anti-Angiotensin I Converting Enzyme 2 (ACE2) 抗体

The protein encoded by ACE2 belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme.

列出全部抗体 基因 基因ID UniProt
 ACE2 ACE2 59272 Q9BYF1
小鼠 ACE2 ACE2 70008 Q8R0I0
大鼠 ACE2 ACE2 302668 Q5EGZ1

更多抗Angiotensin I Converting Enzyme 2的相互作用对抗体

Human Angiotensin I Converting Enzyme 2 (ACE2) interaction partners

  1. Overexpression of ACE2 ameliorates Abeta (显示 APP 抗体)-induced inflammatory response by activating the ACE2/Ang-(1 (显示 ANGPT1 抗体)-7)/Mas (显示 MAS1 抗体) axis in human RPE (显示 RPE 抗体) cells.

  2. Although further studies are required to determine how clusterin (显示 CLU 抗体) suppresses non-specific cellular uptake in phagocytes, our data suggest that clusterin (显示 CLU 抗体) plays a key role in the stealth effect of not only pegylated nanoparticles but also non-pegylated nanoparticles.

  3. The ACE2 G8790A polymorphism in type 2 diabetes mellitus patients was correlated with cerebral stroke, and the A allele might be a risk factor of type 2 diabetes mellitus combined with cerebral stroke.

  4. ollectrin, an ACE2 homolog with no catalytic activity, regulates blood pressure through an NO-dependent mechanism. Large body of experimental data confirmed sustained beneficial effects of ACE2/Ang-(1 (显示 ANGPT1 抗体)-7)/Mas (显示 MAS1 抗体) receptor axis activation on hypertension and vascular injury.

  5. The potential contribution of the ACE2 to cardiovascular disease progression was addressed.

  6. Serum ACE2 activity was significantly lower in acute ischemic stroke as compared to both control and stroke-alert patients, followed by an increase to control levels at three days.

  7. Here, we review the role and effects of ACE2, ACE2 activators, Ang-(1 (显示 ANGPT1 抗体)-7) and synthetic Mas (显示 MAS1 抗体) receptor agonists in the control of inflammation and fibrosis in cardiovascular and renal diseases and as counter-regulators of the ACE (显示 ACE 抗体)-Ang II (显示 AGT 抗体)-AT1 (显示 AGTR1 抗体) axis.

  8. ACE2 overexpression inhibited cell growth.

  9. Downregulation of ACE2/Ang-(1 (显示 ANGPT1 抗体)-7)/Mas (显示 MAS1 抗体) axis stimulates breast cancer metastasis through the activation of store-operated calcium entry and PAK1 (显示 PAK1 抗体)/NF-kappaB (显示 NFKB1 抗体)/Snail1 (显示 SNAI1 抗体) pathways.

  10. The circulating ACE2 and Ang-(1 (显示 ANGPT1 抗体)-7) levels were related to neither rs4646155 nor rs879922 in female or male patients.In conclusion, the rs2106809 polymorphism of the ACE2 gene may be a determinant of the circulating Ang-(1 (显示 ANGPT1 抗体)-7) level in female patients with hypertension, suggesting a genetic association between circulating Ang-(1 (显示 ANGPT1 抗体)-7) levels and ACE2 gene polymorphisms in patients with hypertension.

Mouse (Murine) Angiotensin I Converting Enzyme 2 (ACE2) interaction partners

  1. Altogether, our study demonstrates that HFD feeding increases RAS activity and mediates glycemic dysregulation likely through loss of ACE2 present outside the islets but independently of changes in islet ACE2.

  2. Results suggest that angiotensin converting enzyme 2 may reduce anxiety-like behavior by activating central Mas (显示 MAS1 抗体) receptor that facilitate GABA release onto pyramidal neurons within the basolateral amygdala.

  3. These findings demonstrate that ACE2 plays a critical role in preventing RSV-induced lung injury, and suggest that ACE2 is a promising potential therapeutic target in the management of RSV-induced lung disease.

  4. ACE2 overexpression significantly reduced the myocardial infarction-induced increase in apoptosis, macrophage infiltration, and HMGB1 (显示 HMGB1 抗体) and proinflammatory cytokine expression.

  5. ACE2 regulates vascular function by modulating nitric oxide release.

  6. MAS (显示 MAS1 抗体) receptors mediate vasoprotective and atheroprotective effects of candesartan upon the recovery of vascular ACE2-angiotensin-(1-7)-MAS (显示 MAS1 抗体) axis functionality

  7. ACE2 plays a novel role in heart disease associated with obesity wherein ACE2 negatively regulates obesity-induced epicardial adipose tissue inflammation and cardiac insulin (显示 INS 抗体) resistance.

  8. a Mas (显示 MAS1 抗体) receptor-mediated mechanism may stimulate pancreatic cell development

  9. ACE2 deficiency exacerbates kidney inflammation, oxidative stress and adverse renal injury in the ApoE (显示 APOE 抗体)-mutant mice through modulation of the nephrin (显示 NPHS1 抗体), NOX4 (显示 NOX4 抗体) and TNF-alpha (显示 TNF 抗体)-TNFRSF1A (显示 TNFRSF1A 抗体) signaling.

  10. Hydronephrosis led to an increase of ACE (显示 ACE 抗体) level and a decrease of ACE2 and Mas (显示 MAS1 抗体) receptor in the heart.

Cow (Bovine) Angiotensin I Converting Enzyme 2 (ACE2) interaction partners

  1. The objective of this study was to characterize the profiles of Ang-(1-7), MAS receptor, ACE(2), NEP and PEP during the ovulatory process in cattle.

Rhesus Monkey Angiotensin I Converting Enzyme 2 (ACE2) interaction partners

  1. sporadic non-synonymous substitutions reduced the level of rh-ACE2 protein expression and did not support severe acute respiratory syndrome coronavirus entry effectively

Pig (Porcine) Angiotensin I Converting Enzyme 2 (ACE2) interaction partners

  1. In a pig model of acute pulmonary embolism leading to cardiac arrest, captopril infusion was associated with less mean right ventricular pressure overload after resuscitation, compared with saline infusion. The reduction in systemic and pulmonary vascular resistance associated with captopril may be by inhibiting the ACE (显示 ACE 抗体)-Ang II (显示 AGT 抗体)-AT1R (显示 AGTR1 抗体) axis and activating the ACE2/Ang-(1 (显示 ANGPT1 抗体)-7)/Mas (显示 MAS1 抗体) axis.

  2. This study produced the full-length porcine ACE2 cDNA sequence and found polyunsaturated fatty acids could downregulate the expression of ACE2.

Angiotensin I Converting Enzyme 2 (ACE2) 抗原简介

蛋白简介

The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63.

Gene names and symbols associated with ACE2

  • angiotensin I converting enzyme 2 (ACE2) 抗体
  • angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 (Ace2) 抗体
  • angiotensin I converting enzyme 2 (Ace2) 抗体
  • angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 (ACE2) 抗体
  • angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 (ace2) 抗体
  • 2010305L05Rik 抗体
  • ACEH 抗体
  • zgc:92514 抗体

Protein level used designations for ACE2

ACE-related carboxypeptidase , angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 , angiotensin-converting enzyme 2 , angiotensin-converting enzyme homolog , metalloprotease MPROT15 , peptidyl-dipeptidase A , angiotensin I converting enzyme 2 , anigotensin-converting enzyme-related carboxypeptidase , renal angiotensin-converting enzyme 2

GENE ID SPECIES
59272 Homo sapiens
70008 Mus musculus
302668 Rattus norvegicus
418623 Gallus gallus
480847 Canis lupus familiaris
492331 Danio rerio
509235 Bos taurus
554349 Felis catus
712790 Macaca mulatta
100144303 Sus scrofa
100171441 Pongo abelii
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