This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. The encoded protein interacts with serine/threonine kinase 11, and is implicated in cell growth arrest. [provided by RefSeq, Aug 2008].
Chiba, Inoue, Mizuno, Komatsu, Fujita, Kubota, Luisa Tagliaro, Park, Trindade, Hayashida, Hayashi, Yamaza, Higami, Shimokawa: "Identification and characterization of an insulin receptor substrate 4-interacting protein in rat brain: implications for longevity." in: Neurobiology of aging, Vol. 30, Issue 3, pp. 474-82, (2009) (PubMed).