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VHLL 蛋白

(Von Hippel-Lindau Tumor Suppressor-Like (VHLL))
Von Hippel-Lindau (VHL) tumor suppressor protein is a component of an E3 ubiquitin ligase complex that selectively ubiquitinates the alpha subunit of the hypoxia-inducible factor (HIF) transcription factor for proteasome-mediated degradation. Inactivation of VHL causes VHL disease and sporadic kidney cancer. This gene encodes a VHL homolog that lacks one of two key domains necessary for VHL function. This gene may contribute to the regulation of oxygen homeostasis and neovascularization during placenta development. This gene is intronless, and can also be interpreted as a retrotransposed pseudogene of the VHL locus located on chromosome 3. However, the protein is represented in this RefSeq due to evidence in PMID:14757845 that strongly suggests it is translated. The same publication also indicates that this protein binds HIF alpha but fails to recruit the E3 ubiquitin ligase complex, and it therefore functions as a dominant-negative VHL protein and a protector of HIF alpha. [provided by RefSeq, Jan 2010].

4 results :

custom-made VHLL 宿主: 人 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
产品编号 ABIN7545031
 
custom-made VHLL 宿主: 人 宿主: Cell-free protein synthesis (CFPS) Recombinant approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). ELISA, SDS, WB
产品编号 ABIN3075289
 
VHLL 宿主: 人 Recombinant
产品编号 ABIN1068513
 
VHLL 宿主: 人 Recombinant > 95.0 % as determined by SDS-PAGE.
产品编号 ABIN620853
 
  • 类型 Protein
    • Protein
  • 应用范围
    • ELISA
    • SDS-PAGE (SDS)
    • Western Blotting (WB)
  • 适用
    • Human
  • 图像
  • Carrier free only
  • 抗体来源
    • Cell-free protein synthesis (CFPS)
    • HEK-293 Cells
  • 抗原表位
    • AA 1-139
    • AA 1-154
  • 标记
    • His tag
    • Strep Tag
    • 非结合性
  • 蛋白类型
    • Recombinant
  • Format
    • Liquid
  • Grade
    • custom-made
  • Supplier
    • antibodies-online
    • ITSI-Biosciences
    • RayBiotech

Aliases for VHLL 蛋白

VHL like (VHLL) 蛋白
VHLP 蛋白
VLP 蛋白
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