This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. The protein specifically deubiquitinates a protein in the Fanconi anemia (FA) DNA repair pathway. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008].
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Zhiqiang, Qinghui, Yongqiang, Jian, Xin, Haiying, Yuepeng: "USP1 regulates AKT phosphorylation by modulating the stability of PHLPP1 in lung cancer cells." in: Journal of cancer research and clinical oncology, Vol. 138, Issue 7, pp. 1231-8, (2012) (PubMed).
Murai, Yang, Dejsuphong, Hirota, Takeda, DAndrea: "The USP1/UAF1 complex promotes double-strand break repair through homologous recombination." in: Molecular and cellular biology, Vol. 31, Issue 12, pp. 2462-9, (2011) (PubMed).
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Aliases for USP1 抗体
ubiquitin specific peptidase 1 (USP1) 抗体 ubiquitin specific peptidase 1 S homeolog (usp1.S) 抗体 ubiquitin specific peptidase 1 (Usp1) 抗体 UBP 抗体 usp1-a 抗体