The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. Mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be a yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 18\; the gene for the other resides on chromosome 16. [provided by RefSeq, Jul 2008].
Xu, Zhai, Ge, Liu, Tao: "Vacuolar Protein Sorting 4B (VPS4B) Regulates Apoptosis of Chondrocytes via p38 Mitogen-Activated Protein Kinases (MAPK) in Osteoarthritis." in: Inflammation, Vol. 40, Issue 6, pp. 1924-1932, (2018) (PubMed).
Du, Kazim, Dawes, Brown, Yang: "The AAA ATPase VPS4/SKD1 regulates endosomal cholesterol trafficking independently of ESCRT-III." in: Traffic (Copenhagen, Denmark), Vol. 14, Issue 1, pp. 107-19, (2013) (PubMed).
Lin, Li, Chen, Sun, Cooper, Chen, Zhang, Chung, Li, Cheng, Yang, Deng, Liu, Yen, Johnson, Shih, Yang, Ann: "Identification of an AAA ATPase VPS4B-dependent pathway that modulates epidermal growth factor receptor abundance and signaling during hypoxia." in: Molecular and cellular biology, Vol. 32, Issue 6, pp. 1124-38, (2012) (PubMed).
Ariumi, Kuroki, Maki, Ikeda, Dansako, Wakita, Kato: "The ESCRT system is required for hepatitis C virus production." in: PLoS ONE, Vol. 6, Issue 1, pp. e14517, (2011) (PubMed).
Aliases for VPS4B 抗体
vacuolar protein sorting 4 homolog B (Vps4b) 抗体 vacuolar protein sorting 4 homolog B S homeolog (vps4b.S) 抗体 vacuolar protein sorting 4b homolog B (S. cerevisiae) (vps4b) 抗体 vacuolar protein sorting 4 homolog B (VPS4B) 抗体 vacuolar protein sorting 4 homolog B (vps4b) 抗体 vacuolar protein sorting 4 homolog B (S. cerevisiae) (VPS4B) 抗体 vacuolar protein sorting 4B (Vps4b) 抗体 8030489C12Rik 抗体 SKD1 抗体 Skd1 抗体 SKD1B 抗体 VPS4-2 抗体 vps4a 抗体 zgc:63682 抗体