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ZIC2 产品

(ZIC2)

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This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This protein functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. Mutations in this gene cause holoprosencephaly type 5. Holoprosencephaly is the most common structural anomaly of the human brain. A polyhistidine tract polymorphism in this gene may be associated with increased risk of neural tube defects. This gene is closely linked to a gene encoding zinc finger protein of the cerebellum 5, a related family member on chromosome 13. [provided by RefSeq, Jul 2008].

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Featured ZIC2 Categories

ZIC2 抗体

High quality antibodies with extensive validation data.

ZIC2 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended ZIC2 抗体

Product
Reactivity
Application
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Cat. No.
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Reactivity Guinea Pig, Human, Mouse, Rat
Application WB, IHC
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  • (3)
Cat. No. ABIN2776475
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Monkey, Pig
Application WB, IHC, IHC (p)
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  • (2)
Cat. No. ABIN6736299
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application ELISA, IHC
Validations
  • (1)
Cat. No. ABIN7249346
Quantity 200 μL
Datasheet Datasheet

Recommended ZIC2 蛋白

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Reactivity Human
Source Insect Cells
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Cat. No. ABIN3096438
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
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Cat. No. ABIN2735883
Quantity 20 μg
Datasheet Datasheet

Latest Publications for our ZIC2 Products

Toth, Schiffmann, Hube-Magg, Büscheck, Höflmayer, Weidemann, Lebok, Fraune, Minner, Schlomm, Sauter, Plass, Assenov, Simon, Meiners, Gerhäuser: "Random forest-based modelling to detect biomarkers for prostate cancer progression." in: Clinical epigenetics, Vol. 11, Issue 1, pp. 148, (2020) (PubMed).

Inaguma, Ito, Riku, Ikeda, Kasai: "Addiction of pancreatic cancer cells to zinc-finger transcription factor ZIC2." in: Oncotarget, Vol. 6, Issue 29, pp. 28257-68, (2015) (PubMed).

Zhu, Wang, He, Huang, Du, Zhang, Yan, Xia, Ye, Wang, Hao, Wu, Fan: "ZIC2-dependent OCT4 activation drives self-renewal of human liver cancer stem cells." in: The Journal of clinical investigation, Vol. 125, Issue 10, pp. 3795-808, (2015) (PubMed).

Sakuma, Kasamatsu, Yamatoji, Yamano, Fushimi, Iyoda, Ogoshi, Shinozuka, Ogawara, Shiiba, Tanzawa, Uzawa: "Expression status of Zic family member 2 as a prognostic marker for oral squamous cell carcinoma." in: Journal of cancer research and clinical oncology, Vol. 136, Issue 4, pp. 553-9, (2010) (PubMed).

McCampbell, Truong, Broom, Allchorne, Gable, Cutler, Mattson, Woolf, Frosch, Harmon, Dunn, Brown: "Mutant SPTLC1 dominantly inhibits serine palmitoyltransferase activity in vivo and confers an age-dependent neuropathy." in: Human molecular genetics, Vol. 14, Issue 22, pp. 3507-21, (2005) (PubMed).

Dubourg, Lazaro, Pasquier, Bendavid, Blayau, Le Duff, Durou, Odent, David: "Molecular screening of SHH, ZIC2, SIX3, and TGIF genes in patients with features of holoprosencephaly spectrum: Mutation review and genotype-phenotype correlations." in: Human mutation, Vol. 24, Issue 1, pp. 43-51, (2004) (PubMed).

Herrera, Brown, Aruga, Rachel, Dolen, Mikoshiba, Brown, Mason: "Zic2 patterns binocular vision by specifying the uncrossed retinal projection." in: Cell, Vol. 114, Issue 5, pp. 545-57, (2003) (PubMed).

Brown, Hodge, Johnson, Guy, Nye, Brown: "Possible association of NTDs with a polyhistidine tract polymorphism in the ZIC2 gene." in: American journal of medical genetics, Vol. 108, Issue 2, pp. 128-31, (2002) (PubMed).

Synonyms and alternative names related to ZIC2

Zic family member 2 (ZIC2), zinc finger protein of the cerebellum 2 (Zic2), Zic family member 2 (Zic2), zic family member 2 (odd-paired homolog, Drosophila), a (zic2a), Zic family member 2 L homeolog (zic2.L), zic family member 2 (odd-paired homolog, Drosophila) b (zic2b), cb851, fb26a03, hm:zeh0655, HPE5, hpe5, id:ibd5017, Ku, wu:fb26a03, zic2, zic2.1, zic2.2, zic2l

Protein level used designations for ZIC2

  • Zic family member 2 (odd-paired homolog, Drosophila)
  • Zinc finger protein of the cerebellum 2
  • zinc finger protein ZIC 2
  • GENA 29
  • kumba
  • odd-paired homolog
  • zinc finger protein of the cerebellum 2
  • zinc finger cerebellum 2
  • cerebellum zinc finger protein 2
  • Zic family member 2 (odd-paired homolog)
  • Zinc finger protein ZIC 2
  • xZic2
  • xlZic2
  • zinc finger DNA-binding protein fZic
  • zinc finger protein ZIC 2-A
  • zinc finger protein of the cerebellum 2-A
  • zic family member 2b
  • zinc finger cerebellum 2, like
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