(Ubiquitin-Like with PHD and Ring Finger Domains 2, E3 Ubiquitin Protein Ligase (UHRF2))
This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding. [provided by RefSeq, Feb 2012].
Liu, Zhu, Zhou, Zhang, Xu, Li: "[Analysis of diagnosis and misdiagnosis of pulmonary thromboembolism in emergency]." in: Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue, Vol. 16, Issue 8, pp. 464-7, (2004) (PubMed).
Aliases for UHRF2 抗体
ubiquitin like with PHD and ring finger domains 2 (UHRF2) 抗体 ubiquitin-like, containing PHD and RING finger domains 2 (Uhrf2) 抗体 ubiquitin like with PHD and ring finger domains 2 (Uhrf2) 抗体 ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase L homeolog (uhrf2.L) 抗体 2310065A22Rik 抗体 AI426270 抗体 AW214556 抗体 D130071B19Rik 抗体 NIRF 抗体 Nirf 抗体 RNF107 抗体 URF2 抗体