Bridging Integrator 1 (BIN1) ELISA试剂盒

BIN1 encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. 再加上,我们可以发BIN1 抗体 (108)BIN1 蛋白 (15)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
BIN1 274 O00499
BIN1 30948 O08539
BIN1 117028 O08839

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适于 BIN1 相互作用对的更多 ELISA 试剂盒

Human Bridging Integrator 1 (BIN1) interaction partners

  1. propose that efforts to define how genetic variants in BIN1 elevate the risk for Alzheimer's disease would behoove to consider BIN1 function in the context of its main expression in mature oligodendrocytes

  2. The results emphasize an additional level of complexity in the regulation of the interaction between BIN1 and Tau dependent on the BIN1 isoforms.

  3. Data (including data from studies using transgenic mice) suggest that the process leading to microparticle release from cardiac myocytes involves recruitment of CHMP4B (显示 CHMP4A ELISA试剂盒) protein to the forming microparticle membrane which also contains cBIN1; plasma cBIN1 is reduced in patients with heart failure as compared to control subjects. (CHMP4B (显示 CHMP4A ELISA试剂盒) = charged multivesicular body protein 4B (显示 CHMP4B ELISA试剂盒); cBIN1 = cardiac bridging integrator 1)

  4. Low Bin1 expression is associated with esophageal squamous cell carcinoma.

  5. the depletion of BIN1 increases cellular BACE1 (显示 BACE ELISA试剂盒) levels through impaired endosomal trafficking and reduces BACE1 (显示 BACE ELISA试剂盒) lysosomal degradation, resulting in increased Ab production. Our findings provide a mechanistic role of BIN1 in the pathogenesis of Alzheimer disease (AD), as a novel genetic regulator of BACE1 (显示 BACE ELISA试剂盒) levels and Ab production

  6. BIN1 protein expression in cerebral cortex was related to disease progression in Alzheimer's Disease patients.

  7. data show that the previously described consensus sequence PXRPXR for amphiphysin SH3 ligands is inaccurate and instead define it as an extended Class II binding motif PXXPXRpXR, where additional positive charges between the two constant arginine residues can give rise to extraordinary high SH3 binding affinity.

  8. findings support a contribution of BIN1 to individual differences in episodic memory performance among Type 2 Diabetes patients.

  9. analysis of a novel deregulated mechanism in chronic myeloid leukemia (显示 BCL11A ELISA试剂盒) patients, indicating BIN1 and RIN1 (显示 RIN1 ELISA试剂盒) as players in the maintenance of the abnormal RTK signaling in this hematological disease

  10. BIN1 is involved with late onset Alzheimer's disease. [review]

Mouse (Murine) Bridging Integrator 1 (BIN1) interaction partners

  1. Data (including data from studies using transgenic mice) suggest that the process leading to microparticle release from cardiac myocytes involves recruitment of CHMP4B (显示 CHMP4B ELISA试剂盒) protein to the forming microparticle membrane which also contains cBIN1; plasma cBIN1 is reduced in patients with heart failure as compared to control subjects. (CHMP4B (显示 CHMP4B ELISA试剂盒) = charged multivesicular body protein 4B (显示 CHMP4B ELISA试剂盒); cBIN1 = cardiac bridging integrator 1)

  2. Bin1 and CD2AP (显示 Cd2ap ELISA试剂盒) keep APP (显示 APP ELISA试剂盒) and BACE1 (显示 BACE ELISA试剂盒) apart in early endosomes by distinct mechanisms in axon and dendrites. Individuals carrying variants of either factor would slowly accumulate Abeta (显示 APP ELISA试剂盒) in neurons increasing the risk for late-onset AD.

  3. the depletion of BIN1 increases cellular BACE1 (显示 BACE ELISA试剂盒) levels through impaired endosomal trafficking and reduces BACE1 (显示 BACE ELISA试剂盒) lysosomal degradation, resulting in increased Ab production. Our findings provide a mechanistic role of BIN1 in the pathogenesis of Alzheimer disease (AD), as a novel genetic regulator of BACE1 (显示 BACE ELISA试剂盒) levels and Ab production

  4. Data demonstrate that EHBP1L1 links Rab8 (显示 RAB8A ELISA试剂盒) and the Bin1-dynamin (显示 DNM1 ELISA试剂盒) complex, which generates membrane curvature and excises the vesicle at the endocytic recycling compartment for apical transport.

  5. Findings show how cardiac deficiency in Bin1 function causes age- and stress-associated heart failure suggesting that Bin1 is a positive modifier of cardiac contractility that helps sustain adult heart function under stress conditions.

  6. Reorganization of BIN1-induced microdomains recruits phosphorylated ryanodine receptors into dyads, increasing calcium signaling.

  7. Bin1 mAb reduced colitis morbidity in mice while unprotected mice were characterized by severe lesions throughout the mucosa, rupture of lymphoid follicle, high-level neutrophil and lymphocyte infiltration into the mucosal areas, loss of surface crypts.

  8. The release of BIN1 from hypo-poly(ADP-ribosyl)ated E2F1 (显示 E2F1 ELISA试剂盒) is a mechanism by which serum starvation promotes E2F1 (显示 E2F1 ELISA试剂盒)-induced apoptosis.

  9. BIN1 interacts with MTM1 (显示 MTM1 ELISA试剂盒) in skeletal muscle.

  10. Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia.

BIN1 抗原简介

Antigen Summary

This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.

Gene names and symbols associated with BIN1

  • bridging integrator 1 (BIN1) 抗体
  • bridging integrator 1 (bin1) 抗体
  • bridging integrator 1 (Bin1) 抗体
  • ALP-1 抗体
  • AMPH2 抗体
  • Amphl 抗体
  • BIN1 抗体
  • BRAMP-2 抗体
  • cb57 抗体
  • MGC53185 抗体
  • MGC76187 抗体
  • SH3P9 抗体
  • zgc:86701 抗体

Protein level used designations for BIN1

bridging integrator 1 , myc box-dependent-interacting protein 1-like , amphiphysin II , amphiphysin-like protein , box dependant MYC interacting protein 1 , box-dependent myc-interacting protein 1 , myc box-dependent-interacting protein 1 , SH3 domain-containing protein 9 , amphiphysin 2 , myc box dependent interacting protein 1 , Amph2 , amphiphysin IIamph2

GENE ID SPECIES
100052213 Equus caballus
380484 Xenopus laevis
394839 Xenopus (Silurana) tropicalis
447863 Danio rerio
735972 Pan troglodytes
100451162 Pongo abelii
100475668 Ailuropoda melanoleuca
100018912 Monodelphis domestica
100544136 Meleagris gallopavo
100599872 Nomascus leucogenys
274 Homo sapiens
30948 Mus musculus
424228 Gallus gallus
100037305 Sus scrofa
117028 Rattus norvegicus
483870 Canis lupus familiaris
614576 Bos taurus
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