This gene encodes member of the prefoldin family of molecular chaperones. The encoded protein functions as a scaffolding protein and plays roles in ubiquitination and transcription, in part though interactions with the RNA polymerase II subunit RPB5. This gene may play a role in multiple malignancies including ovarian cancer and hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 22. [provided by RefSeq, Nov 2011].
Mita, Savas, Djouder, Yates, Ha, Ruoff, Schafler, Nwachukwu, Tanese, Cowan, Zavadil, Garabedian, Logan: "Regulation of androgen receptor-mediated transcription by RPB5 binding protein URI/RMP." in: Molecular and cellular biology, Vol. 31, Issue 17, pp. 3639-52, (2011) (PubMed).
Delgermaa, Hayashi, Dorjsuren, Nomura, Thuy, Murakami: "Subcellular localization of RPB5-mediating protein and its putative functional partner." in: Molecular and cellular biology, Vol. 24, Issue 19, pp. 8556-66, (2004) (PubMed).
Gstaiger, Luke, Hess, Oakeley, Wirbelauer, Blondel, Vigneron, Peter, Krek: "Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI." in: Science (New York, N.Y.), Vol. 302, Issue 5648, pp. 1208-12, (2003) (PubMed).
Aliases for URI1 抗体
URI1 prefoldin-like chaperone L homeolog (uri1.L) 抗体 URI1, prefoldin like chaperone (URI1) 抗体 c19orf2 抗体 C19orf2 抗体 NNX3 抗体 PPP1R19 抗体 RMP 抗体 URI 抗体