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抗Human SFRP1 抗体:
抗Mouse (Murine) SFRP1 抗体:
抗Rat (Rattus) SFRP1 抗体:
Human Polyclonal SFRP1 Primary Antibody for ELISA, IHC - ABIN1585200
Kim, Jung, Baek, Lee, Choi, Lee, Chung, Lee: Regional biases in mutation screening due to intratumoural heterogeneity of prostate cancer. in The Journal of pathology 2014
Human Polyclonal SFRP1 Primary Antibody for IF (p), IHC (p) - ABIN674694
Wang, Xie, Xie, Wan, Ma, Qi, Yang: MiR-27a regulates Wnt/beta-catenin signaling through targeting SFRP1 in glioma. in Neuroreport 2015
Cow (Bovine) Polyclonal SFRP1 Primary Antibody for WB - ABIN2792235
Caldwell, Jones, Taniere, Warrack, Soon, Matthews, Morton: The Wnt antagonist sFRP1 is downregulated in premalignant large bowel adenomas. in British journal of cancer 2006
Show all 2 Pubmed References
Human Polyclonal SFRP1 Primary Antibody for ELISA, IHC - ABIN4353134
Gumz, Zou, Kreinest, Childs, Belmonte, LeGrand, Wu, Luxon, Sinha, Parker, Sun, Ahlquist, Wood, Copland: Secreted frizzled-related protein 1 loss contributes to tumor phenotype of clear cell renal cell carcinoma. in Clinical cancer research : an official journal of the American Association for Cancer Research 2007
Methylation of SFRP1, SFRP2, SDC2, and PRIMA1 promoter sequences was observed in 85.1%, 72.3%, 89.4%, and 80.9% of plasma samples from patients with Colorectal cancer and 89.2%, 83.8%, 81.1% and 70.3% from adenoma patients, respectively.
preliminary data show loss of SFRP1 protein expression caused by the SFRP1 promoter hypermethylation in a subset of high-grade serous ovarian carcinomas
Loss of SFRP1 likely contributes to tumor progression by altering the expression of a critical transcription factor in both the epithelium and the immune system.
Authors found that downregulation of HP1alpha (显示 CBX5 抗体) can decrease H3K9me3 enrichment and DNA methylation (显示 HELLS 抗体) rate of secreted frizzled-related protein 1 (SFRP1) promoter, resulting in restoring the expression of SFRP1.
KL and SFRP1 methylation were more predominant in nasopharyngeal tumors.
Results indicate that SFRP1 rs7832767 C > T, CTNNB1 (显示 CTNNB1 抗体) rs2293303 C > T, and WISP1 (显示 WISP1 抗体) rs16893344 C > T were all strongly correlated with myocardial infarction (MI) susceptibility.
miR (显示 MLXIP 抗体)-1254 promotes lung cancer cell proliferation by targeting the expression of SFRP1.
The expression of Dicer (显示 DICER1 抗体) negatively correlated with that of SFRP1 and it appeared to promote CCA (显示 FBN2 抗体) cell proliferation.
H2O2-induced SFRP1 gene demethylation contributes to H2O2-induced apoptosis in human U251 glioma cells.
Data suggest that microRNA miR (显示 MLXIP 抗体)-27a may activate the Wnt (显示 WNT2 抗体)/beta-catenin (显示 CTNNB1 抗体) signaling pathway by negatively regulating SFRP1 to promote the proliferation, migration and invasion of breast cancer (BC) cells.
OVOL1 (显示 OVOL1 抗体)-regulated Fst (显示 FST 抗体) and SFRP1 affect hair inductive potency of neonatal dermal cells.
Down stream actions of estrogen-mediated signaling, including cellular proliferation and progesterone receptor (显示 PGR 抗体) transcription, are elevated in estradiol treated explant cultures derived from Sfrp1(-/-) mice.
Study suggests that the induction of the WNT (显示 WNT2 抗体) pathway is a potentially crucial pathway in the development of cardiomyopathy with aging with sFRP-1 being a critical factor in maintaining normal cardiovascular structure and function during this process.
the expression of Sfrp1 is a critical factor required for maintaining appropriate cellular signaling in response to the onset of obesity
findings suggest that SFRP1 expression in the adult maintains progenitor cells within their undifferentiated state and suggests that manipulation of this pathway is a potential target to augment the lung repair process during disease
Sfrp1 is required for inhibition of renal damage through the non-canonical Wnt (显示 WNT2 抗体)/PCP (显示 BMP1 抗体) pathway in a mouse model of obstructive nephropathy
SFRP1 deficiency in mice results in the development of diet-induced obesity aggravated by inflammation and breast cancer.
Sfrp1(-/-) mice have less DNA fragmentation, whilst caspase-3 (显示 CASP3 抗体) expression is decreased, and that p53 (显示 TP53 抗体) expression is generally diminished.
secreted FRP1 either inhibits or enhances signaling in the Wnt3a (显示 WNT3A 抗体)/beta-catenin (显示 CTNNB1 抗体) pathway
Results show the expression level of SFRP1 significantly higher in the embryonic skeletal muscle and diminishes after, whereas miR-206/1 show the inverse. Also, SFRP1 gene is regulated by miR-1/206 and potentially affects skeletal muscle development.
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling\; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina.
secreted frizzled-related protein 1
, Secreted frizzled-related protein 1
, secreted apoptosis-related protein 2
, secreted frizzled related protein 1
, frizzled in aorta protein
, frzA protein
, secreted frizzled-related sequence protein 1