ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 蛋白 (ABCB1)

The membrane-associated protein encoded by ABCB1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. 再加上,我们可以发ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 抗体 (280)ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 试剂盒 (21)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
ABCB1 5243 P08183
大鼠 ABCB1 ABCB1 170913  
小鼠 ABCB1 ABCB1 18669 P06795
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大肠杆菌(E. Coli) His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30至35个工作日
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Insect Cells rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 70至75个工作日
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小麦胚 GST tag 10 μg Log in to see 11至12个工作日
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Insect cells (Sf9) His tag Validation with Western Blot 20 μg Log in to see 10至12个工作日
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酵母菌 REACT_Entamoeba histolytica His tag   500 μg Log in to see 60至71个工作日
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ABCB1 蛋白 by Origin and Source

Origin 在表达 标记
Human , , ,
, , ,

引用最多的ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 蛋白

  1. Human ABCB1 Protein expressed in Wheat germ - ABIN1305435 : Kamiie, Ohtsuki, Iwase, Ohmine, Katsukura, Yanai, Sekine, Uchida, Ito, Terasaki: Quantitative atlas of membrane transporter proteins: development and application of a highly sensitive simultaneous LC/MS/MS method combined with novel in-silico peptide selection criteria. in Pharmaceutical research 2008 (PubMed)

更多ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1)互动伙伴

Cow (Bovine) ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) interaction partners

  1. P-gp (显示 ABCB4 蛋白), Bcrp and Mrp1 (显示 ABCC1 蛋白) are functionally expressed in bovine/rat co-culture model and model is suitable for investigations of small molecule transport.

  2. This study has, for the first time, confirmed the expression of ABCB1 in epithelial cells of the bovine rumen.

  3. Bovine blastocysts stimulated by the combined treatment with forskolin, rifampicin, and interferon-alpha to express high levels of ATP-binding cassette subfamily B member 1 displayed better freezing resistance

  4. ABCB1 is expressed in bovine oocytes and embryos.

Human ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) interaction partners

  1. we review the emerging role of molecular dynamics simulation techniques in our understanding of the membrane-embedded conformation of P-gp (显示 ABCB4 蛋白)--{REVIEW}

  2. Studied ABCB1 protein expression immunohistochemically in twelve human post-mortem brain regions known to play a role in schizophrenia, in 13 patients with schizophrenia and nine controls; found a significantly reduced density of ABCB1-expressing neurons in the left habenula.

  3. Using an integrated pathway-based approach, we identified polymorphisms in ABCC6 (显示 ABCC6 蛋白), ABCB1 and CYP2C8 (显示 CYP2C8 蛋白) associated with overall survival. These associations were replicated in a large independent cohort, highlighting the importance of pharmacokinetic genes as prognostic markers in Ewing sarcoma

  4. The authors found that transient TUBB3 (显示 TUBB3 蛋白) activation, through ABCB1, in response to the stimulation of FOXO3a (显示 FOXO3 蛋白) expression, significantly contributes to the cross-resistance of the paclitaxel-resistant cell population and consequently limits the efficacy of both agents where cancer cells have developed multiple resistance.

  5. MDR1 and CYP3A5 (显示 CYP3A5 蛋白) genetic polymorphisms significantly influence plasma trough levels and therapeutic response of imatinib in patients with chronic myeloid leukemia (显示 BCL11A 蛋白). Patients with GG genotype for CYP3A5 (显示 CYP3A5 蛋白)-A6986G (P=0.016) and TT genotype for MDR1-C3435T (P=0.013) polymorphisms had significantly higher trough levels of imatinib.

  6. Rescue experiments confirmed the combined role of LUCAT1, miR (显示 MLXIP 蛋白)-200c and ABCB1 on osteosarcoma proliferation, invasion and methotrexate resistance. Overall, results indicate the vital role of LUCAT1 in the methotrexate resistance regulation through miR (显示 MLXIP 蛋白)-200c/ABCB1 pathway, providing a novel insight and treatment strategy for osteosarcoma drug resistance.

  7. Mdr1 enforces T Cell homeostasis in the presence of intestinal bile acids.

  8. Data show that co-treated with vincristine and XL019, a inhibitor of JAK2 and P-glycoprotein (P-gp), up-regulated expression of p21 and phosphorylated H2A histone family, member X (pH2AX).

  9. Tangeretin could sensitize ABCB1-overexpressing cancer cells to chemotherapeutical agents by directly inhibiting ABCB1 transporter function.

  10. over-functional P-gp (显示 ABCB4 蛋白) might play an important role in the pathogenesis of ITP (显示 ITPA 蛋白) and induce GCs (显示 GCLC 蛋白) resistance in nonresponsive ITP (显示 ITPA 蛋白) patients. The blockage of P-gp (显示 ABCB4 蛋白) could be a promising therapeutic approach for GCs (显示 GCLC 蛋白)-resistant patients with ITP (显示 ITPA 蛋白).

Mouse (Murine) ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) interaction partners

  1. conclusion, MDR1 (显示 ABCB4 蛋白) and BCRP are expressed on apical membranes of the rodent placental SynT (显示 STX1A 蛋白)-II layer.

  2. Mdr1 (显示 ABCB4 蛋白) enforces T Cell homeostasis in the presence of intestinal bile acids.

  3. Loss of ABCB1 expression is associated with neonatal hyperbilirubinemia.

  4. the high-affinity site of P-glycoprotein is inaccessible because of either a conformational change or binding of detergent at the binding site in a detergent micelle environment; ligands bind to a low-affinity site, resulting in altered modulation of P-gp ATPase activity

  5. Data suggest that ATP binding to Abcb1b/P-glycoprotein (Pgp) in liposomes exhibits cooperativity with verapamil (a cardiovascular/antiarrhythmia drug); cooperativity between verapamil and a nonhydrolyzable ATP analog (AMPPNP) leads to distinct global conformational changes in Abcb1b/Pgp.

  6. Chrysosplenetin inhibited P-gp (显示 ABCB4 蛋白) activity and reverse the up-regulated P-gp (显示 ABCB4 蛋白) and MDR1 (显示 ABCB4 蛋白) levels induced by artemisinin.

  7. Tamsulosin and tolterodine with P-gp (显示 ABCB4 蛋白) gene expression and activity in an enantiomer-specific way.

  8. Pgp-coupled ATPase activity kinetics measured with a range of verapamil and digoxin concentrations fit well to a DDI model encompassing non-competitive and competitive inhibition of digoxin by verapamil.

  9. Data show that human transgenic mutant huntingtin (显示 HTT 蛋白) (mHtt) aggregation might be regulated by multidrug resistance protein 1 (MDR1 (显示 ABCB4 蛋白)) which suggests that MDR1 (显示 ABCB4 蛋白) might be a potential therapeutic target for Huntington's disease.

  10. In vitro and in vivo downregulation of the ATP binding cassette transporter (显示 ABCC3 蛋白) B1 by the HMG-CoA reductase (显示 HMGCR 蛋白) inhibitor simvastatin

蛋白简介ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1)

蛋白简介

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.

Gene names and symbols associated with ABCB1

  • ATP binding cassette subfamily B member 1 (ABCB1)
  • ATP binding cassette subfamily B member 1 L homeolog (abcb1.L)
  • ATP binding cassette subfamily B member 1A (Abcb1a)
  • ATP binding cassette subfamily B member 1 (Abcb1)
  • ATP-binding cassette, sub-family B (MDR/TAP), member 1B (Abcb1b)
  • ATP-binding cassette, subfamily B (MDR/TAP), member 1B (Abcb1b)
  • malic enzyme complex, mitochondrial (Mod2)
  • ABC20 蛋白
  • ABCB1 蛋白
  • Cd243 蛋白
  • CLCS 蛋白
  • GP170 蛋白
  • Mdr 蛋白
  • Mdr-1 蛋白
  • Mdr1 蛋白
  • Mdr1a 蛋白
  • Mdr1b 蛋白
  • Mod-2 蛋白
  • Mod-2r 蛋白
  • Mod-2s 蛋白
  • Mod2-r 蛋白
  • Mod2-s 蛋白
  • p-gp 蛋白
  • PGP1 蛋白
  • Pgy-1 蛋白
  • Pgy1 蛋白
  • xemdr 蛋白

Protein level used designations for ABCB1

bovine P-glycoprotein , multidrug resistance protein 1 , multidrug resistance protein , ATP-binding cassette sub-family B member 1 , P-glycoprotein 1 , colchicin sensitivity , doxorubicin resistance , ATP-binding cassette, subfamily B, member 1 , P-glycoprotein , multidrug resistance p-glycoprotein , ATP-binding cassette, sub-family B (MDR/TAP), member 1 , ATP-binding cassette, subfamily B (MDR/TAP), member 1A , multiple drug resistant 1a , P glycoprotein 1 , multidrug resistance protein 1B , ATP-binding cassette sub-family B (MDR/TAP) member 1 (P-glycoprotein/multidrug resistance 1) , ATP-binding cassette, sub-family B (MDR/TAP), member 1 (P-glycoprotein/multidrug resistance 1) , ATP-binding cassette, sub-family B (MDR/TAP), member 1B , ATP-binding cassette, subfamily B, member 1B , P-glycoprotein/multidrug resistance 1 , malic enzyme complex, mitochondrial , malic enzyme, mitochondrial regulatory , malic enzyme, mitochondrial structural

GENE ID SPECIES
281585 Bos taurus
397812 Xenopus laevis
463516 Pan troglodytes
5243 Homo sapiens
403879 Canis lupus familiaris
170913 Rattus norvegicus
100682536 Cricetulus griseus
18669 Mus musculus
24646 Rattus norvegicus
110357 Mus musculus
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