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YARS 产品

(Tyrosyl-tRNA Synthetase (Yars))

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Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine. [provided by RefSeq, Jul 2008].

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Featured YARS Categories

YARS 抗体

High quality antibodies with extensive validation data.

YARS 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

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Latest Publications for our YARS Products

Zhang, Zhai, Tang, Cheng, Li, Wang, Zhu: "Quantitative proteome-based systematic identification of SIRT7 substrates." in: Proteomics, Vol. 17, Issue 13-14, (2017) (PubMed).

Wei, Xu, Liu, Lo, Ye, Lau, Wang, Zhou, Nangle, Yang, Zhang, Schimmel: "Alternative splicing creates two new architectures for human tyrosyl-tRNA synthetase." in: Nucleic acids research, Vol. 44, Issue 3, pp. 1247-55, (2016) (PubMed).

Niehues, Bussmann, Steffes, Erdmann, Köhrer, Sun, Wagner, Schäfer, Wang, Koerdt, Stum, RajBhandary, Thomas, Aberle, Burgess, Yang, Dieterich, Storkebaum: "Impaired protein translation in Drosophila models for Charcot-Marie-Tooth neuropathy caused by mutant tRNA synthetases." in: Nature communications, Vol. 6, pp. 7520, (2015) (PubMed).

Storkebaum, Leitão-Gonçalves, Godenschwege, Nangle, Mejia, Bosmans, Ooms, Jacobs, Van Dijck, Yang, Schimmel, Norga, Timmerman, Callaerts, Jordanova: "Dominant mutations in the tyrosyl-tRNA synthetase gene recapitulate in Drosophila features of human Charcot-Marie-Tooth neuropathy." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 28, pp. 11782-7, (2009) (PubMed).

Yang, Kapoor, Otero, Slike, Tsuruta, Frausto, Bates, Ewalt, Cheresh, Schimmel: "Gain-of-function mutational activation of human tRNA synthetase procytokine." in: Chemistry & biology, Vol. 14, Issue 12, pp. 1323-33, (2007) (PubMed).

Jordanova, Irobi, Thomas, Van Dijck, Meerschaert, Dewil, Dierick, Jacobs, De Vriendt, Guergueltcheva, Rao, Tournev, Gondim, DHooghe, Van Gerwen, Callaerts, Van Den Bosch, Timmermans, Robberecht et al.: "Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy. ..." in: Nature genetics, Vol. 38, Issue 2, pp. 197-202, (2006) (PubMed).

Bonnefond, Fender, Rudinger-Thirion, Giegé, Florentz, Sissler: "Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS." in: Biochemistry, Vol. 44, Issue 12, pp. 4805-16, (2005) (PubMed).

Synonyms and alternative names related to YARS

tyrosyl-tRNA synthetase (YARS), tyrosyl-tRNA synthetase (Yars), tyrosyl-tRNA synthetase (yars), tyrosyl-tRNA synthetase L homeolog (yars.L), tyrosyl-tRNA synthetase, putative (MAL8P1.125), tyrosine--tRNA ligase (MEFER_RS04475), Tyrosyl-tRNA synthetase (TyrRS), tyrosine--tRNA ligase, cytoplasmic (LOC413909), tyrosine--tRNA ligase, cytoplasmic (LOC100163888), tyrosyl-tRNA synthetase (LOC100282315), AL024047, anon-EST:Posey261, AU018965, cb204, CG4561, CMTDIC, cmtdic, Dmel\\CG4561, dYARS, GB10789, TYRRS, tyrrs, TyrRS, wu:fk52b08, YARS, YRS, yrs, YTS, yts

Protein level used designations for YARS

  • tyrosine tRNA ligase 1, cytoplasmic
  • tyrosine--tRNA ligase, cytoplasmic
  • tyrosyl--tRNA ligase
  • tyrosyl-tRNA synthetase, cytoplasmic
  • Tyrosyl-tRNA synthetase, cytoplasmic
  • tyrRS
  • tyrosyl-tRNA synthetase
  • Aats-tyr-PA
  • CG4561-PA
  • ACYPI004940
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