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UPF3A 产品

(UPF3 Regulator of Nonsense Transcripts Homolog A (UPF3A))

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This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome 13. Two splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

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Featured UPF3A Categories

UPF3A 抗体

High quality antibodies with extensive validation data.

UPF3A 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended UPF3A 抗体

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Reactivity
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Datasheet
Reactivity Human
Application WB, ELISA, IHC (p)
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  • (4)
Cat. No. ABIN528787
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IF
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  • (4)
Cat. No. ABIN7271227
Quantity 100 μL
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Reactivity Human
Application WB, IF
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Cat. No. ABIN528786
Quantity 50 μg
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Recommended UPF3A ELISA试剂盒

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Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
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Cat. No. ABIN6208301
Quantity 96 tests
Datasheet Datasheet

Recommended UPF3A 蛋白

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Reactivity
Source
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Source Wheat germ
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Cat. No. ABIN1324688
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
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  • (1)
Cat. No. ABIN1324686
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
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  • (1)
Cat. No. ABIN3094956
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our UPF3A Products

Tarpey, Raymond, Nguyen, Rodriguez, Hackett, Vandeleur, Smith, Shoubridge, Edkins, Stevens, OMeara, Tofts, Barthorpe, Buck, Cole, Halliday, Hills, Jones, Mironenko, Perry, Varian, West, Widaa, Teague et al.: "Mutations in UPF3B, a member of the nonsense-mediated mRNA decay complex, cause syndromic and nonsyndromic mental retardation. ..." in: Nature genetics, Vol. 39, Issue 9, pp. 1127-33, (2007) (PubMed).

Synonyms and alternative names related to UPF3A

UPF3 regulator of nonsense transcripts homolog A (yeast) (Upf3a), UPF3A, regulator of nonsense mediated mRNA decay (Upf3a), UPF3 regulator of nonsense transcripts homolog A (yeast) (UPF3A), UPF3A, regulator of nonsense mediated mRNA decay (UPF3A), UPF3A, regulator of nonsense mediated mRNA decay (upf3a), 2600001C03Rik, 4930546M19Rik, HUPF3A, RENT3A, si:dkey-21o13.6, UPF3, UPF3A

Protein level used designations for UPF3A

  • UPF3 regulator of nonsense transcripts homolog A
  • regulator of nonsense transcripts 3A
  • UPF3 regulator of nonsense transcripts homolog A (yeast)
  • regulator of nonsense transcripts 3A-like
  • hUpf3
  • nonsense mRNA reducing factor 3A
  • up-frameshift suppressor 3 homolog A
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