WWP1 蛋白
(WW Domain Containing E3 Ubiquitin Protein Ligase 1 (WWP1))
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1\; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF.
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3 results
custom-made
WWP1
宿主: 人
宿主: HEK-293 Cells
Recombinant
> 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
WWP1
宿主: 人
宿主: 大肠杆菌（E. Coli）
Recombinant
Greater than 90 % by SDS-PAGE gel analyses
ELISA, WB
1 image
custom-made
WWP1
宿主: 人
宿主: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
ELISA, WB, SDS
Aliases for WWP1 蛋白
WW domain containing E3 ubiquitin protein ligase 1 (WWP1) 蛋白WW domain containing E3 ubiquitin protein ligase 1 (Wwp1) 蛋白
WW domain containing E3 ubiquitin protein ligase 1 (wwp1) 蛋白
8030445B08Rik 蛋白
AIP5 蛋白
aip5 蛋白
hSDRP1 蛋白
hsdrp1 蛋白
SDRP1 蛋白
Tiul1 蛋白
tiul1 蛋白
WWP1 蛋白
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