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VHLL 蛋白

(Von Hippel-Lindau Tumor Suppressor-Like (VHLL))

Von Hippel-Lindau (VHL) tumor suppressor protein is a component of an E3 ubiquitin ligase complex that selectively ubiquitinates the alpha subunit of the hypoxia-inducible factor (HIF) transcription factor for proteasome-mediated degradation. Inactivation of VHL causes VHL disease and sporadic kidney cancer. This gene encodes a VHL homolog that lacks one of two key domains necessary for VHL function. This gene may contribute to the regulation of oxygen homeostasis and neovascularization during placenta development. This gene is intronless, and can also be interpreted as a retrotransposed pseudogene of the VHL locus located on chromosome 3. However, the protein is represented in this RefSeq due to evidence in PMID:14757845 that strongly suggests it is translated. The same publication also indicates that this protein binds HIF alpha but fails to recruit the E3 ubiquitin ligase complex, and it therefore functions as a dominant-negative VHL protein and a protector of HIF alpha. [provided by RefSeq, Jan 2010].

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VHLL Protein (AA 1-139) (His tag) (ABIN7545031)

custom-made VHLL 宿主: 人宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

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Popular VHLL 蛋白

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Reactivity

Source

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Cat. No.

Quantity

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VHLL Protein (AA 1-139) (His tag)

Reactivity Human

Source HEK-293 Cells

Validations

Cat. No. ABIN7545031

Quantity 1 mg

Datasheet Datasheet

Aliases for VHLL 蛋白

VHL like (VHLL) 蛋白
VHLP 蛋白
VLP 蛋白

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