可以发CCR4 抗体 (231) 和 CCR4 蛋白 (4)和数多这个蛋白质的别的产品。
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A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer
CCR4 is critically involved in regional lymph node dendritic cell-Th17 cell interactions that are necessary for Th17 cell-mediated induction of antitumor CD8 (显示 CD8A ELISA试剂盒)+ effector T cells in mice bearing B16 melanoma.
CCR4 is involved in immunosuppression after severe sepsis and suggest that CCR4+ Regulatory T Cells negatively modulate the short and long-term immune responses.
CCL22 (显示 CCL22 ELISA试剂盒) was localised mainly on the cell surface and or in the cytoplasm. Within sections of omental milky spot micrometastases, CCR4 was recognised on or in gastric cancer cells, constituent cells milky spots, blood cells and blood endothelial cells
CCR4 is involved in regulating negative selection of polyclonal and T cell receptor (TCR) transgenic thymocytes
results show that the IL-4 (显示 IL4 ELISA试剂盒)/CCL22 (显示 CCL22 ELISA试剂盒)/CCR4 axis is involved in the migration of Tregs to osteolytic lesion sites, and attenuates development of lesions by inhibiting inflammatory migration and the production of proinflammatory and osteoclastogenic mediators
These data have uncovered a novel role of core components of the Ccr4-Not complex as regulators of transition from partial to genuine induced pluripotent stem cells.
that effective engagement of CCR4 by CCL17 (显示 CCL17 ELISA试剂盒) involves two distinct binding domains and interaction with both is required for signaling
NF-kappaB (显示 NFKB1 ELISA试剂盒) signaling pathway was involved in the asthmatic change induced by CKLF1, among which CCR4 might play a crucial role
CCR4-expressing Th2cells play a critical role in the pathogenesis of bronchial asthma by producing Th2 cytokines.
Chemokine (显示 CCL1 ELISA试剂盒) receptors CCR3 (显示 CCR3 ELISA试剂盒) and CCR4, and the mucosa specific chemokine (显示 CCL1 ELISA试剂盒) CCL28 have predominant roles in oral wound healing by increasing human gingiva fibroblast proliferation, migration, and the secretion of IL-6 (显示 IL6 ELISA试剂盒) and HGF (显示 HGF ELISA试剂盒) and reducing the secretion of TIMP-1 (显示 TIMP1 ELISA试剂盒).
The percentage of CXCR3 (显示 CXCR3 ELISA试剂盒)(+) CD4 (显示 CD4 ELISA试剂盒)(+) TEM (显示 CYLD ELISA试剂盒) cells negatively correlated with the severity of the cutaneous disease in psoriasis patients. Importantly CLA (显示 SELPLG ELISA试剂盒)(+) CD4 (显示 CD4 ELISA试剂盒)(+) TCM cells expressing CCR6 (显示 CCR6 ELISA试剂盒)(+) or CCR4(+)CXCR3 (显示 CXCR3 ELISA试剂盒)(+) negatively correlated with psoriasis severity suggesting recruitment to the skin compartment.
Case Report: CCR4+ T-cell depletion by mogamulizumab treatment of adult T-cell leukaemia/lymphoma results in CD8 (显示 CD8A ELISA试剂盒)-positive T-cell mediated dermatitis.
CCL22 (显示 CCL22 ELISA试剂盒)-specific antibodies reveal that engagement of two distinct binding domains on CCL22 (显示 CCL22 ELISA试剂盒) is required for CCR4-mediated function.
CCR4 mutation is an important determinant of the clinical course in ATLL cases, and that NS and FS mutations of CCR4 behave differently with respect to ATLL pathophysiology.
Distinctive Treg associated CCR4-CCL22 (显示 CCL22 ELISA试剂盒) expression profile with altered frequency of Th17/Treg cell in the immunopathogenesis of Pemphigus Vulgaris (显示 DSG3 ELISA试剂盒).
Data show that CCR4 was over-expressed in lymph node-negative human gastric cancer tissues and suggest its involvement in promoting tumor invasion probably, through up-regulation of MMP9 (显示 MMP9 ELISA试剂盒).
CCR4 C1014T and CCL22 (显示 CCL22 ELISA试剂盒) C16A genetic variations were neither associated with the risk, nor with the progression of colorectal cancer in Iranian population
Higher percentages of CCR4+ CD4 (显示 CD4 ELISA试剂盒) TEM (显示 CYLD ELISA试剂盒) cells in acute RSV infection were accompanied with higher percentages of CXCR3 (显示 CXCR3 ELISA试剂盒)+ CD8 (显示 CD8A ELISA试剂盒) TEM (显示 CYLD ELISA试剂盒) cells, whereas the development of long-lived memory CXCR3 (显示 CXCR3 ELISA试剂盒)+ CD4 (显示 CD4 ELISA试剂盒) and CD8 (显示 CD8A ELISA试剂盒) TCM cells seems to be compromised
The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis.
chemokine (C-C motif) receptor 4
, C-C chemokine receptor type 4-like
, c-C chemokine receptor type 4-like
, CCR4-NOT transcription complex subunit 6
, carbon catabolite repressor protein 4 homolog
, cytoplasmic deadenylase
, C-C CKR-4
, C-C chemokine receptor type 4
, chemokine (C-C) receptor 4
, CC chemokine receptor 4
, leukocyte-expressed seven-transmembrane-domain receptor
, C-C chemokine receptor 4