This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development, and have been associated with X-linked visceral heterotaxy and holoprosencephaly type 5. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 1, a related family member on chromosome 3. Heterozygous deletion of these linked genes is involved in Dandy-Walker malformation, which is a congenital cerebellar malformation. Multiple transcript variants have been identified for this gene. [provided by RefSeq, Dec 2009].
Grinberg, Northrup, Ardinger, Prasad, Dobyns, Millen: "Heterozygous deletion of the linked genes ZIC1 and ZIC4 is involved in Dandy-Walker malformation." in: Nature genetics, Vol. 36, Issue 10, pp. 1053-5, (2004) (PubMed).
Ishiguro, Inoue, Mikoshiba, Aruga: "Molecular properties of Zic4 and Zic5 proteins: functional diversity within Zic family." in: Biochemical and biophysical research communications, Vol. 324, Issue 1, pp. 302-7, (2004) (PubMed).
Aliases for ZIC4 抗体
Zic family member 4 (ZIC4) 抗体 Zic family member 4 (Zic4) 抗体 Zic family member 4 L homeolog (zic4.L) 抗体 zinc finger protein of the cerebellum 4 (Zic4) 抗体 XlZic4 抗体