WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI1, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids (Proikas-Cezanne et al., 2004 [PubMed 15602573]).[supplied by OMIM, Mar 2008].
Felzen, Hiebel, Koziollek-Drechsler, Reißig, Wolfrum, Kögel, Brandts, Behl, Morawe: "Estrogen receptor α regulates non-canonical autophagy that provides stress resistance to neuroblastoma and breast cancer cells and involves BAG3 function." in: Cell death & disease, Vol. 6, pp. e1812, (2015) (PubMed).
Aliases for WD Repeat Domain, phosphoinositide Interacting 1 抗体