Transcription factor that can both act as an activator or a repressor depending on the context. Involved in BMP signaling and in the regulation of the immature compartment of the hematopoietic system. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved specification of B-cell lineage\; this interaction preventing EBF1 to bind DNA and activate target genes.
Spina, Filocamo, Iaccino, Scicchitano, Lupia, Chiarella, Mega, Bernaudo, Pelaggi, Mesuraca, Pazzaglia, Semenkow, Bar, Kool, Pfister, Bond, Eberhart, Steinkühler, Morrone: "Critical role of zinc finger protein 521 in the control of growth, clonogenicity and tumorigenic potential of medulloblastoma cells." in: Oncotarget, Vol. 4, Issue 8, pp. 1280-92, (2013) (PubMed).
Aliases for ZNF521 抗体
zinc finger protein 521 (Zfp521) 抗体 zinc finger protein 521 (ZNF521) 抗体 zinc finger protein 521 S homeolog (znf521.S) 抗体 B930086A16Rik 抗体 EHZF 抗体 Evi3 抗体 Znf521 抗体