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BLNK encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. 再加上，我们可以发B-Cell Linker 抗体 (212) 和 B-Cell Linker 蛋白 (13)和数多这个蛋白质的别的产品。
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The pre-B-cell receptor (pre-BCR (显示 BCR ELISA试剂盒)) signaling molecules BLNK, BTK (显示 BTK ELISA试剂盒) and BANK1 (显示 BANK1 ELISA试剂盒) were positively regulated by the ZFP521 gene, leading to enhancement of the pre-BCR (显示 BCR ELISA试剂盒) signaling pathway.
Authors demonstrate leukemogenicity of PAX5 (显示 PAX5 ELISA试剂盒)-PML (显示 PML ELISA试剂盒) by introducing it into normal mouse pro-B cells; B-cell linker protein (Blnk) is repressed by PAX5 (显示 PAX5 ELISA试剂盒)-PML (显示 PML ELISA试剂盒) in leukemia cells; enforced expression of Blnk increases survival despite introduction of PAX5 (显示 PAX5 ELISA试剂盒)-PML (显示 PML ELISA试剂盒).
B-cell linker protein expression contributes to controlling allergic and autoimmune diseases by mediating IL-10 (显示 IL10 ELISA试剂盒) production in regulatory B cells.
Tumor suppressor BLNK is a target of transcriptional activation by PU.1 and Spi-B (显示 SPIB ELISA试剂盒) in the B cell lineage.
a novel negative feedback regulation of BCR (显示 BCR ELISA试剂盒) signaling by HPK1-mediated phosphorylation, ubiquitination, and subsequent degradation of the activated BLNK
CMTM7 (显示 CMTM7 ELISA试剂盒) functions to link sIgM and BLNK in the plasma membrane.
Live cell imaging and co-immunoprecipitation experiments confirmed that both SLP65 and CIN85 (显示 SH3KBP1 ELISA试剂盒) are both required for the onset and progression phases of B-cell antigen receptor signal transduction.
malignant transformation of Btk (显示 BTK ELISA试剂盒)/Slp65 double-deficient pre-B cells is independent of deregulated V(D)J recombination activity.
Swip-1 (显示 WSB1 ELISA试剂盒) provides a membrane scaffold that is required for the Syk (显示 SYK ELISA试剂盒)-, SLP-65-, and PLCgamma2 (显示 PLCG2 ELISA试剂盒)-dependent BCR (显示 BCR ELISA试剂盒)-induced calcium flux.
malignant transformation of Slp65(-/-) pre-B cells involves disruption of the p19(Arf)-Mdm2-p53 tumor suppressor pathway
vesicular signaling scaffolds are required for B cell activation indicates that vesicles may deliver preassembled signaling cargo to sites of BCR (显示 BCR ELISA试剂盒) activation.
early Ca(2 (显示 CA2 ELISA试剂盒)+) fluxing provides feed-forward signal amplification by promoting anchoring of the PLCgamma2 (显示 PLCG2 ELISA试剂盒) C2 domain to phospho-SLP65.
up-regulation of BLNK is associated with RUNX1 (显示 RUNX1 ELISA试剂盒) mutations in cytogenetically normal acute myeloid leukemia (显示 BCL11A ELISA试剂盒).
16 of the 34 childhood pre-B acute lymphoblastic leukaemia samples that were tested showed a complete loss or drastic reduction of SLP-65 expression
The BLNK protein is present in the majority of mediastinal B cell lymphomas.
In B cells SLP-65 exists in a 180 kDa complex as well as in monomeric form.
V(H) gene rearrangement represents a frequent feature in B-lymphoid malignancy, which can be attributed to SLP65 deficiency in many cases.
Syk (显示 SYK ELISA试剂盒) is required to link phosphorylated SLP-65 to Ca(2 (显示 CA2 ELISA试剂盒)+) mobilization.
Plasmacytoid dendritic cells express a signalosome consisting of Lyn (显示 LYN ELISA试剂盒), Syk (显示 SYK ELISA试剂盒), Btk (显示 BTK ELISA试剂盒), Slp65 (Blnk) and PLCgamma2 (显示 PLCG2 ELISA试剂盒). Triggering CD303 leads to tyrosine phosphorylation of Syk (显示 SYK ELISA试剂盒), Slp65, PLCgamma2 (显示 PLCG2 ELISA试剂盒) & cytoskeletal proteins.
This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene.
, B-cell linker protein
, b-cell linker protein-like
, B-cell adapter containing a SH2 domain protein
, B-cell adapter containing a Src homology 2 domain protein
, cytoplasmic adapter protein
, lymphocyte antigen 57
, src homology 2 domain-containing leukocyte protein of 65 kDa
, B cell adaptor containing SH2 domain
, B cell linker protein
, B-cell activation
, Src homology 2 domain-containing leukocyte protein of 65 kDa
, Src homology [SH2] domain-containing leukocyte protein of 65 kD
, B cell linker protein BLNK
, B-cell adapter SH2 domain-containing protein