ZAK 抗体
(Mitogen-Activated Protein Kinase Kinase Kinase MLT (ZAK))
This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
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Latest Publications for our ZAK 抗体
: "NEMO regulates a cell death switch in TNF signaling by inhibiting recruitment of RIPK3 to the cell death-inducing complex II." in: Cell death & disease, Vol. 7, Issue 8, pp. e2346, (2017) (PubMed).: "A Requirement for ZAK Kinase Activity in Canonical TGF-β Signaling." in: Translational oncology, Vol. 9, Issue 6, pp. 473-481, (2016) (PubMed).
: "Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer. ..." in: Nature communications, Vol. 5, pp. 3830, (2014) (PubMed).
: "A-kinase anchoring protein Lbc coordinates a p38 activating signaling complex controlling compensatory cardiac hypertrophy." in: Molecular and cellular biology, Vol. 33, Issue 15, pp. 2903-17, (2013) (PubMed).
: "A-kinase anchoring protein (AKAP)-Lbc anchors a PKN-based signaling complex involved in ?1-adrenergic receptor-induced p38 activation." in: The Journal of biological chemistry, Vol. 286, Issue 10, pp. 7925-37, (2011) (PubMed).
: "Phosphoinositide 3-kinase signalling pathways." in: Journal of cell science, Vol. 114, Issue Pt 8, pp. 1439-45, (2001) (PubMed).
: "Oncogenic kinase signalling." in: Nature, Vol. 411, Issue 6835, pp. 355-65, (2001) (PubMed).
: "The RET proto-oncogene in human cancers." in: Oncogene, Vol. 19, Issue 49, pp. 5590-7, (2000) (PubMed).
Aliases for ZAK 抗体
mitogen-activated protein kinase kinase kinase 20 (Map3k20) 抗体mitogen-activated protein kinase kinase kinase 20 (MAP3K20) 抗体
AV006891 抗体
AZK 抗体
B230120H23Rik 抗体
MLK7 抗体
mlklak 抗体
MLT 抗体
MLTK 抗体
MLTKalpha 抗体
MLTKbeta 抗体
MRK 抗体
pk 抗体
RGD1561394 抗体
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